Gene/Proteome Database (LMPD)

LMPD ID
LMP006343
Gene ID
10924
Species
Homo sapiens (Human)
Gene Name
sphingomyelin phosphodiesterase, acid-like 3A
Gene Symbol
SMPDL3A
Synonyms
ASM3A; ASML3a; yR36GH4.1
Alternate Names
acid sphingomyelinase-like phosphodiesterase 3a; 0610010C24Rik; ASM-like phosphodiesterase 3a
Chromosome
6
Map Location
6q22.31
EC Number
3.1.4.-

Proteins

acid sphingomyelinase-like phosphodiesterase 3a isoform a precursor
Refseq ID NP_006705
Protein GI 24307911
UniProt ID Q92484
mRNA ID NM_006714
Length 453
RefSeq Status VALIDATED
MALVRALVCCLLTAWHCRSGLGLPVAPAGGRNPPPAIGQFWHVTDLHLDPTYHITDDHTKVCASSKGANASNPGPFGDVLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTDTVINVITNMTTTIQSLFPNLQVFPALGNHDYWPQDQLPVVTSKVYNAVANLWKPWLDEEAISTLRKGGFYSQKVTTNPNLRIISLNTNLYYGPNIMTLNKTDPANQFEWLESTLNNSQQNKEKVYIIAHVPVGYLPSSQNITAMREYYNEKLIDIFQKYSDVIAGQFYGHTHRDSIMVLSDKKGSPVNSLFVAPAVTPVKSVLEKQTNNPGIRLFQYDPRDYKLLDMLQYYLNLTEANLKGESIWKLEYILTQTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFFVSYDSSVTCDKTCKAFQICAIMNLDNISYADCLKQLYIKHNY
sig_peptide: 1..22 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2374 peptide sequence: MALVRALVCCLLTAWHCRSGLG mat_peptide: 23..453 product: Acid sphingomyelinase-like phosphodiesterase 3a experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q92484.2) calculated_mol_wt: 48905 peptide sequence: LPVAPAGGRNPPPAIGQFWHVTDLHLDPTYHITDDHTKVCASSKGANASNPGPFGDVLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTDTVINVITNMTTTIQSLFPNLQVFPALGNHDYWPQDQLPVVTSKVYNAVANLWKPWLDEEAISTLRKGGFYSQKVTTNPNLRIISLNTNLYYGPNIMTLNKTDPANQFEWLESTLNNSQQNKEKVYIIAHVPVGYLPSSQNITAMREYYNEKLIDIFQKYSDVIAGQFYGHTHRDSIMVLSDKKGSPVNSLFVAPAVTPVKSVLEKQTNNPGIRLFQYDPRDYKLLDMLQYYLNLTEANLKGESIWKLEYILTQTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFFVSYDSSVTCDKTCKAFQICAIMNLDNISYADCLKQLYIKHNY
acid sphingomyelinase-like phosphodiesterase 3a isoform b
Refseq ID NP_001273067
Protein GI 554790358
UniProt ID Q92484
mRNA ID NM_001286138
Length 322
RefSeq Status VALIDATED
MTTTIQSLFPNLQVFPALGNHDYWPQDQLPVVTSKVYNAVANLWKPWLDEEAISTLRKGGFYSQKVTTNPNLRIISLNTNLYYGPNIMTLNKTDPANQFEWLESTLNNSQQNKEKVYIIAHVPVGYLPSSQNITAMREYYNEKLIDIFQKYSDVIAGQFYGHTHRDSIMVLSDKKGSPVNSLFVAPAVTPVKSVLEKQTNNPGIRLFQYDPRDYKLLDMLQYYLNLTEANLKGESIWKLEYILTQTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFFVSYDSSVTCDKTCKAFQICAIMNLDNISYADCLKQLYIKHNY

Gene Information

Entrez Gene ID
10924
Gene Name
sphingomyelin phosphodiesterase, acid-like 3A
Gene Symbol
SMPDL3A
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IEA:InterPro C extracellular space
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0016798 IEA:UniProtKB-KW F hydrolase activity, acting on glycosyl bonds
GO:0004767 IEA:InterPro F sphingomyelin phosphodiesterase activity
GO:0006685 IEA:InterPro P sphingomyelin catabolic process

Domain Information

InterPro Annotations

Accession Description
IPR017064 Acid sphingomyelinase-like phosphodiesterase, predicted
IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR029052 Metallo-dependent phosphatase-like

UniProt Annotations

Entry Information

Gene Name
sphingomyelin phosphodiesterase, acid-like 3A
Protein Entry
ASM3A_HUMAN
UniProt ID
Q92484
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q92484-1; Sequence=Displayed; Name=2; IsoId=Q92484-2; Sequence=VSP_054640; Note=No experimental confirmation available.;
Similarity Belongs to the acid sphingomyelinase family.
Subcellular Location Secreted .

Identical and Related Proteins

Unique RefSeq proteins for LMP006343 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
24307911 RefSeq NP_006705 453 acid sphingomyelinase-like phosphodiesterase 3a isoform a precursor
554790358 RefSeq NP_001273067 322 acid sphingomyelinase-like phosphodiesterase 3a isoform b

Identical Sequences to LMP006343 proteins

Reference Database Accession Length Protein Name
GI:554790358 DBBJ BAH13465.1 322 unnamed protein product [Homo sapiens]
GI:24307911 GenBank AAP00466.1 453 Sequence 5 from patent US 6518029
GI:24307911 GenBank EAW48163.1 453 sphingomyelin phosphodiesterase, acid-like 3A, isoform CRA_a [Homo sapiens]
GI:554790358 GenBank EAW48164.1 322 sphingomyelin phosphodiesterase, acid-like 3A, isoform CRA_b [Homo sapiens]
GI:24307911 GenBank ABM83133.1 453 sphingomyelin phosphodiesterase, acid-like 3A [synthetic construct]
GI:24307911 GenBank ABM86328.1 453 sphingomyelin phosphodiesterase, acid-like 3A, partial [synthetic construct]
GI:24307911 GenBank AIC50753.1 453 SMPDL3A, partial [synthetic construct]
GI:24307911 SwissProt Q92484.2 453 RecName: Full=Acid sphingomyelinase-like phosphodiesterase 3a; Short=ASM-like phosphodiesterase 3a; Flags: Precursor [Homo sapiens]

Related Sequences to LMP006343 proteins

Reference Database Accession Length Protein Name
GI:554790358 GenBank AAE52103.1 453 Sequence 5 from patent US 6132964
GI:554790358 GenBank AAH18999.1 453 Sphingomyelin phosphodiesterase, acid-like 3A [Homo sapiens]
GI:24307911 GenBank ABH74994.1 453 Sequence 1 from patent US 7041497
GI:554790358 GenBank ABM83133.1 453 sphingomyelin phosphodiesterase, acid-like 3A [synthetic construct]
GI:554790358 GenBank ABM86328.1 453 sphingomyelin phosphodiesterase, acid-like 3A, partial [synthetic construct]
GI:24307911 GenBank AEK14218.1 453 Sequence 1 from patent US 7972844
GI:24307911 GenBank AHL56734.1 453 Sequence 1 from patent US 8642739
GI:554790358 GenBank AIC50753.1 453 SMPDL3A, partial [synthetic construct]
GI:24307911 RefSeq XP_518720.2 453 PREDICTED: acid sphingomyelinase-like phosphodiesterase 3a isoform X1 [Pan troglodytes]
GI:24307911 RefSeq XP_002817363.1 453 PREDICTED: acid sphingomyelinase-like phosphodiesterase 3a isoform X1 [Pongo abelii]
GI:24307911 RefSeq XP_003827648.1 453 PREDICTED: acid sphingomyelinase-like phosphodiesterase 3a isoform X1 [Pan paniscus]
GI:554790358 SwissProt Q92484.2 453 RecName: Full=Acid sphingomyelinase-like phosphodiesterase 3a; Short=ASM-like phosphodiesterase 3a; Flags: Precursor [Homo sapiens]