Gene/Proteome Database (LMPD)
LMPD ID
LMP006247
Gene ID
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class M
Gene Symbol
Synonyms
GPI-MT-I
Alternate Names
GPI mannosyltransferase 1; GPI mannosyltransferase I; PIG-M mannosyltransferase; DPM:GlcN-(acyl-)PI mannosyltransferase; dol-P-Man dependent GPI mannosyltransferase; phosphatidylinositol-glycan biosynthesis class M protein
Chromosome
1
Map Location
1q23.2
EC Number
2.4.1.-
Summary
This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| GPI mannosyltransferase 1 | |
|---|---|
| Refseq ID | NP_660150 |
| Protein GI | 21553315 |
| UniProt ID | Q9H3S5 |
| mRNA ID | NM_145167 |
| Length | 423 |
| RefSeq Status | REVIEWED |
| MGSTKHWGEWLLNLKVAPAGVFGVAFLARVALVFYGVFQDRTLHVRYTDIDYQVFTDAARFVTEGRSPYLRATYRYTPLLGWLLTPNIYLSELFGKFLFISCDLLTAFLLYRLLLLKGLGRRQACGYCVFWLLNPLPMAVSSRGNADSIVASLVLMVLYLIKKRLVACAAVFYGFAVHMKIYPVTYILPITLHLLPDRDNDKSLRQFRYTFQACLYELLKRLCNRAVLLFVAVAGLTFFALSFGFYYEYGWEFLEHTYFYHLTRRDIRHNFSPYFYMLYLTAESKWSFSLGIAAFLPQLILLSAVSFAYYRDLVFCCFLHTSIFVTFNKVCTSQYFLWYLCLLPLVMPLVRMPWKRAVVLLMLWFIGQAMWLAPAYVLEFQGKNTFLFIWLAGLFFLLINCSILIQIISHYKEEPLTERIKYD | |
Gene Information
Entrez Gene ID
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class M
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005789 | TAS:Reactome | C | endoplasmic reticulum membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0000030 | IEA:Ensembl | F | mannosyltransferase activity |
| GO:0006501 | TAS:Reactome | P | C-terminal protein lipidation |
| GO:0044267 | TAS:Reactome | P | cellular protein metabolic process |
| GO:0043687 | TAS:Reactome | P | post-translational protein modification |
| GO:0016254 | TAS:Reactome | P | preassembly of GPI anchor in ER membrane |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa00563 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |
| hsa01100 | Metabolic pathways |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_952 | Synthesis of glycosylphosphatidylinositol (GPI) |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR007704 | Mannosyltransferase, DXD |
UniProt Annotations
Entry Information
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class M
Protein Entry
PIGM_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Disease | Glycosylphosphatidylinositol deficiency (GPID) [MIM |
| Function | Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. |
| Pathway | Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis. |
| Similarity | Belongs to the PIGM family. |
| Subcellular Location | Endoplasmic reticulum membrane ; Multi-pass membrane protein . |
Identical and Related Proteins
Unique RefSeq proteins for LMP006247 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 21553315 | RefSeq | NP_660150 | 423 | GPI mannosyltransferase 1 |
Identical Sequences to LMP006247 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:21553315 | EMBL | CAH91233.1 | 423 | hypothetical protein [Pongo abelii] |
| GI:21553315 | GenBank | EAW52751.1 | 423 | phosphatidylinositol glycan, class M, isoform CRA_a [Homo sapiens] |
| GI:21553315 | GenBank | AIC52784.1 | 423 | PIGM, partial [synthetic construct] |
| GI:21553315 | RefSeq | NP_001125728.1 | 423 | GPI mannosyltransferase 1 [Pongo abelii] |
| GI:21553315 | SwissProt | Q9H3S5.1 | 423 | RecName: Full=GPI mannosyltransferase 1; AltName: Full=GPI mannosyltransferase I; Short=GPI-MT-I; AltName: Full=Phosphatidylinositol-glycan biosynthesis class M protein; Short=PIG-M [Homo sapiens] |
| GI:21553315 | SwissProt | Q5RAH7.1 | 423 | RecName: Full=GPI mannosyltransferase 1; AltName: Full=GPI mannosyltransferase I; Short=GPI-MT-I; AltName: Full=Phosphatidylinositol-glycan biosynthesis class M protein; Short=PIG-M [Pongo abelii] |
Related Sequences to LMP006247 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:21553315 | DBBJ | BAK63139.1 | 423 | GPI mannosyltransferase 1 [Pan troglodytes] |
| GI:21553315 | GenBank | JAA07499.1 | 423 | phosphatidylinositol glycan anchor biosynthesis, class M [Pan troglodytes] |
| GI:21553315 | GenBank | JAA14821.1 | 423 | phosphatidylinositol glycan anchor biosynthesis, class M [Pan troglodytes] |
| GI:21553315 | GenBank | JAA22685.1 | 423 | phosphatidylinositol glycan anchor biosynthesis, class M [Pan troglodytes] |
| GI:21553315 | GenBank | JAA33400.1 | 423 | phosphatidylinositol glycan anchor biosynthesis, class M [Pan troglodytes] |
| GI:21553315 | RefSeq | NP_001233402.1 | 423 | GPI mannosyltransferase 1 [Pan troglodytes] |