Gene/Proteome Database (LMPD)

LMPD ID
LMP006344
Gene ID
27293
Species
Homo sapiens (Human)
Gene Name
sphingomyelin phosphodiesterase, acid-like 3B
Gene Symbol
SMPDL3B
Synonyms
ASML3B
Alternate Names
acid sphingomyelinase-like phosphodiesterase 3b; ASM-like phosphodiesterase 3b
Chromosome
1
Map Location
1p35.3
EC Number
3.1.4.-

Proteins

acid sphingomyelinase-like phosphodiesterase 3b isoform 1 precursor
Refseq ID NP_055289
Protein GI 57242798
UniProt ID Q92485
mRNA ID NM_014474
Length 455
RefSeq Status VALIDATED
MRLLAWLIFLANWGGARAEPGKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWGDYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIREVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKLPGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQNKAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFITPGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLKDMVTYFMNLSQANAQGTPRWELEYQLTEAYGVPDASAHSMHTVLDRIAGDQSTLQRYYVYNSVSYSAGVCDEACSMQHVCAMRQVDIDAYTTCLYASGTTPVPQLPLLLMALLGLCTLVL
sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2060 peptide sequence: MRLLAWLIFLANWGGARA sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2060 peptide sequence: MRLLAWLIFLANWGGARA mat_peptide: 19..455 product: Acid sphingomyelinase-like phosphodiesterase 3b experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q92485.2) calculated_mol_wt: 48773 peptide sequence: EPGKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWGDYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIREVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKLPGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQNKAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFITPGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLKDMVTYFMNLSQANAQGTPRWELEYQLTEAYGVPDASAHSMHTVLDRIAGDQSTLQRYYVYNSVSYSAGVCDEACSMQHVCAMRQVDIDAYTTCLYASGTTPVPQLPLLLMALLGLCTLVL
acid sphingomyelinase-like phosphodiesterase 3b isoform 2 precursor
Refseq ID NP_001009568
Protein GI 57242800
UniProt ID Q92485
mRNA ID NM_001009568
Length 373
RefSeq Status VALIDATED
MRLLAWLIFLANWGGARAEPGKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWGDYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIREVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKLPGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQNKAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFITPGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLKVRSPAEARGGGWEGLKCITTFPHSQLIHLPLTTEPQEG

Gene Information

Entrez Gene ID
27293
Gene Name
sphingomyelin phosphodiesterase, acid-like 3B
Gene Symbol
SMPDL3B
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IDA:UniProt C extracellular space
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0016798 IEA:UniProtKB-KW F hydrolase activity, acting on glycosyl bonds
GO:0004767 IEA:InterPro F sphingomyelin phosphodiesterase activity
GO:0006685 IEA:InterPro P sphingomyelin catabolic process

Domain Information

InterPro Annotations

Accession Description
IPR017064 Acid sphingomyelinase-like phosphodiesterase, predicted
IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR029052 Metallo-dependent phosphatase-like

UniProt Annotations

Entry Information

Gene Name
sphingomyelin phosphodiesterase, acid-like 3B
Protein Entry
ASM3B_HUMAN
UniProt ID
Q92485
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q92485-1; Sequence=Displayed; Name=2; IsoId=Q92485-2; Sequence=VSP_013478, VSP_013479; Note=No experimental confirmation available.;
Similarity Belongs to the acid sphingomyelinase family.
Subcellular Location Secreted .

Identical and Related Proteins

Unique RefSeq proteins for LMP006344 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
57242798 RefSeq NP_055289 455 acid sphingomyelinase-like phosphodiesterase 3b isoform 1 precursor
57242800 RefSeq NP_001009568 373 acid sphingomyelinase-like phosphodiesterase 3b isoform 2 precursor

Identical Sequences to LMP006344 proteins

Reference Database Accession Length Protein Name
GI:57242798 DBBJ BAH14871.1 455 unnamed protein product [Homo sapiens]
GI:57242800 GenBank AAH14444.1 373 Sphingomyelin phosphodiesterase, acid-like 3B [Homo sapiens]
GI:57242798 GenBank EAX07721.1 455 sphingomyelin phosphodiesterase, acid-like 3B, isoform CRA_a [Homo sapiens]
GI:57242800 GenBank EAX07723.1 373 sphingomyelin phosphodiesterase, acid-like 3B, isoform CRA_c [Homo sapiens]
GI:57242800 GenBank AIC51210.1 373 SMPDL3B, partial [synthetic construct]
GI:57242800 GenBank AIC51211.1 373 SMPDL3B, partial [synthetic construct]
GI:57242798 SwissProt Q92485.2 455 RecName: Full=Acid sphingomyelinase-like phosphodiesterase 3b; Short=ASM-like phosphodiesterase 3b; Flags: Precursor [Homo sapiens]

Related Sequences to LMP006344 proteins

Reference Database Accession Length Protein Name
GI:57242800 DBBJ BAG62896.1 455 unnamed protein product [Homo sapiens]
GI:57242798 DBBJ BAG62896.1 455 unnamed protein product [Homo sapiens]
GI:57242800 DBBJ BAH14871.1 455 unnamed protein product [Homo sapiens]
GI:57242798 EMBL CAA69328.1 465 acid sphingomyelinase-like phosphodiesterase [Homo sapiens]
GI:57242800 EMBL CAA69328.1 465 acid sphingomyelinase-like phosphodiesterase [Homo sapiens]
GI:57242800 GenBank EAX07721.1 455 sphingomyelin phosphodiesterase, acid-like 3B, isoform CRA_a [Homo sapiens]
GI:57242800 RefSeq NP_055289.2 455 acid sphingomyelinase-like phosphodiesterase 3b isoform 1 precursor [Homo sapiens]
GI:57242798 RefSeq XP_001151336.1 455 PREDICTED: acid sphingomyelinase-like phosphodiesterase 3b isoform X1 [Pan troglodytes]
GI:57242798 RefSeq XP_003271736.1 455 PREDICTED: acid sphingomyelinase-like phosphodiesterase 3b [Nomascus leucogenys]
GI:57242798 RefSeq XP_003828129.1 455 PREDICTED: acid sphingomyelinase-like phosphodiesterase 3b isoform X1 [Pan paniscus]
GI:57242798 RefSeq XP_004025331.1 455 PREDICTED: acid sphingomyelinase-like phosphodiesterase 3b [Gorilla gorilla gorilla]
GI:57242800 SwissProt Q92485.2 455 RecName: Full=Acid sphingomyelinase-like phosphodiesterase 3b; Short=ASM-like phosphodiesterase 3b; Flags: Precursor [Homo sapiens]