Gene/Proteome Database (LMPD)

LMPD ID
LMP006293
Gene ID
162466
Species
Homo sapiens (Human)
Gene Name
phosphatase, orphan 1
Gene Symbol
PHOSPHO1
Synonyms
-
Alternate Names
phosphoethanolamine/phosphocholine phosphatase
Chromosome
17
Map Location
17q21.32
EC Number
3.1.3.75

Proteins

phosphoethanolamine/phosphocholine phosphatase isoform 1
Refseq ID NP_001137276
Protein GI 219689097
UniProt ID Q8TCT1
mRNA ID NM_001143804
Length 292
RefSeq Status VALIDATED
MCQRLWPWPANQPLPGGLLPRPLSLAPSSSSSCCSPPCSQDGRMAAQGAPRFLLTFDFDETIVDENSDDSIVRAAPGQRLPESLRATYREGFYNEYMQRVFKYLGEQGVRPRDLSAIYEAIPLSPGMSDLLQFVAKQGACFEVILISDANTFGVESSLRAAGHHSLFRRILSNPSGPDARGLLALRPFHTHSCARCPANMCKHKVLSDYLRERAHDGVHFERLFYVGDGANDFCPMGLLAGGDVAFPRRGYPMHRLIQEAQKAEPSSFRASVVPWETAADVRLHLQQVLKSC
phosphoethanolamine/phosphocholine phosphatase isoform 2
Refseq ID NP_848595
Protein GI 30425420
UniProt ID Q8TCT1
mRNA ID NM_178500
Length 267
RefSeq Status VALIDATED
MSGCFPVSGLRCLSRDGRMAAQGAPRFLLTFDFDETIVDENSDDSIVRAAPGQRLPESLRATYREGFYNEYMQRVFKYLGEQGVRPRDLSAIYEAIPLSPGMSDLLQFVAKQGACFEVILISDANTFGVESSLRAAGHHSLFRRILSNPSGPDARGLLALRPFHTHSCARCPANMCKHKVLSDYLRERAHDGVHFERLFYVGDGANDFCPMGLLAGGDVAFPRRGYPMHRLIQEAQKAEPSSFRASVVPWETAADVRLHLQQVLKSC

Gene Information

Entrez Gene ID
162466
Gene Name
phosphatase, orphan 1
Gene Symbol
PHOSPHO1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 TAS:Reactome C cytosol
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0052731 EXP:Reactome F phosphocholine phosphatase activity
GO:0052732 EXP:Reactome F phosphoethanolamine phosphatase activity
GO:0016462 IDA:MGI F pyrophosphatase activity
GO:0035630 IEA:Ensembl P bone mineralization involved in bone maturation
GO:0016311 EXP:GOC P dephosphorylation
GO:0001958 IEA:Ensembl P endochondral ossification
GO:0046474 TAS:Reactome P glycerophospholipid biosynthetic process
GO:0006656 TAS:Reactome P phosphatidylcholine biosynthetic process
GO:0006646 TAS:Reactome P phosphatidylethanolamine biosynthetic process
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0030500 IEA:UniProtKB-KW P regulation of bone mineralization
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00564 Glycerophospholipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_121401 Glycerophospholipid biosynthesis
REACT_121238 Synthesis of PC
REACT_120919 Synthesis of PE

Domain Information

InterPro Annotations

Accession Description
IPR023214 HAD-like domain
IPR006383 HAD-superfamily hydrolase, subfamily IB, PSPase-like
IPR016965 Phosphatase PHOSPHO-type
IPR006384 Pyridoxal phosphate phosphatase-related

UniProt Annotations

Entry Information

Gene Name
phosphatase, orphan 1
Protein Entry
PHOP1_HUMAN
UniProt ID
Q8TCT1
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8TCT1-1; Sequence=Displayed; Name=2; Synonyms=PHOSPHO1-3a; IsoId=Q8TCT1-2; Sequence=VSP_040624; Name=3; IsoId=Q8TCT1-3; Sequence=VSP_045709; Note=No experimental confirmation available.;
Biophysicochemical Properties Kinetic parameters: KM=3 uM for PEA ; KM=11.4 uM for PCho ; pH dependence: Optimum pH is 6.7. ;
Catalytic Activity O-phosphoethanolamine + H(2)O = ethanolamine + phosphate.
Catalytic Activity Phosphocholine + H(2)O = choline + phosphate.
Cofactor Name=Mg(2+); Xref=ChEBI
Function Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization.
Similarity Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.
Tissue Specificity Expressed at sites of mineralization in bone and cartilage. Highly expressed in osteoblast cell line SaOS-2 which produces a mineralized matrix, but not in MG-63 cell line, which do not mineralize.

Identical and Related Proteins

Unique RefSeq proteins for LMP006293 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
219689097 RefSeq NP_001137276 292 phosphoethanolamine/phosphocholine phosphatase isoform 1
30425420 RefSeq NP_848595 267 phosphoethanolamine/phosphocholine phosphatase isoform 2

Identical Sequences to LMP006293 proteins

Reference Database Accession Length Protein Name
GI:30425420 GenBank ABJ41968.1 267 Sequence 36 from patent US 7112668
GI:30425420 GenBank ABJ41969.1 267 Sequence 38 from patent US 7112668
GI:30425420 GenBank EAW94686.1 267 phosphatase, orphan 1 [Homo sapiens]
GI:30425420 GenBank AHE03261.1 267 Sequence 63349 from patent US 8586006
GI:30425420 GenBank AIC53304.1 267 PHOSPHO1, partial [synthetic construct]
GI:30425420 RefSeq XP_005257166.1 267 PREDICTED: phosphoethanolamine/phosphocholine phosphatase isoform X3 [Homo sapiens]

Related Sequences to LMP006293 proteins

Reference Database Accession Length Protein Name
GI:30425420 RefSeq XP_001172566.1 267 PREDICTED: phosphoethanolamine/phosphocholine phosphatase isoform X2 [Pan troglodytes]
GI:219689097 RefSeq XP_511946.3 292 PREDICTED: phosphoethanolamine/phosphocholine phosphatase isoform X1 [Pan troglodytes]
GI:219689097 RefSeq XP_003810092.1 292 PREDICTED: phosphoethanolamine/phosphocholine phosphatase isoform X2 [Pan paniscus]
GI:30425420 RefSeq XP_004041468.1 267 PREDICTED: phosphoethanolamine/phosphocholine phosphatase isoform 1 [Gorilla gorilla gorilla]
GI:30425420 RefSeq XP_004041470.1 267 PREDICTED: phosphoethanolamine/phosphocholine phosphatase isoform 3 [Gorilla gorilla gorilla]
GI:30425420 RefSeq XP_004041471.1 267 PREDICTED: phosphoethanolamine/phosphocholine phosphatase isoform 4 [Gorilla gorilla gorilla]
GI:219689097 RefSeq XP_006721794.1 350 PREDICTED: phosphoethanolamine/phosphocholine phosphatase isoform X4 [Homo sapiens]
GI:219689097 RefSeq XP_006721795.1 350 PREDICTED: phosphoethanolamine/phosphocholine phosphatase isoform X5 [Homo sapiens]
GI:219689097 RefSeq XP_008960654.1 350 PREDICTED: phosphoethanolamine/phosphocholine phosphatase isoform X1 [Pan paniscus]
GI:219689097 RefSeq XP_008960655.1 350 PREDICTED: phosphoethanolamine/phosphocholine phosphatase isoform X1 [Pan paniscus]
GI:30425420 RefSeq XP_009430066.1 267 PREDICTED: phosphoethanolamine/phosphocholine phosphatase isoform X2 [Pan troglodytes]
GI:30425420 RefSeq XP_009430067.1 267 PREDICTED: phosphoethanolamine/phosphocholine phosphatase isoform X2 [Pan troglodytes]