Gene/Proteome Database (LMPD)
Proteins
| UDP-glucose:glycoprotein glucosyltransferase 1 precursor | |
|---|---|
| Refseq ID | NP_942602 |
| Protein GI | 236466498 |
| UniProt ID | Q6P5E4 |
| mRNA ID | NM_198899 |
| Length | 1551 |
| RefSeq Status | VALIDATED |
| MCSRGDANTADAAAARRVTGLRYNMRLLIALALPCLFSLAEANSKAITTSLTTKWFSAPLLLEASEFLAEDSQEKFWSFVEATQNIGSSDHHDTDHSYYDAVLEAAFRFLSPLQQNLLKFCLSLRSYSASIQAFQQIAVDEPPPEGCKSFLSVHGKQTCDLDTLESLLLTAADRPKPLLFKGDHRYPSSNPESPVVILYSEIGHEEFSNIHHQLISKSNEGKINYVFRHYISNPSKEPVYLSGYGVELAIKSTEYKAKDDTQVKGTEVNATVIGESDPIDEVQGFLFGKLRELYPALEGQLKEFRKHLVESTNEMAPLKVWQLQDLSFQTAARILAASGALSLVVMKDISQNFPTKARAITKTAVSAQLRAEVEENQKYFKGTIGLQPGDSALFINGLHIDLDTQDIFSLFDTLRNEARVMEGLHRLGIEGLSLHNILKLNIQPSETDYAVDIRSPAISWVNNLEVDSRYNSWPSSLQELLRPTFPGVIRQIRKNLHNMVFIIDPVHETTAELISIAEMFLSNHIPLRIGFIFVVNDSEDVDGMQDAGVAVLRAYNYVAQEVDGYHAFQTLTQIYNKVRTGETVKVEHVVSVLEKKYPYVEVNSILGIDSAYDQNRKEARGYYEQTGVGPLPVVLFNGMPFEKEQLDPDELETITMHKILETTTFFQRAVYLGELSHDQDVVEYIMNQPNVVPRINSRILTAKREYLDLTASNNFYVDDFARFSALDSRGKTAAIANSMNYLTKKGMSSKEIYDDSFIRPVTFWIVGDFDSPSGRQLLYDAIKHQKTSNNVRISMINNPSQEISDSSTPIFRAIWAALQTQASSSAKNFITKMAKEETAEALAAGVDIAEFSVGGMDVSLFKEVFESSRMDFILSHALYCRDVLKLKKGQRVVISNGRIIGPLEDNELFNQDDFHLLENIILKTSGQKIKSHIQQLRVEEDVASDLVMKVDALLSAQPKGEARIEYQFFEDKHSAIKLKPKEGETYYDVVAVVDPVTREAQRLAPLLLVLTQLINMNLRVFMNCQSKLSDMPLKSFYRYVLEPEISFTADSSFAKGPIAKFLDMPQSPLFTLNLNTPESWMVESVRTPYDLDNIYLEEVDSIVAAEYELEYLLLEGHCYDITTGQPPRGLQFTLGTSANPTIVDTIVMANLGYFQLKANPGAWILRLRKGRSDDIYRIYSHDGTDSPPDANDVVVILNNFKSKIIKVKVQKKADMANEDLLSDGTNENESGFWDSFKWGFSGQKAEEVKQDKDDIINIFSVASGHLYERFLRIMMLSVLKNTKTPVKFWFLKNYLSPTFKEFIPYMAKKYNFQYELVQYKWPRWLHQQTEKQRIIWGYKILFLDVLFPLVVDKFLFVDADQIVRTDLKELRDFNLDGAPYGYTPFCDSRREMDGYRFWKSGYWASHLAGRKYHISALYVVDLKKFRKIAAGDRLRGQYQGLSQDPNSLSNLDQDLPNNMIHQVPIKSLPQEWLWCETWCDDASKKRAKTIDLCNNPMTKEPKLEAAVRIVPEWQDYDQEIKQLQTLFQEEKELGTLHTEETQEGSQKHEEL | |
| sig_peptide: 1..42 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 4468 peptide sequence: MCSRGDANTADAAAARRVTGLRYNMRLLIALALPCLFSLAEA mat_peptide: 43..1551 product: UDP-glucose:glycoprotein glucosyltransferase 1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q6P5E4.4) calculated_mol_wt: 171984 peptide sequence: NSKAITTSLTTKWFSAPLLLEASEFLAEDSQEKFWSFVEATQNIGSSDHHDTDHSYYDAVLEAAFRFLSPLQQNLLKFCLSLRSYSASIQAFQQIAVDEPPPEGCKSFLSVHGKQTCDLDTLESLLLTAADRPKPLLFKGDHRYPSSNPESPVVILYSEIGHEEFSNIHHQLISKSNEGKINYVFRHYISNPSKEPVYLSGYGVELAIKSTEYKAKDDTQVKGTEVNATVIGESDPIDEVQGFLFGKLRELYPALEGQLKEFRKHLVESTNEMAPLKVWQLQDLSFQTAARILAASGALSLVVMKDISQNFPTKARAITKTAVSAQLRAEVEENQKYFKGTIGLQPGDSALFINGLHIDLDTQDIFSLFDTLRNEARVMEGLHRLGIEGLSLHNILKLNIQPSETDYAVDIRSPAISWVNNLEVDSRYNSWPSSLQELLRPTFPGVIRQIRKNLHNMVFIIDPVHETTAELISIAEMFLSNHIPLRIGFIFVVNDSEDVDGMQDAGVAVLRAYNYVAQEVDGYHAFQTLTQIYNKVRTGETVKVEHVVSVLEKKYPYVEVNSILGIDSAYDQNRKEARGYYEQTGVGPLPVVLFNGMPFEKEQLDPDELETITMHKILETTTFFQRAVYLGELSHDQDVVEYIMNQPNVVPRINSRILTAKREYLDLTASNNFYVDDFARFSALDSRGKTAAIANSMNYLTKKGMSSKEIYDDSFIRPVTFWIVGDFDSPSGRQLLYDAIKHQKTSNNVRISMINNPSQEISDSSTPIFRAIWAALQTQASSSAKNFITKMAKEETAEALAAGVDIAEFSVGGMDVSLFKEVFESSRMDFILSHALYCRDVLKLKKGQRVVISNGRIIGPLEDNELFNQDDFHLLENIILKTSGQKIKSHIQQLRVEEDVASDLVMKVDALLSAQPKGEARIEYQFFEDKHSAIKLKPKEGETYYDVVAVVDPVTREAQRLAPLLLVLTQLINMNLRVFMNCQSKLSDMPLKSFYRYVLEPEISFTADSSFAKGPIAKFLDMPQSPLFTLNLNTPESWMVESVRTPYDLDNIYLEEVDSIVAAEYELEYLLLEGHCYDITTGQPPRGLQFTLGTSANPTIVDTIVMANLGYFQLKANPGAWILRLRKGRSDDIYRIYSHDGTDSPPDANDVVVILNNFKSKIIKVKVQKKADMANEDLLSDGTNENESGFWDSFKWGFSGQKAEEVKQDKDDIINIFSVASGHLYERFLRIMMLSVLKNTKTPVKFWFLKNYLSPTFKEFIPYMAKKYNFQYELVQYKWPRWLHQQTEKQRIIWGYKILFLDVLFPLVVDKFLFVDADQIVRTDLKELRDFNLDGAPYGYTPFCDSRREMDGYRFWKSGYWASHLAGRKYHISALYVVDLKKFRKIAAGDRLRGQYQGLSQDPNSLSNLDQDLPNNMIHQVPIKSLPQEWLWCETWCDDASKKRAKTIDLCNNPMTKEPKLEAAVRIVPEWQDYDQEIKQLQTLFQEEKELGTLHTEETQEGSQKHEEL | |
Gene Information
Entrez Gene ID
Gene Name
UDP-glucose glycoprotein glucosyltransferase 1
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005788 | ISS:UniProtKB | C | endoplasmic reticulum lumen |
| GO:0005793 | ISS:UniProtKB | C | endoplasmic reticulum-Golgi intermediate compartment |
| GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
| GO:0003980 | ISS:UniProtKB | F | UDP-glucose:glycoprotein glucosyltransferase activity |
| GO:0051082 | ISS:UniProtKB | F | unfolded protein binding |
| GO:0006486 | IEA:UniProtKB-UniPathway | P | protein glycosylation |
Domain Information
UniProt Annotations
Entry Information
Gene Name
UDP-glucose glycoprotein glucosyltransferase 1
Protein Entry
Q6P5E4_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Cofactor | Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ; |
| Domain | The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects. |
| Function | Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (By similarity). |
| Pathway | Protein modification; protein glycosylation. |
| Similarity | Belongs to the glycosyltransferase 8 family. |
| Subcellular Location | Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:Q9NYU2, ECO:0000255|PROSITE- ProRule:PRU10138}. Endoplasmic reticulum-Golgi intermediate compartment . |
| Subunit | Monomer as well as in a tight complex with SEP15. Interacts with METTL23 (By similarity). |
Identical and Related Proteins
Unique RefSeq proteins for LMP006292 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 236466498 | RefSeq | NP_942602 | 1551 | UDP-glucose:glycoprotein glucosyltransferase 1 precursor |
Identical Sequences to LMP006292 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:236466498 | SwissProt | Q6P5E4.4 | 1551 | RecName: Full=UDP-glucose:glycoprotein glucosyltransferase 1; Short=UGT1; AltName: Full=UDP--Glc:glycoprotein glucosyltransferase; AltName: Full=UDP-glucose ceramide glucosyltransferase-like 1; Flags: Precursor [Mus musculus] |
Related Sequences to LMP006292 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:236466498 | GenBank | AAH62936.1 | 1551 | UDP-glucose ceramide glucosyltransferase-like 1 [Mus musculus] |
| GI:236466498 | GenBank | AAH68283.1 | 1551 | UDP-glucose ceramide glucosyltransferase-like 1 [Mus musculus] |
| GI:236466498 | GenBank | EDL14473.1 | 1591 | UDP-glucose ceramide glucosyltransferase-like 1, isoform CRA_a, partial [Mus musculus] |
| GI:236466498 | RefSeq | XP_006244796.1 | 1551 | PREDICTED: UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1 [Rattus norvegicus] |
| GI:236466498 | RefSeq | XP_006496125.1 | 1543 | PREDICTED: UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1 [Mus musculus] |
| GI:236466498 | SwissProt | Q9JLA3.2 | 1551 | RecName: Full=UDP-glucose:glycoprotein glucosyltransferase 1; Short=UGT1; Short=rUGT1; AltName: Full=UDP--Glc:glycoprotein glucosyltransferase; AltName: Full=UDP-glucose ceramide glucosyltransferase-like 1; Flags: Precursor [Rattus norvegicus] |