Gene/Proteome Database (LMPD)

LMPD ID
LMP006274
Gene ID
Species
Homo sapiens (Human)
Gene Name
protein arginine methyltransferase 5
Gene Symbol
Synonyms
HRMT1L5; IBP72; JBP1; SKB1; SKB1Hs
Chromosome
14
Map Location
14q11.2
EC Number
2.1.1.-

Proteins

protein arginine N-methyltransferase 5 isoform a
Refseq ID NP_006100
Protein GI 20070220
UniProt ID O14744
mRNA ID NM_006109
Length 637
RefSeq Status VALIDATED
MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL
protein arginine N-methyltransferase 5 isoform b
Refseq ID NP_001034708
Protein GI 88900507
UniProt ID O14744
mRNA ID NM_001039619
Length 620
RefSeq Status VALIDATED
MRGPNSGTEKGRLVIPEKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL
protein arginine N-methyltransferase 5 isoform c
Refseq ID NP_001269882
Protein GI 545479147
UniProt ID O14744
mRNA ID NM_001282953
Length 576
RefSeq Status VALIDATED
MRGPNSGTEKGRLVIPEKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL
protein arginine N-methyltransferase 5 isoform d
Refseq ID NP_001269883
Protein GI 545478838
UniProt ID B4DV00
mRNA ID NM_001282954
Length 531
RefSeq Status VALIDATED
MLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL
protein arginine N-methyltransferase 5 isoform e
Refseq ID NP_001269884
Protein GI 545477926
UniProt ID O14744
mRNA ID NM_001282955
Length 593
RefSeq Status VALIDATED
MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL
protein arginine N-methyltransferase 5 isoform f
Refseq ID NP_001269885
Protein GI 545478755
UniProt ID O14744
mRNA ID NM_001282956
Length 466
RefSeq Status VALIDATED
MRGPNSGTEKGRLVIPEKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEALEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL

Gene Information

Entrez Gene ID
Gene Name
protein arginine methyltransferase 5
Gene Symbol
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:HPA C cytoplasm
GO:0005829 IDA:UniProtKB C cytosol
GO:0034709 IDA:UniProtKB C methylosome
GO:0005634 NAS:UniProtKB C nucleus
GO:0003682 IEA:Ensembl F chromatin binding
GO:0001046 ISS:UniProtKB F core promoter sequence-specific DNA binding
GO:0008469 IBA:RefGenome F histone-arginine N-methyltransferase activity
GO:0008168 IDA:MGI F methyltransferase activity
GO:0035243 IMP:UniProtKB F protein-arginine omega-N symmetric methyltransferase activity
GO:0043021 IPI:UniProtKB F ribonucleoprotein complex binding
GO:0003714 ISS:UniProtKB F transcription corepressor activity
GO:0016070 TAS:Reactome P RNA metabolic process
GO:0008283 TAS:ProtInc P cell proliferation
GO:0032922 ISS:UniProtKB P circadian regulation of gene expression
GO:0042118 IMP:UniProtKB P endothelial cell activation
GO:0010467 TAS:Reactome P gene expression
GO:0043985 ISS:UniProtKB P histone H4-R3 methylation
GO:0034660 TAS:Reactome P ncRNA metabolic process
GO:0000122 IEA:Ensembl P negative regulation of transcription from RNA polymerase II promoter
GO:0035246 IDA:MGI P peptidyl-arginine N-methylation
GO:0018216 IMP:UniProtKB P peptidyl-arginine methylation
GO:0019918 IMP:GOC P peptidyl-arginine methylation, to symmetrical-dimethyl arginine
GO:0007088 TAS:ProtInc P regulation of mitosis
GO:0006355 IBA:RefGenome P regulation of transcription, DNA-templated
GO:0000387 IMP:UniProtKB P spliceosomal snRNP assembly
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

KEGG Pathway Links

KEGG Pathway ID Description
hsa03013 RNA transport
ko03013 RNA transport

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_228108 RMTs methylate histone arginines
REACT_11066 snRNP Assembly

Domain Information

InterPro Annotations

Accession Description
IPR025799 Protein arginine N-methyltransferase
IPR007857 Protein arginine N-methyltransferase PRMT5
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase

UniProt Annotations

Entry Information

Gene Name
protein arginine methyltransferase 5
Protein Entry
ANM5_HUMAN
UniProt ID
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seems to exist. According to EST sequences.; Name=1; IsoId=O14744-1; Sequence=Displayed; Name=2; IsoId=O14744-2; Sequence=VSP_043382; Note=No experimental confirmation available.; Name=4; IsoId=O14744-4; Sequence=VSP_043382, VSP_054768; Note=No experimental confirmation available.; Name=5; IsoId=O14744-5; Sequence=VSP_054685; Note=No experimental confirmation available.; Name=3; IsoId=O14744-3; Sequence=VSP_043382, VSP_054685; Note=No experimental confirmation available.;
Catalytic Activity S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone].
Enzyme Regulation Activity is increased by EGF, HGF, FGF1 or FGF2 treatments, and slightly decreased by NGF treatment.
Function Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9. Methylates and regulates SRGAP2 which is involved in cell migration and differentiation. Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter. {ECO
Interaction Q8N8U2:CDYL2; NbExp=2; IntAct=EBI-351098, EBI-8467076; P54105:CLNS1A; NbExp=3; IntAct=EBI-351098, EBI-724693; Q9NQ92:COPRS; NbExp=6; IntAct=EBI-351098, EBI-1642558; Q01094:E2F1; NbExp=8; IntAct=EBI-351098, EBI-448924; Q8TE85:GRHL3; NbExp=2; IntAct=EBI-351098, EBI-8469396; Q9BX10:GTPBP2; NbExp=2; IntAct=EBI-351098, EBI-6115579; P62805:HIST2H4B; NbExp=3; IntAct=EBI-351098, EBI-302023; Q8WVJ2:NUDCD2; NbExp=2; IntAct=EBI-351098, EBI-1052153; Q86U06:RBM23; NbExp=3; IntAct=EBI-351098, EBI-780319; O75044:SRGAP2; NbExp=4; IntAct=EBI-351098, EBI-1051034; Q96RU7:TRIB3; NbExp=2; IntAct=EBI-351098, EBI-492476; Q9BQA1:WDR77; NbExp=6; IntAct=EBI-351098, EBI-1237307; P63104:YWHAZ; NbExp=2; IntAct=EBI-351098, EBI-347088;
Sequence Caution Sequence=BC005820; Type=Frameshift; Positions=370; Evidence= ;
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family.
Similarity Contains 1 SAM-dependent MTase PRMT-type domain.
Subcellular Location Cytoplasm. Nucleus.
Subunit Forms, at least, homodimers and homotetramers. Interacts with PRDM1 (By similarity). Component of the methylosome, a 20S complex containing at least CLNS1A/pICln, PRMT5/SKB1 and WDR77/MEP50. Interacts with EGFR; methylates EGFR and stimulates EGFR-mediated ERK activation. Interacts with HOXA9. Interacts with SRGAP2. Found in a complex with COPRS, RUNX1 AND CBFB. Interacts with CHTOP; the interaction symmetrically methylates CHTOP, but seems to require the presence of PRMT1 (By similarity). Interacts with EPB41L3; this modulates methylation of target proteins. Component of a high molecular weight E2F-pocket protein complex, CERC (cyclin E1 repressor complex). Associates with SWI/SNF remodeling complexes containing SMARCA2 and SMARCA4. Interacts with JAK2, SSTR1, SUPT5H, BRAF and with active RAF1. Interacts with LSM11, PRMT7 and SNRPD3. Interacts with COPRS; promoting its recruitment on histone H4. Interacts with CLNS1A/pICln. Identified in a complex with CLNS1A/pICln and Sm proteins. Interacts with RPS10. Interacts with WDR77. Interacts with IWS1. Interacts with CRY1. {ECO
Tissue Specificity Ubiquitous.

Identical and Related Proteins

Unique RefSeq proteins for LMP006274 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
20070220 RefSeq NP_006100 637 protein arginine N-methyltransferase 5 isoform a
88900507 RefSeq NP_001034708 620 protein arginine N-methyltransferase 5 isoform b
545479147 RefSeq NP_001269882 576 protein arginine N-methyltransferase 5 isoform c
545478838 RefSeq NP_001269883 531 protein arginine N-methyltransferase 5 isoform d
545477926 RefSeq NP_001269884 593 protein arginine N-methyltransferase 5 isoform e
545478755 RefSeq NP_001269885 466 protein arginine N-methyltransferase 5 isoform f

Identical Sequences to LMP006274 proteins

Reference Database Accession Length Protein Name
GI:545479147 DBBJ BAG63261.1 576 unnamed protein product [Homo sapiens]
GI:545478755 GenBank EAW66220.1 466 protein arginine methyltransferase 5, isoform CRA_c [Homo sapiens]
GI:88900507 GenBank JAA07291.1 620 protein arginine methyltransferase 5 [Pan troglodytes]
GI:20070220 GenBank JAA13058.1 637 protein arginine methyltransferase 5 [Pan troglodytes]
GI:20070220 GenBank JAA27673.1 637 protein arginine methyltransferase 5 [Pan troglodytes]
GI:88900507 GenBank JAA27674.1 620 protein arginine methyltransferase 5 [Pan troglodytes]
GI:88900507 RefSeq XP_003260649.1 620 PREDICTED: protein arginine N-methyltransferase 5 isoform 2 [Nomascus leucogenys]
GI:545477926 RefSeq XP_003260650.1 593 PREDICTED: protein arginine N-methyltransferase 5 isoform 3 [Nomascus leucogenys]
GI:545479147 RefSeq XP_003260652.1 576 PREDICTED: protein arginine N-methyltransferase 5 isoform 5 [Nomascus leucogenys]
GI:88900507 RefSeq XP_003808153.1 620 PREDICTED: protein arginine N-methyltransferase 5 isoform X2 [Pan paniscus]
GI:545477926 RefSeq XP_003808154.1 593 PREDICTED: protein arginine N-methyltransferase 5 isoform X3 [Pan paniscus]
GI:545479147 RefSeq XP_003808156.1 576 PREDICTED: protein arginine N-methyltransferase 5 isoform X4 [Pan paniscus]
GI:20070220 RefSeq XP_004054963.1 637 PREDICTED: protein arginine N-methyltransferase 5 isoform 1 [Gorilla gorilla gorilla]
GI:545477926 RefSeq XP_004054965.1 593 PREDICTED: protein arginine N-methyltransferase 5 isoform 3 [Gorilla gorilla gorilla]
GI:545478838 RefSeq XP_004054966.1 531 PREDICTED: protein arginine N-methyltransferase 5 isoform 4 [Gorilla gorilla gorilla]
GI:545478838 RefSeq XP_005560878.1 531 PREDICTED: protein arginine N-methyltransferase 5 isoform X3 [Macaca fascicularis]
GI:20070220 RefSeq XP_008063454.1 637 PREDICTED: protein arginine N-methyltransferase 5 isoform X1 [Tarsius syrichta]
GI:88900507 RefSeq XP_008063455.1 620 PREDICTED: protein arginine N-methyltransferase 5 isoform X2 [Tarsius syrichta]
GI:545478838 RefSeq XP_008063457.1 531 PREDICTED: protein arginine N-methyltransferase 5 isoform X4 [Tarsius syrichta]
GI:545478838 RefSeq XP_008063458.1 531 PREDICTED: protein arginine N-methyltransferase 5 isoform X4 [Tarsius syrichta]
GI:545478838 RefSeq XP_009209411.1 531 PREDICTED: protein arginine N-methyltransferase 5 isoform X3 [Papio anubis]
GI:20070220 RefSeq XP_009425725.1 637 PREDICTED: protein arginine N-methyltransferase 5 isoform X1 [Pan troglodytes]
GI:88900507 RefSeq XP_009425726.1 620 PREDICTED: protein arginine N-methyltransferase 5 isoform X2 [Pan troglodytes]
GI:545478838 RefSeq XP_009425727.1 531 PREDICTED: protein arginine N-methyltransferase 5 isoform X3 [Pan troglodytes]
GI:20070220 RefSeq XP_010376666.1 637 PREDICTED: protein arginine N-methyltransferase 5 isoform X1 [Rhinopithecus roxellana]

Related Sequences to LMP006274 proteins

Reference Database Accession Length Protein Name
GI:545478838 DBBJ BAG70060.1 637 protein arginine methyltransferase 5 isoform a [Homo sapiens]
GI:545478838 DBBJ BAG70184.1 637 protein arginine methyltransferase 5 isoform a, partial [Homo sapiens]
GI:20070220 EMBL CAH92718.1 637 hypothetical protein [Pongo abelii]
GI:20070220 GenBank AAV38169.1 638 SKB1 homolog (S. pombe), partial [synthetic construct]
GI:545478838 GenBank EAW66218.1 637 protein arginine methyltransferase 5, isoform CRA_b [Homo sapiens]
GI:545478838 GenBank EAW66219.1 637 protein arginine methyltransferase 5, isoform CRA_b [Homo sapiens]
GI:88900507 GenBank AFH30778.1 620 protein arginine N-methyltransferase 5 isoform b [Macaca mulatta]
GI:88900507 GenBank AFI35973.1 620 protein arginine N-methyltransferase 5 isoform b [Macaca mulatta]
GI:20070220 RefSeq NP_001126589.1 637 protein arginine N-methyltransferase 5 [Pongo abelii]
GI:545478838 RefSeq XP_003260648.1 637 PREDICTED: protein arginine N-methyltransferase 5 isoform 1 [Nomascus leucogenys]
GI:88900507 RefSeq NP_001244996.1 620 protein arginine N-methyltransferase 5 [Macaca mulatta]
GI:545479147 RefSeq XP_003801962.1 576 PREDICTED: protein arginine N-methyltransferase 5 isoform 5 [Otolemur garnettii]
GI:88900507 RefSeq XP_003901616.1 620 PREDICTED: protein arginine N-methyltransferase 5 isoform X2 [Papio anubis]
GI:545479147 RefSeq XP_004010393.1 576 PREDICTED: protein arginine N-methyltransferase 5 isoform 4 [Ovis aries]
GI:88900507 RefSeq XP_004054964.1 620 PREDICTED: protein arginine N-methyltransferase 5 isoform 2 [Gorilla gorilla gorilla]
GI:545479147 RefSeq XP_004054967.1 576 PREDICTED: protein arginine N-methyltransferase 5 isoform 5 [Gorilla gorilla gorilla]
GI:545479147 RefSeq XP_004283236.1 576 PREDICTED: protein arginine N-methyltransferase 5 isoform 3 [Orcinus orca]
GI:545479147 RefSeq XP_004313408.1 576 PREDICTED: protein arginine N-methyltransferase 5 isoform 3 [Tursiops truncatus]
GI:545477926 RefSeq XP_004402161.1 593 PREDICTED: protein arginine N-methyltransferase 5 isoform 3 [Odobenus rosmarus divergens]
GI:545477926 RefSeq XP_004421301.1 593 PREDICTED: protein arginine N-methyltransferase 5 isoform 2 [Ceratotherium simum simum]
GI:20070220 RefSeq XP_005560876.1 644 PREDICTED: protein arginine N-methyltransferase 5 isoform X1 [Macaca fascicularis]
GI:88900507 RefSeq XP_005560877.1 620 PREDICTED: protein arginine N-methyltransferase 5 isoform X2 [Macaca fascicularis]
GI:545477926 RefSeq XP_005882317.1 593 PREDICTED: protein arginine N-methyltransferase 5 isoform X3 [Myotis brandtii]
GI:545478755 RefSeq XP_005882319.1 466 PREDICTED: protein arginine N-methyltransferase 5 isoform X5 [Myotis brandtii]
GI:545479147 RefSeq XP_005895511.1 576 PREDICTED: protein arginine N-methyltransferase 5 isoform X4 [Bos mutus]
GI:545478755 RefSeq XP_005895513.1 466 PREDICTED: protein arginine N-methyltransferase 5 isoform X6 [Bos mutus]
GI:545477926 RefSeq XP_005978051.1 593 PREDICTED: protein arginine N-methyltransferase 5 isoform X3 [Pantholops hodgsonii]
GI:545478755 RefSeq XP_005978054.1 466 PREDICTED: protein arginine N-methyltransferase 5 isoform X6 [Pantholops hodgsonii]
GI:545478755 RefSeq XP_006100140.1 466 PREDICTED: protein arginine N-methyltransferase 5 isoform X5 [Myotis lucifugus]
GI:545478755 RefSeq XP_006066564.1 466 PREDICTED: protein arginine N-methyltransferase 5 isoform X6 [Bubalus bubalis]
GI:545477926 RefSeq XP_007449592.1 593 PREDICTED: protein arginine N-methyltransferase 5 isoform X3 [Lipotes vexillifer]
GI:545478755 RefSeq XP_007449595.1 466 PREDICTED: protein arginine N-methyltransferase 5 isoform X6 [Lipotes vexillifer]
GI:545477926 RefSeq XP_007949368.1 593 PREDICTED: protein arginine N-methyltransferase 5 isoform X3 [Orycteropus afer afer]
GI:20070220 RefSeq XP_007988979.1 637 PREDICTED: protein arginine N-methyltransferase 5 isoform X1 [Chlorocebus sabaeus]
GI:545478838 RefSeq XP_008063454.1 637 PREDICTED: protein arginine N-methyltransferase 5 isoform X1 [Tarsius syrichta]
GI:20070220 SwissProt Q5R698.3 637 RecName: Full=Protein arginine N-methyltransferase 5; AltName: Full=Histone-arginine N-methyltransferase PRMT5; AltName: Full=Shk1 kinase-binding protein 1 homolog; Short=SKB1 homolog [Pongo abelii]