Gene/Proteome Database (LMPD)

LMPD ID
LMP006313
Gene ID
13115
Species
Mus musculus (Mouse)
Gene Name
cytochrome P450, family 27, subfamily b, polypeptide 1
Gene Symbol
Cyp27b1
Synonyms
Cp2b; Cyp1; Cyp27b; Cyp40; P450c1; Pddr; Vdd1; Vddr; VddrI; Vdr
Alternate Names
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; P450VD1alpha; 1alpha(OH)ase; VD3 1A hydroxylase; cytochrome p450 27B1; cytochrome P450, 27b1; cytochrome P450C1 alpha; cytochrome P450VD1-alpha; calcidiol 1-monooxygenase; 25(OH)D 1alpha-hydroxylase; 25-OHD-1 alpha-hydroxylase; 25-hydroxyvitamin D3 1alpha-hydroxylase; 25-hydroxyvitamin D(3) 1-alpha-hydroxylase; cytochrome P450 subfamily XXVIIB polypeptide 1; cytochrome P450, 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase); 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D3 1-alpha-hydroxylase) (VD3 1A hydroxylase) (P450C1 alpha) (P450VD1-alpha)
Chromosome
10
Map Location
10 D3|10
EC Number
1.14.13.13

Proteins

25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Refseq ID NP_034139
Protein GI 227497562
UniProt ID O35084
mRNA ID NM_010009
Length 507
RefSeq Status VALIDATED
MTQAVKLASRVFHRIHLPLQLDASLGSRGSESVLRSLSDIPGPSTLSFLAELFCKGGLSRLHELQVHGAARYGPIWSGSFGTLRTVYVADPTLVEQLLRQESHCPERCSFSSWAEHRRRHQRACGLLTADGEEWQRLRSLLAPLLLRPQAAAGYAGTLDNVVRDLVRRLRRQRGRGSGLPGLVLDVAGEFYKFGLESIGAVLLGSRLGCLEAEVPPDTETFIHAVGSVFVSTLLTMAMPNWLHHLIPGPWARLCRDWDQMFAFAQRHVELREGEAAMRNQGKPEEDMPSGHHLTHFLFREKVSVQSIVGNVTELLLAGVDTVSNTLSWTLYELSRHPDVQTALHSEITAGTRGSCAHPHGTALSQLPLLKAVIKEVLRLYPVVPGNSRVPDRDIRVGNYVIPQDTLVSLCHYATSRDPTQFPDPNSFNPARWLGEGPTPHPFASLPFGFGKRSCIGRRLAELELQMALSQILTHFEVLPEPGALPIKPMTRTVLVPERSINLQFVDR

Gene Information

Entrez Gene ID
13115
Gene Name
cytochrome P450, family 27, subfamily b, polypeptide 1
Gene Symbol
Cyp27b1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0005739 IDA:MGI C mitochondrion
GO:0004498 IDA:BHF-UCL F calcidiol 1-monooxygenase activity
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0070314 IEA:Ensembl P G1 to G0 transition
GO:0030282 IEA:Ensembl P bone mineralization
GO:0036378 IDA:GOC P calcitriol biosynthetic process from calciol
GO:0055074 IEA:Ensembl P calcium ion homeostasis
GO:0006816 IMP:MGI P calcium ion transport
GO:0046697 IEA:Ensembl P decidualization
GO:0010956 IEA:Ensembl P negative regulation of calcidiol 1-monooxygenase activity
GO:0030308 IEA:Ensembl P negative regulation of cell growth
GO:0008285 IEA:Ensembl P negative regulation of cell proliferation
GO:0045618 IEA:Ensembl P positive regulation of keratinocyte differentiation
GO:0010980 IEA:Ensembl P positive regulation of vitamin D 24-hydroxylase activity
GO:0070564 IEA:Ensembl P positive regulation of vitamin D receptor signaling pathway
GO:0030500 IEA:Ensembl P regulation of bone mineralization
GO:0043627 IEA:Ensembl P response to estrogen
GO:0034341 IEA:Ensembl P response to interferon-gamma
GO:0032496 IEA:Ensembl P response to lipopolysaccharide
GO:0033280 IDA:BHF-UCL P response to vitamin D
GO:0042369 IDA:BHF-UCL P vitamin D catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00100 Steroid biosynthesis
mmu05152 Tuberculosis

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 27, subfamily b, polypeptide 1
Protein Entry
CP27B_MOUSE
UniProt ID
O35084
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Calcidiol + NADPH + O(2) = calcitriol + NADP(+) + H(2)O.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
Function Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D) to 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D) plays an important role in normal bone growth, calcium metabolism, and tissue differentiation.
Pathway Hormone biosynthesis; cholecalciferol biosynthesis.
Sequence Caution Sequence=BAA22434.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location Mitochondrion membrane.
Tissue Specificity Kidney.

Identical and Related Proteins

Unique RefSeq proteins for LMP006313 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
227497562 RefSeq NP_034139 507 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

Identical Sequences to LMP006313 proteins

Reference Database Accession Length Protein Name
GI:227497562 GenBank AAG44889.1 507 25-hydroxyvitamin D 1-alpha-hydroxylase [Mus musculus]
GI:227497562 GenBank AAK15024.1 507 25-hydroxyvitamin D3 1-alpha-hydroxylase [Mus musculus]
GI:227497562 GenBank EDL24463.1 507 cytochrome P450, family 27, subfamily b, polypeptide 1 [Mus musculus]
GI:227497562 SwissProt O35084.2 507 RecName: Full=25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; AltName: Full=25-OHD-1 alpha-hydroxylase; AltName: Full=25-hydroxyvitamin D(3) 1-alpha-hydroxylase; Short=VD3 1A hydroxylase; AltName: Full=Calcidiol 1-monooxygenase; AltName: Full=Cytochrome P450 subfamily XXVIIB polypeptide 1; AltName: Full=Cytochrome P450C1 alpha; AltName: Full=Cytochrome P450VD1-alpha; AltName: Full=Cytochrome p450 27B1; Flags: Precursor [Mus musculus]

Related Sequences to LMP006313 proteins

Reference Database Accession Length Protein Name
GI:227497562 DBBJ BAA22434.1 516 25-hydroxyvitamin D3 1alpha-hydroxylase, partial [Mus musculus]
GI:227497562 DBBJ BAA23271.1 501 VD3 1a hydroxylase [Rattus norvegicus]
GI:227497562 EMBL CAC39904.1 501 unnamed protein product, partial [Rattus norvegicus]
GI:227497562 EMBL CAC39906.1 501 unnamed protein product [Rattus norvegicus]
GI:227497562 GenBank AAE79370.1 501 Sequence 1 from patent US 6274359
GI:227497562 SwissProt O35132.2 501 RecName: Full=25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; AltName: Full=25-OHD-1 alpha-hydroxylase; AltName: Full=25-hydroxyvitamin D(3) 1-alpha-hydroxylase; Short=VD3 1A hydroxylase; AltName: Full=Calcidiol 1-monooxygenase; AltName: Full=Cytochrome P450 subfamily XXVIIB polypeptide 1; AltName: Full=Cytochrome P450C1 alpha; AltName: Full=Cytochrome P450VD1-alpha; AltName: Full=Cytochrome p450 27B1; Flags: Precursor [Rattus norvegicus]