Gene/Proteome Database (LMPD)

LMPD ID
LMP006283
Gene ID
54613
Species
Mus musculus (Mouse)
Gene Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
Gene Symbol
St3gal6
Synonyms
1700023B24Rik; AI930218; AW552396; Siat10; St3galVI
Alternate Names
type 2 lactosamine alpha-2,3-sialyltransferase; ST3Gal VI; alpha-2,3-sialyltransferase VI; sialyltransferase 10 (alpha-2,3-sialyltransferase VI); CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI
Chromosome
16
Map Location
16 C1.2|16
EC Number
2.4.99.-

Proteins

type 2 lactosamine alpha-2,3-sialyltransferase
Refseq ID NP_061254
Protein GI 9055352
UniProt ID Q8VIB3
mRNA ID NM_018784
Length 329
RefSeq Status PROVISIONAL
MKGYLVAIFLSSIFLYYVLYCILWGTNGYWFPAEEMRTRNNVNNCFKKPAFANLLRFPQLYPFLCRADFIKVAAMSGTNNFPLPYGIKTFETYFSSALSKLQSCDLFDEFDRVPCKRCVVVGNGGVLKNKTLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSDSSHYDPNTTAVLVVFKPQDLRWLVEILLGKKINTQGFWKTPALKLIYKQYQIRILDPYITSEAAFQMLRFPRVFPKDQKPKHPTTGIIAITMAFHICSEVHLAGFKYNFYSPNSPLHYYGNATMSLMKQNAYHNLTAEQLFLNDIIKKKMVINLT

Gene Information

Entrez Gene ID
54613
Gene Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
Gene Symbol
St3gal6
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0030173 IEA:InterPro C integral component of Golgi membrane
GO:0052798 ISS:UniProtKB F beta-galactoside alpha-2,3-sialyltransferase activity
GO:0008373 ISO:MGI F sialyltransferase activity
GO:0006464 ISS:UniProtKB P cellular protein modification process
GO:0071354 ISS:UniProtKB P cellular response to interleukin-6
GO:0006664 ISS:UniProtKB P glycolipid metabolic process
GO:0009311 ISS:UniProtKB P oligosaccharide metabolic process
GO:0006486 IEA:InterPro P protein glycosylation
GO:0097503 ISO:GOC P sialylation

KEGG Pathway Links

KEGG Pathway ID Description
mmu01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5893854 Keratan sulfate biosynthesis
5894035 Pre-NOTCH Processing in Golgi
5893781 Sialic acid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR001675 Glycosyl transferase, family 29
IPR012163 Sialyltransferase

UniProt Annotations

Entry Information

Gene Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
Protein Entry
SIA10_MOUSE
UniProt ID
Q8VIB3
Species
Mouse

Comments

Comment Type Description
Function Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3- sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1 (By similarity). {ECO:0000250}.
Similarity Belongs to the glycosyltransferase 29 family. {ECO:0000305}.
Subcellular Location Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Web Resource Name=Functional Glycomics Gateway - GTase; Note=ST3Gal VI; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_647";

Identical and Related Proteins

Unique RefSeq proteins for LMP006283 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
9055352 RefSeq NP_061254 329 type 2 lactosamine alpha-2,3-sialyltransferase

Identical Sequences to LMP006283 proteins

Reference Database Accession Length Protein Name
GI:9055352 DBBJ BAE36994.1 329 unnamed protein product [Mus musculus]
GI:9055352 EMBL CBX32760.1 329 unnamed protein product [Mus musculus]
GI:9055352 EMBL CBX46693.1 329 unnamed protein product [Mus musculus]
GI:9055352 GenBank EDK98180.1 329 ST3 beta-galactoside alpha-2,3-sialyltransferase 6, isoform CRA_a [Mus musculus]
GI:9055352 RefSeq XP_006522450.1 329 PREDICTED: type 2 lactosamine alpha-2,3-sialyltransferase isoform X1 [Mus musculus]
GI:9055352 RefSeq XP_006522451.1 329 PREDICTED: type 2 lactosamine alpha-2,3-sialyltransferase isoform X2 [Mus musculus]

Related Sequences to LMP006283 proteins

Reference Database Accession Length Protein Name
GI:9055352 DBBJ BAB79494.1 331 alpha2,3-sialyltransferase [Mus musculus]
GI:9055352 GenBank AAH52338.1 329 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 [Mus musculus]
GI:9055352 GenBank EDK98181.1 387 ST3 beta-galactoside alpha-2,3-sialyltransferase 6, isoform CRA_b, partial [Mus musculus]
GI:9055352 GenBank EDK98182.1 387 ST3 beta-galactoside alpha-2,3-sialyltransferase 6, isoform CRA_b, partial [Mus musculus]
GI:9055352 RefSeq XP_006522452.1 319 PREDICTED: type 2 lactosamine alpha-2,3-sialyltransferase isoform X3 [Mus musculus]
GI:9055352 RefSeq XP_006522453.1 308 PREDICTED: type 2 lactosamine alpha-2,3-sialyltransferase isoform X4 [Mus musculus]