Gene/Proteome Database (LMPD)
LMPD ID
LMP006294
Gene ID
Species
Homo sapiens (Human)
Gene Name
solute carrier family 27 (fatty acid transporter), member 4
Gene Symbol
Synonyms
ACSVL4; FATP4; IPS
Alternate Names
long-chain fatty acid transport protein 4
Chromosome
9
Map Location
9q34.11
EC Number
6.2.1.-
Summary
This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq, Apr 2010]
Orthologs
Proteins
| long-chain fatty acid transport protein 4 | |
|---|---|
| Refseq ID | NP_005085 |
| Protein GI | 40807357 |
| UniProt ID | Q6P1M0 |
| mRNA ID | NM_005094 |
| Length | 643 |
| RefSeq Status | REVIEWED |
| MLLGASLVGVLLFSKLVLKLPWTQVGFSLLFLYLGSGGWRFIRVFIKTIRRDIFGGLVLLKVKAKVRQCLQERRTVPILFASTVRRHPDKTALIFEGTDTHWTFRQLDEYSSSVANFLQARGLASGDVAAIFMENRNEFVGLWLGMAKLGVEAALINTNLRRDALLHCLTTSRARALVFGSEMASAICEVHASLDPSLSLFCSGSWEPGAVPPSTEHLDPLLKDAPKHLPSCPDKGFTDKLFYIYTSGTTGLPKAAIVVHSRYYRMAALVYYGFRMRPNDIVYDCLPLYHSAGNIVGIGQCLLHGMTVVIRKKFSASRFWDDCIKYNCTIVQYIGELCRYLLNQPPREAENQHQVRMALGNGLRQSIWTNFSSRFHIPQVAEFYGATECNCSLGNFDSQVGACGFNSRILSFVYPIRLVRVNEDTMELIRGPDGVCIPCQPGEPGQLVGRIIQKDPLRRFDGYLNQGANNKKIAKDVFKKGDQAYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVSTTEVEGTLSRLLDMADVAVYGVEVPGTEGRAGMAAVASPTGNCDLERFAQVLEKELPLYARPIFLRLLPELHKTGTYKFQKTELRKEGFDPAIVKDPLFYLDAQKGRYVPLDQEAYSRIQAGEEKL | |
Gene Information
Entrez Gene ID
Gene Name
solute carrier family 27 (fatty acid transporter), member 4
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0031526 | IEA:Ensembl | C | brush border membrane |
| GO:0005789 | IDA:UniProtKB | C | endoplasmic reticulum membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0016020 | IDA:UniProtKB | C | membrane |
| GO:0005902 | IEA:Ensembl | C | microvillus |
| GO:0005886 | TAS:Reactome | C | plasma membrane |
| GO:0015245 | TAS:ProtInc | F | fatty acid transporter activity |
| GO:0004467 | IDA:UniProtKB | F | long-chain fatty acid-CoA ligase activity |
| GO:0000166 | IEA:UniProtKB-KW | F | nucleotide binding |
| GO:0031957 | IEA:Ensembl | F | very long-chain fatty acid-CoA ligase activity |
| GO:0015908 | TAS:ProtInc | P | fatty acid transport |
| GO:0006629 | TAS:ProtInc | P | lipid metabolic process |
| GO:0044539 | IDA:UniProtKB | P | long-chain fatty acid import |
| GO:0001676 | IDA:UniProtKB | P | long-chain fatty acid metabolic process |
| GO:0015909 | TAS:Reactome | P | long-chain fatty acid transport |
| GO:0001579 | IEA:Ensembl | P | medium-chain fatty acid transport |
| GO:0007584 | IEA:Ensembl | P | response to nutrient |
| GO:0043588 | IEA:Ensembl | P | skin development |
| GO:0055085 | TAS:Reactome | P | transmembrane transport |
| GO:0006810 | TAS:ProtInc | P | transport |
| GO:0042760 | IEA:Ensembl | P | very long-chain fatty acid catabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa04975 | Fat digestion and absorption |
| ko04975 | Fat digestion and absorption |
| hsa03320 | PPAR signaling pathway |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_23892 | Transport of fatty acids |
Domain Information
UniProt Annotations
Entry Information
Gene Name
solute carrier family 27 (fatty acid transporter), member 4
Protein Entry
S27A4_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P1M0-1; Sequence=Displayed; Name=2; IsoId=Q6P1M0-2; Sequence=VSP_055808, VSP_055809; Note=No experimental confirmation available.; |
| Disease | Ichthyosis prematurity syndrome (IPS) [MIM |
| Function | Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity). |
| Miscellaneous | SLC27A4/FATP4-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which is associated with disturbed fatty acid metabolism and homeostasis, such as obesity. SLC27A4/FATP4 expression is positively correlated with acquired obesity. |
| Sequence Caution | Sequence=AAD11623.1; Type=Frameshift; Positions=362, 387, 612, 619; Evidence= ; |
| Similarity | Belongs to the ATP-dependent AMP-binding enzyme family. |
| Subcellular Location | Membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane . |
| Tissue Specificity | Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tissue. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006294 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 40807357 | RefSeq | NP_005085 | 643 | long-chain fatty acid transport protein 4 |
Identical Sequences to LMP006294 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:40807357 | DBBJ | BAF82911.1 | 643 | unnamed protein product [Homo sapiens] |
| GI:40807357 | GenBank | ABH70728.1 | 643 | Sequence 27 from patent US 7033772 |
| GI:40807357 | GenBank | ABH70737.1 | 643 | Sequence 41 from patent US 7033772 |
| GI:40807357 | GenBank | ABH70744.1 | 643 | Sequence 53 from patent US 7033772 |
| GI:40807357 | GenBank | EAW87779.1 | 643 | solute carrier family 27 (fatty acid transporter), member 4, isoform CRA_a [Homo sapiens] |
| GI:40807357 | GenBank | EAW87780.1 | 643 | solute carrier family 27 (fatty acid transporter), member 4, isoform CRA_a [Homo sapiens] |
Related Sequences to LMP006294 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:40807357 | GenBank | ACM86212.1 | 670 | Sequence 11710 from patent US 6812339 |
| GI:40807357 | GenBank | JAA07008.1 | 643 | solute carrier family 27 (fatty acid transporter), member 4 [Pan troglodytes] |
| GI:40807357 | GenBank | JAA18286.1 | 643 | solute carrier family 27 (fatty acid transporter), member 4 [Pan troglodytes] |
| GI:40807357 | GenBank | JAA23134.1 | 643 | solute carrier family 27 (fatty acid transporter), member 4 [Pan troglodytes] |
| GI:40807357 | GenBank | JAA41112.1 | 643 | solute carrier family 27 (fatty acid transporter), member 4 [Pan troglodytes] |
| GI:40807357 | RefSeq | XP_001157155.1 | 643 | PREDICTED: long-chain fatty acid transport protein 4 isoform X1 [Pan troglodytes] |