Gene/Proteome Database (LMPD)

LMPD ID
LMP006325
Gene ID
55808
Species
Homo sapiens (Human)
Gene Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Gene Symbol
ST6GALNAC1
Synonyms
HSY11339; SIAT7A; ST6GalNAcI; STYI
Alternate Names
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; SIAT7-A; ST6GalNAc I; sialyltransferase 7A; galNAc alpha-2,6-sialyltransferase I; GalNAc alpha-2, 6-sialyltransferase I, long form; sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) A
Chromosome
17
Map Location
17q25.1
EC Number
2.4.99.3
Summary
Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]).[supplied by OMIM, Mar 2008]
Orthologs
View orthologs and multiple alignments for ST6GALNAC1

Proteins

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 isoform 1
Refseq ID NP_060884
Protein GI 21264332
UniProt ID Q9NSC7
mRNA ID NM_018414
Length 600
RefSeq Status VALIDATED
MRSCLWRCRHLSQGVQWSLLLAVLVFFLFALPSFIKEPQTKPSRHQRTENIKERSLQSLAKPKSQAPTRARRTTIYAEPVPENNALNTQTQPKAHTTGDRGKEANQAPPEEQDKVPHTAQRAAWKSPEKEKTMVNTLSPRGQDAGMASGRTEAQSWKSQDTKTTQGNGGQTRKLTASRTVSEKHQGKAATTAKTLIPKSQHRMLAPTGAVSTRTRQKGVTTAVIPPKEKKPQATPPPAPFQSPTTQRNQRLKAANFKSEPRWDFEEKYSFEIGGLQTTCPDSVKIKASKSLWLQKLFLPNLTLFLDSRHFNQSEWDRLEHFAPPFGFMELNYSLVQKVVTRFPPVPQQQLLLASLPAGSLRCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSFYGFTAFSLTQSLLILGNRGFKNVPLGKDVRYLHFLEGTRDYEWLEALLMNQTVMSKNLFWFRHRPQEAFREALHMDRYLLLHPDFLRYMKNRFLRSKTLDGAHWRIYRPTTGALLLLTALQLCDQVSAYGFITEGHERFSDHYYDTSWKRLIFYINHDFKLEREVWKRLHDEGIIRLYQRPGPGTAKAKN

Gene Information

Entrez Gene ID
55808
Gene Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Gene Symbol
ST6GALNAC1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0001665 IEA:UniProtKB-EC F alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
GO:0008373 NAS:UniProtKB F sialyltransferase activity
GO:0009312 IEA:Ensembl P oligosaccharide biosynthetic process
GO:0006486 NAS:UniProtKB P protein glycosylation
GO:0097503 NAS:GOC P sialylation

KEGG Pathway Links

KEGG Pathway ID Description
hsa01100 Metabolic pathways
hsa00512 Mucin type O-Glycan biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_200874 Sialic acid metabolism
REACT_22387 Synthesis of substrates in N-glycan biosythesis

Domain Information

InterPro Annotations

Accession Description
IPR001675 Glycosyl transferase, family 29

UniProt Annotations

Entry Information

Gene Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Protein Entry
SIA7A_HUMAN
UniProt ID
Q9NSC7
Species
Human

Comments

Comment Type Description
Catalytic Activity CMP-N-acetylneuraminate + glycano-(1->3)-(N- acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano- ((2->6)-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)- glycoprotein.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 29 family.
Subcellular Location Golgi apparatus membrane ; Single-pass type II membrane protein .
Web Resource Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org//Genes/ST6GALNAC1ID44087ch17q25.html";
Web Resource Name=Functional Glycomics Gateway - GTase; Note=ST6GalNAc I; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_630";
Web Resource Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST6GALNAC1";

Identical and Related Proteins

Unique RefSeq proteins for LMP006325 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21264332 RefSeq NP_060884 600 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 isoform 1

Identical Sequences to LMP006325 proteins

Reference Database Accession Length Protein Name
GI:21264332 EMBL CAS91682.1 600 unnamed protein product [Homo sapiens]
GI:21264332 GenBank EAW89419.1 600 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1, isoform CRA_a [Homo sapiens]
GI:21264332 GenBank AFG79803.1 600 Sequence 62 from patent US 8137928
GI:21264332 GenBank AFN90536.1 600 Sequence 59 from patent US 8198045
GI:21264332 GenBank AHE02321.1 600 Sequence 60675 from patent US 8586006
GI:21264332 SwissProt Q9NSC7.1 600 RecName: Full=Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; AltName: Full=GalNAc alpha-2,6-sialyltransferase I; AltName: Full=ST6GalNAc I; Short=ST6GalNAcI; AltName: Full=Sialyltransferase 7A; Short=SIAT7-A [Homo sapiens]

Related Sequences to LMP006325 proteins

Reference Database Accession Length Protein Name
GI:21264332 GenBank ABH65894.1 600 Sequence 347 from patent US 7029873
GI:21264332 GenBank ABH72000.1 600 Sequence 347 from patent US 7034106
GI:21264332 GenBank ABH72444.1 600 Sequence 347 from patent US 7034122
GI:21264332 GenBank ABH72821.1 600 Sequence 347 from patent US 7034136
GI:21264332 GenBank ABH75559.1 600 Sequence 347 from patent US 7041804
GI:21264332 GenBank ABH83062.1 600 Sequence 462 from patent US 7045603