Gene/Proteome Database (LMPD)

LMPD ID
LMP006298
Gene ID
67442
Species
Mus musculus (Mouse)
Gene Name
retinol saturase (all trans retinol 13,14 reductase)
Gene Symbol
Retsat
Synonyms
0610039N19Rik; C80029; MMT-7; Ppsig
Alternate Names
all-trans-retinol 13,14-reductase; all-trans-13,14-dihydroretinol saturase; PPAR-alpha-regulated and starvation-induced gene protein
Chromosome
6
Map Location
6|6 C3
EC Number
1.3.99.23

Proteins

all-trans-retinol 13,14-reductase precursor
Refseq ID NP_080435
Protein GI 52627143
UniProt ID Q64FW2
mRNA ID NM_026159
Length 609
RefSeq Status VALIDATED
MWITALLLAVLLLVILHRVYVGLYAASSPNPFAEDVKRPPEPLVTDKEARKKVLKQAFSVSRVPEKLDAVVIGSGIGGLASAAVLAKAGKRVLVLEQHTKAGGCCHTFGENGLEFDTGIHYIGRMREGNIGRFILDQITEGQLDWAPMASPFDLMILEGPNGRKEFPMYSGRKEYIQGLKKKFPKEEAVIDKYMELVKVVARGVSHAVLLKFLPLPLTQLLSKFGLLTRFSPFCRASTQSLAEVLQQLGASRELQAVLSYIFPTYGVTPSHTAFSLHALLVDHYIQGAYYPRGGSSEIAFHTIPLIQRAGGAVLTRATVQSVLLDSAGRACGVSVKKGQELVNIYCPVVISNAGMFNTYQHLLPETVRHLPDVKKQLAMVRPGLSMLSIFICLKGTKEDLKLQSTNYYVYFDTDMDKAMERYVSMPKEKAPEHIPLLFIAFPSSKDPTWEERFPDRSTMTALVPMAFEWFEEWQEEPKGKRGVDYETLKNAFVEASMSVIMKLFPQLEGKVESVTGGSPLTNQYYLAAPRGATYGADHDLARLHPHAMASIRAQTPIPNLYLTGQDIFTCGLMGALQGALLCSSAILKRNLYSDLQALGSKVKAQKKKM
sig_peptide: 1..25 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (Q64FW2.3) calculated_mol_wt: 2855 peptide sequence: MWITALLLAVLLLVILHRVYVGLYA mat_peptide: 26..609 product: All-trans-retinol 13,14-reductase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q64FW2.3) calculated_mol_wt: 64498 peptide sequence: ASSPNPFAEDVKRPPEPLVTDKEARKKVLKQAFSVSRVPEKLDAVVIGSGIGGLASAAVLAKAGKRVLVLEQHTKAGGCCHTFGENGLEFDTGIHYIGRMREGNIGRFILDQITEGQLDWAPMASPFDLMILEGPNGRKEFPMYSGRKEYIQGLKKKFPKEEAVIDKYMELVKVVARGVSHAVLLKFLPLPLTQLLSKFGLLTRFSPFCRASTQSLAEVLQQLGASRELQAVLSYIFPTYGVTPSHTAFSLHALLVDHYIQGAYYPRGGSSEIAFHTIPLIQRAGGAVLTRATVQSVLLDSAGRACGVSVKKGQELVNIYCPVVISNAGMFNTYQHLLPETVRHLPDVKKQLAMVRPGLSMLSIFICLKGTKEDLKLQSTNYYVYFDTDMDKAMERYVSMPKEKAPEHIPLLFIAFPSSKDPTWEERFPDRSTMTALVPMAFEWFEEWQEEPKGKRGVDYETLKNAFVEASMSVIMKLFPQLEGKVESVTGGSPLTNQYYLAAPRGATYGADHDLARLHPHAMASIRAQTPIPNLYLTGQDIFTCGLMGALQGALLCSSAILKRNLYSDLQALGSKVKAQKKKM

Gene Information

Entrez Gene ID
67442
Gene Name
retinol saturase (all trans retinol 13,14 reductase)
Gene Symbol
Retsat
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IDA:HGNC C endoplasmic reticulum membrane
GO:0031965 IDA:HGNC C nuclear membrane
GO:0005640 IDA:HGNC C nuclear outer membrane
GO:0051786 IDA:HGNC F all-trans-retinol 13,14-reductase activity
GO:0016491 IDA:HGNC F oxidoreductase activity
GO:0055114 IDA:HGNC P oxidation-reduction process
GO:0042572 IDA:HGNC P retinol metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00830 Retinol metabolism
mmu00830 Retinol metabolism

Domain Information

InterPro Annotations

Accession Description

UniProt Annotations

Entry Information

Gene Name
retinol saturase (all trans retinol 13,14 reductase)
Protein Entry
RETST_MOUSE
UniProt ID
Q64FW2
Species
Mouse

Comments

Comment Type Description
Catalytic Activity All-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor. {ECO:0000269|PubMed:15358783}.
Cofactor Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250}; Name=NADP(+); Xref=ChEBI:CHEBI:58349; Evidence={ECO:0000250}; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
Function Retinol saturase carrying out the saturation of the 13- 14 double bond of all-trans-retinol to produce all-trans-13,14- dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A. {ECO:0000269|PubMed:15358783}.
Induction Up-regulated during starvation. {ECO:0000269|PubMed:18289917}.
Sequence Caution Sequence=BAB22406.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:15358783}; Peripheral membrane protein {ECO:0000269|PubMed:15358783}.
Tissue Specificity Predominantly expressed in the liver and kidney. Also expressed in intestine, white fat and brown fat. Weakly expressed in heart, skeletal muscle and testis and barely detected in the lung, brain and spleen. {ECO:0000269|PubMed:15358783, ECO:0000269|PubMed:18289917}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006298 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
52627143 RefSeq NP_080435 609 all-trans-retinol 13,14-reductase precursor

Identical Sequences to LMP006298 proteins

Reference Database Accession Length Protein Name
GI:52627143 GenBank EDK98989.1 609 retinol saturase (all trans retinol 13,14 reductase) [Mus musculus]
GI:52627143 GenBank ABS17600.1 609 PPSIG-3 isoform [Mus musculus]
GI:52627143 GenBank ABS17601.1 609 PPSIG-2 isoform [Mus musculus]
GI:52627143 GenBank ABS17602.1 609 PPSIG-1 isoform [Mus musculus]
GI:52627143 GenBank ABS17603.1 609 PPSIG [Mus musculus]
GI:52627143 SwissProt Q64FW2.3 609 RecName: Full=All-trans-retinol 13,14-reductase; AltName: Full=All-trans-13,14-dihydroretinol saturase; Short=RetSat; AltName: Full=PPAR-alpha-regulated and starvation-induced gene protein; Flags: Precursor [Mus musculus]

Related Sequences to LMP006298 proteins

Reference Database Accession Length Protein Name
GI:52627143 DBBJ BAE25708.1 609 unnamed protein product [Mus musculus]
GI:52627143 GenBank AAL73986.1 609 hypothetical protein MMT-7 [Mus musculus]
GI:52627143 GenBank AAI17751.1 607 Retsat protein, partial [Mus musculus]
GI:52627143 GenBank EDL91048.1 609 all-trans-13,14-dihydroretinol saturase, isoform CRA_b [Rattus norvegicus]
GI:52627143 RefSeq NP_659552.1 609 all-trans-retinol 13,14-reductase precursor [Rattus norvegicus]
GI:52627143 SwissProt Q8VHE9.1 609 RecName: Full=All-trans-retinol 13,14-reductase; AltName: Full=All-trans-13,14-dihydroretinol saturase; Short=RetSat; AltName: Full=PPAR-alpha-regulated and starvation-induced gene protein; AltName: Full=RMT-7; Flags: Precursor [Rattus norvegicus]