Gene/Proteome Database (LMPD)

LMPD ID
LMP006309
Gene ID
18807
Species
Mus musculus (Mouse)
Gene Name
phospholipase D family, member 3
Gene Symbol
Pld3
Synonyms
Sam-9
Alternate Names
phospholipase D3; PLD 3; choline phosphatase 3; schwannoma-associated protein 9; phosphatidylcholine-hydrolyzing phospholipase D3
Chromosome
7
Map Location
7 A3|7
EC Number
3.1.4.4

Proteins

phospholipase D3
Refseq ID NP_035246
Protein GI 7242181
UniProt ID O35405
mRNA ID NM_011116
Length 488
RefSeq Status PROVISIONAL
MKPKLMYQELKVPVEEPAGELPLNEIEAWKAAEKKARWVLLVLILAVVGFGALMTQLFLWEYGDLHLFGPNQRPAPCYDPCEAVLVESIPEGLEFPNATTSNPSTSQAWLGLLAGAHSSLDIASFYWTLTNNDTHTQEPSAQQGEEVLQQLQALAPRGVKVRIAVSKPNGPLADLQSLLQSGAQVRMVDMQKLTHGVLHTKFWVVDQTHFYLGSANMDWRSLTQVKELGVVMYNCSCLARDLTKIFEAYWFLGQAGSSIPSTWPRSFDTRYNQETPMEICLNGTPALAYLASAPPPLCPSGRTPDLKALLNVVDSARSFIYIAVMNYLPTMEFSHPRRFWPAIDDGLRRAAYERGVKVRLLISCWGHSDPSMRSFLLSLAALHDNHTHSDIQVKLFVVPTDESQARIPYARVNHNKYMVTERASYIGTSNWSGSYFTETAGTSLLVTQNGHGGLRSQLEAVFLRDWESPYSHDLDTSANSVGNACRLL

Gene Information

Entrez Gene ID
18807
Gene Name
phospholipase D family, member 3
Gene Symbol
Pld3
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0070290 IEA:UniProtKB-EC F N-acylphosphatidylethanolamine-specific phospholipase D activity
GO:0004630 ISS:MGI F phospholipase D activity
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00565 Ether lipid metabolism
mmu00564 Glycerophospholipid metabolism
mmu01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5893983 Synthesis of PG

Domain Information

InterPro Annotations

Accession Description
IPR001736 Phospholipase D/Transphosphatidylase

UniProt Annotations

Entry Information

Gene Name
phospholipase D family, member 3
Protein Entry
PLD3_MOUSE
UniProt ID
O35405
Species
Mouse

Comments

Comment Type Description
Catalytic Activity A phosphatidylcholine + H(2)O = choline + a phosphatidate.
Function Probably involved in APP processing. {ECO:0000250}.
Ptm Glycosylated. {ECO:0000250}.
Similarity Belongs to the phospholipase D family. {ECO:0000305}.
Similarity Contains 2 PLD phosphodiesterase domains. {ECO:0000255|PROSITE-ProRule:PRU00153}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Subunit Interacts with APP. {ECO:0000250}.
Tissue Specificity Expressed at higher level in brain than in non-nervous tissue. Probably highly expressed in neurons. Expressed in mature neurons of the forebrain and appears to be turned on at late stages of neurogenesis. Expressed during late neuronal development in the forebrain. {ECO:0000269|PubMed:9813063}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006309 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
7242181 RefSeq NP_035246 488 phospholipase D3

Identical Sequences to LMP006309 proteins

Reference Database Accession Length Protein Name
GI:7242181 GenBank AAH76586.1 488 Pld3 protein [Mus musculus]
GI:7242181 GenBank ABA36716.1 488 Sequence 5 from patent US 6936453
GI:7242181 GenBank EDL24179.1 488 phospholipase D family, member 3 [Mus musculus]
GI:7242181 RefSeq XP_006539705.1 488 PREDICTED: phospholipase D3 isoform X1 [Mus musculus]
GI:7242181 RefSeq XP_006539706.1 488 PREDICTED: phospholipase D3 isoform X2 [Mus musculus]
GI:7242181 SwissProt O35405.1 488 RecName: Full=Phospholipase D3; Short=PLD 3; AltName: Full=Choline phosphatase 3; AltName: Full=Phosphatidylcholine-hydrolyzing phospholipase D3; AltName: Full=Schwannoma-associated protein 9; Short=SAM-9 [Mus musculus]

Related Sequences to LMP006309 proteins

Reference Database Accession Length Protein Name
GI:7242181 DBBJ BAE32053.1 488 unnamed protein product [Mus musculus]
GI:7242181 RefSeq XP_005371651.1 488 PREDICTED: phospholipase D3 isoform X1 [Microtus ochrogaster]
GI:7242181 RefSeq XP_005371652.1 488 PREDICTED: phospholipase D3 isoform X2 [Microtus ochrogaster]
GI:7242181 RefSeq XP_006228640.1 488 PREDICTED: phospholipase D3 isoform X1 [Rattus norvegicus]
GI:7242181 RefSeq XP_006995883.1 488 PREDICTED: phospholipase D3 isoform X1 [Peromyscus maniculatus bairdii]
GI:7242181 RefSeq XP_006995884.1 488 PREDICTED: phospholipase D3 isoform X2 [Peromyscus maniculatus bairdii]