Gene/Proteome Database (LMPD)

LMPD ID
LMP006328
Gene ID
26020
Species
Homo sapiens (Human)
Gene Name
low density lipoprotein receptor-related protein 10
Gene Symbol
LRP10
Synonyms
LRP9; MST087
Alternate Names
low-density lipoprotein receptor-related protein 10; LRP-10
Chromosome
14
Map Location
14q11.2

Proteins

low-density lipoprotein receptor-related protein 10 precursor
Refseq ID NP_054764
Protein GI 32490559
UniProt ID Q7Z4F1
mRNA ID NM_014045
Length 713
RefSeq Status VALIDATED
MLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHLACGSERLTLRSPLQPLISLCEAPPSPLQLPGGNVTITYSYAGARAPMGQGFLLSYSQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGGGPGARRRQRGRLMRRLVRRLRRWGLLPRTNTPARASEARSQVTPSAAPLEALDGGTGPAREGGAVGGQDGEQAPPLPIKAPLPSASTSPAPTTVPEAPGPLPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSPPGPHTAVLALEDEDDVLLVPLAEPGVWVAEAEDEPLLT
sig_peptide: 1..16 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1596 peptide sequence: MLLATLLLLLLGGALA mat_peptide: 17..713 product: low-density lipoprotein receptor-related protein 10 calculated_mol_wt: 74616 peptide sequence: HPDRIIFPNHACEDPPAVLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHLACGSERLTLRSPLQPLISLCEAPPSPLQLPGGNVTITYSYAGARAPMGQGFLLSYSQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGGGPGARRRQRGRLMRRLVRRLRRWGLLPRTNTPARASEARSQVTPSAAPLEALDGGTGPAREGGAVGGQDGEQAPPLPIKAPLPSASTSPAPTTVPEAPGPLPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSPPGPHTAVLALEDEDDVLLVPLAEPGVWVAEAEDEPLLT

Gene Information

Entrez Gene ID
26020
Gene Name
low density lipoprotein receptor-related protein 10
Gene Symbol
LRP10
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005905 IEA:UniProtKB-KW C coated pit
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 IDA:UniProtKB C membrane
GO:0006897 IEA:UniProtKB-KW P endocytosis

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_160102 Diseases associated with visual transduction
REACT_24968 Retinoid metabolism and transport
REACT_111102 Signal Transduction
REACT_160125 Visual phototransduction

Domain Information

InterPro Annotations

Accession Description
IPR000859 CUB domain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site

UniProt Annotations

Entry Information

Gene Name
low density lipoprotein receptor-related protein 10
Protein Entry
LRP10_HUMAN
UniProt ID
Q7Z4F1
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7Z4F1-1; Sequence=Displayed; Name=2; IsoId=Q7Z4F1-2; Sequence=VSP_009820; Note=No experimental confirmation available.;
Function Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity).
Sequence Caution Sequence=AAD20037.1; Type=Erroneous initiation; Evidence= ; Sequence=AAG17980.1; Type=Frameshift; Positions=370, 700; Evidence= ; Sequence=AAQ13610.1; Type=Frameshift; Positions=312, 337, 496, 502, 512; Evidence= ; Sequence=CAD39174.2; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence= ;
Similarity Belongs to the LDLR family.
Similarity Contains 2 CUB domains. {ECO
Similarity Contains 4 LDL-receptor class A domains.
Subcellular Location Membrane ; Single-pass type I membrane protein . Membrane, coated pit .
Tissue Specificity Expressed in blood leukocyte, lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, skeletal muscle and heart.

Identical and Related Proteins

Unique RefSeq proteins for LMP006328 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
32490559 RefSeq NP_054764 713 low-density lipoprotein receptor-related protein 10 precursor

Identical Sequences to LMP006328 proteins

Reference Database Accession Length Protein Name
GI:32490559 GenBank ADL97846.1 713 Sequence 416 from patent US 7718770
GI:32490559 GenBank ADM02111.1 713 Sequence 183 from patent US 7723488
GI:32490559 GenBank AED39334.1 713 Sequence 1477 from patent US 7883858
GI:32490559 GenBank AEH74957.1 713 Sequence 26 from patent US 7956237
GI:32490559 GenBank AEJ71442.1 713 Sequence 1226 from patent US 7968689
GI:32490559 GenBank AEU55293.1 713 Sequence 416 from patent US 8063186

Related Sequences to LMP006328 proteins

Reference Database Accession Length Protein Name
GI:32490559 EMBL CAD23340.1 713 unnamed protein product [Homo sapiens]
GI:32490559 GenBank EAW66234.1 721 low density lipoprotein receptor-related protein 10, isoform CRA_c [Homo sapiens]
GI:32490559 GenBank JAA10943.1 715 low density lipoprotein receptor-related protein 10 [Pan troglodytes]
GI:32490559 GenBank JAA15202.1 715 low density lipoprotein receptor-related protein 10 [Pan troglodytes]
GI:32490559 GenBank JAA31960.1 715 low density lipoprotein receptor-related protein 10 [Pan troglodytes]
GI:32490559 RefSeq XP_005267567.1 721 PREDICTED: low-density lipoprotein receptor-related protein 10 isoform X1 [Homo sapiens]