Gene/Proteome Database (LMPD)

LMPD ID
LMP006370
Gene ID
77626
Species
Mus musculus (Mouse)
Gene Name
sphingomyelin phosphodiesterase 4
Gene Symbol
Smpd4
Synonyms
4122402O22Rik; mKIAA1418
Alternate Names
sphingomyelin phosphodiesterase 4; nSMase3; nSMase-3; neutral sphingomyelinase 3; neutral sphingomyelinase III; neutral membrane (neutral sphingomyelinase-3)
Chromosome
16
Map Location
16|16 B1
EC Number
3.1.4.12

Proteins

sphingomyelin phosphodiesterase 4 isoform 1
Refseq ID NP_084221
Protein GI 257196240
UniProt ID Q6ZPR5
mRNA ID NM_029945
Length 823
RefSeq Status VALIDATED
MAFPHLQQPSFLLASLKADSINKPFAQRCQDLVKVIEDFPAKELHAVFPWLVESIFGSLDGVLVGWNLRCLQGRVNPVEYSTAMEFLDPSGPMMKLVYKLQAEDYNFDFPVSCLPGPVKASIQENVLPDSPLYHNKVQFPPTGGLGLNLALNPFEYYMFYFALSLISQKPMSMTLHVRTSDCAYFTLVDRYLSWFLPTEGSVPPPLCSSPGGSSPSPAPRTPAMPFASYGLHTSLLKRHISHQTSVNADPASHEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPHAKLEVLHYRLTVSSALHSPAQPSLQALHAYQESFTPTEEHVLVVRLLLKHLHAFANSLKPDQASPSAHSHATSPLEEFKRAAVPRFVQQKLYVFLQHCFGHWPLDATFRAVLEMWLSYLQPWRYAPEKQAQGSDPQPRCVSEKWAPFIQENLLMYTKLFVSFLNRALRTDLVSPKNALMVFRVAKVFAQPNLAEMIQKGEQLFLEPELIIPHRQHRLFTVTTSFLSPWPPVVTDASFKVKSHVYSLEGQDCKYTPMFGPEIRTLVLRLAQLITQAKQTAKSISDQYVESPTGRSFLSWLTFGLTDTNSCYPANDLDEIGQDSIRKTDEYLEKALEYLRQIFRLSEAQLAQLTLALGSARDENGKQQLPDCIVGEEGLILTPLGRYQIINGLRRFEIEYQGDLELQPIRSYEITSLVRALFRLSSAINRRFAGQMAALCSRNDFLGSFCRYHLTEPALSNRHLLSPVGRRQVTNPARGPRLSLRFLGSYRTLLLLLMAFFVASLFCIGPLSCSLLLVLGYVLYAIAMTLLTERGKLHQL
sphingomyelin phosphodiesterase 4 isoform 2
Refseq ID NP_001158083
Protein GI 257196247
UniProt ID Q6ZPR5
mRNA ID NM_001164611
Length 793
RefSeq Status VALIDATED
MAFPHLQQPSFLLASLKADSINKPFAQRCQDLVKVIEDFPAKELHAVFPWLVESIFGSLDGVLVGWNLRCLQGRVNPVEYSTAMEFLDPSGPMMKLVYKLQAEDYNFDFPVSCLPGPVKASIQENVLPDSPLYHNKVQFPPTGGLGLNLALNPFEYYMFYFALSLISQKPMSMTLHVRTSDCAYFTLVDRYLSWFLPTEGSVPPPLCSSPGGSSPSPAPRTPAMPFASYGLHTSLLKRHISHQTSVNADPASHEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPHAKESFTPTEEHVLVVRLLLKHLHAFANSLKPDQASPSAHSHATSPLEEFKRAAVPRFVQQKLYVFLQHCFGHWPLDATFRAVLEMWLSYLQPWRYAPEKQAQGSDPQPRCVSEKAPFIQENLLMYTKLFVSFLNRALRTDLVSPKNALMVFRVAKVFAQPNLAEMIQKGEQLFLEPELIIPHRQHRLFTVTTSFLSPWPPVVTDASFKVKSHVYSLEGQDCKYTPMFGPEIRTLVLRLAQLITQAKQTAKSISDQYVESPTGRSFLSWLTFGLTDTNSCYPANDLDEIGQDSIRKTDEYLEKALEYLRQIFRLSEAQLAQLTLALGSARDENGKQQLPDCIVGEEGLILTPLGRYQIINGLRRFEIEYQGDLELQPIRSYEITSLVRALFRLSSAINRRFAGQMAALCSRNDFLGSFCRYHLTEPALSNRHLLSPVGRRQVTNPARGPRLSLRFLGSYRTLLLLLMAFFVASLFCIGPLSCSLLLVLGYVLYAIAMTLLTERGKLHQL
sphingomyelin phosphodiesterase 4 isoform 3
Refseq ID NP_001158082
Protein GI 257196245
UniProt ID Q6ZPR5
mRNA ID NM_001164610
Length 794
RefSeq Status VALIDATED
MAFPHLQQPSFLLASLKADSINKPFAQRCQDLVKVIEDFPAKELHAVFPWLVESIFGSLDGVLVGWNLRCLQGRVNPVEYSTAMEFLDPSGPMMKLVYKLQAEDYNFDFPVSCLPGPVKASIQENVLPDSPLYHNKVQFPPTGGLGLNLALNPFEYYMFYFALSLISQKPMSMTLHVRTSDCAYFTLVDRYLSWFLPTEGSVPPPLCSSPGGSSPSPAPRTPAMPFASYGLHTSLLKRHISHQTSVNADPASHEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPHAKESFTPTEEHVLVVRLLLKHLHAFANSLKPDQASPSAHSHATSPLEEFKRAAVPRFVQQKLYVFLQHCFGHWPLDATFRAVLEMWLSYLQPWRYAPEKQAQGSDPQPRCVSEKWAPFIQENLLMYTKLFVSFLNRALRTDLVSPKNALMVFRVAKVFAQPNLAEMIQKGEQLFLEPELIIPHRQHRLFTVTTSFLSPWPPVVTDASFKVKSHVYSLEGQDCKYTPMFGPEIRTLVLRLAQLITQAKQTAKSISDQYVESPTGRSFLSWLTFGLTDTNSCYPANDLDEIGQDSIRKTDEYLEKALEYLRQIFRLSEAQLAQLTLALGSARDENGKQQLPDCIVGEEGLILTPLGRYQIINGLRRFEIEYQGDLELQPIRSYEITSLVRALFRLSSAINRRFAGQMAALCSRNDFLGSFCRYHLTEPALSNRHLLSPVGRRQVTNPARGPRLSLRFLGSYRTLLLLLMAFFVASLFCIGPLSCSLLLVLGYVLYAIAMTLLTERGKLHQL
sphingomyelin phosphodiesterase 4 isoform 4
Refseq ID NP_001158081
Protein GI 257196243
UniProt ID Q6ZPR5
mRNA ID NM_001164609
Length 807
RefSeq Status VALIDATED
MAFPHLQQPSFLLASLKADSINKPFAQRCQDLVKVIEDFPAKELHAVFPWLVESIFGSLDGVLVGWNLRCLQGRVNPVEYSTAMEFLDPSGPMMKLVYKLQAEDYNFDFPVSCLPGPVKASIQENVLPDSPLYHNKVQFPPTGGLGLNLALNPFEYYMFYFALSLISQKPMSMTLHVRTSDCAYFTLVDRYLSWFLPTEGSVPPPLCSSPGGSSPSPAPRTPAMPFASYGLHTSLLKRHISHQTSVNADPASHEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPHAKESFTPTEEHVLVVRLLLKHLHAFANSLKPDQASPSAHSHATSPLEEFKRAAVPRFVQQKLYVFLQHCFGHWPLDATFRAVLEMWLSYLQPWRYAPEKQAQGSDPQPRCVSEKCLAPWSPYQHRGLRAPFIQENLLMYTKLFVSFLNRALRTDLVSPKNALMVFRVAKVFAQPNLAEMIQKGEQLFLEPELIIPHRQHRLFTVTTSFLSPWPPVVTDASFKVKSHVYSLEGQDCKYTPMFGPEIRTLVLRLAQLITQAKQTAKSISDQYVESPTGRSFLSWLTFGLTDTNSCYPANDLDEIGQDSIRKTDEYLEKALEYLRQIFRLSEAQLAQLTLALGSARDENGKQQLPDCIVGEEGLILTPLGRYQIINGLRRFEIEYQGDLELQPIRSYEITSLVRALFRLSSAINRRFAGQMAALCSRNDFLGSFCRYHLTEPALSNRHLLSPVGRRQVTNPARGPRLSLRFLGSYRTLLLLLMAFFVASLFCIGPLSCSLLLVLGYVLYAIAMTLLTERGKLHQL

Gene Information

Entrez Gene ID
77626
Gene Name
sphingomyelin phosphodiesterase 4
Gene Symbol
Smpd4
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 ISS:HGNC C Golgi apparatus
GO:0005783 ISS:HGNC C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005802 ISS:HGNC C trans-Golgi network
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0050290 ISS:HGNC F sphingomyelin phosphodiesterase D activity
GO:0004767 IEA:UniProtKB-EC F sphingomyelin phosphodiesterase activity
GO:0071356 IEA:Ensembl P cellular response to tumor necrosis factor
GO:0046513 IEA:Ensembl P ceramide biosynthetic process
GO:0046475 IEA:Ensembl P glycerophospholipid catabolic process
GO:0006685 ISS:HGNC P sphingomyelin catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu01100 Metabolic pathways
mmu00600 Sphingolipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3DJ-11281 sphingomyelin metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5893995 Glycosphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR024129 Sphingomyelin phosphodiesterase 4

UniProt Annotations

Entry Information

Gene Name
sphingomyelin phosphodiesterase 4
Protein Entry
NSMA3_MOUSE
UniProt ID
Q6ZPR5
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q6ZPR5-1; Sequence=Displayed; Name=2; IsoId=Q6ZPR5-2; Sequence=VSP_022485; Name=3; IsoId=Q6ZPR5-3; Sequence=VSP_022485, VSP_022486; Note=No experimental confirmation available.; Name=4; IsoId=Q6ZPR5-4; Sequence=VSP_022485, VSP_022487; Note=No experimental confirmation available.; Name=5; IsoId=Q6ZPR5-5; Sequence=VSP_022484, VSP_022485; Note=No experimental confirmation available.;
Catalytic Activity Sphingomyelin + H(2)O = N-acylsphingosine + phosphocholine.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Enzyme Regulation Activated by phosphatidylserine and tumor necrosis factor (TNF). Inhibited by scyphostatin (By similarity). {ECO:0000250}.
Function Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. {ECO:0000250}.
Sequence Caution Sequence=BAC98164.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Subcellular Location Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane {ECO:0000250}; Single- pass membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006370 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
257196240 RefSeq NP_084221 823 sphingomyelin phosphodiesterase 4 isoform 1
257196247 RefSeq NP_001158083 793 sphingomyelin phosphodiesterase 4 isoform 2
257196245 RefSeq NP_001158082 794 sphingomyelin phosphodiesterase 4 isoform 3
257196243 RefSeq NP_001158081 807 sphingomyelin phosphodiesterase 4 isoform 4

Identical Sequences to LMP006370 proteins

Reference Database Accession Length Protein Name
GI:257196245 DBBJ BAC29229.1 794 unnamed protein product [Mus musculus]
GI:257196243 DBBJ BAE37694.1 807 unnamed protein product [Mus musculus]
GI:257196240 GenBank EDK97470.1 823 sphingomyelin phosphodiesterase 4, isoform CRA_a [Mus musculus]
GI:257196240 RefSeq XP_006522785.1 823 PREDICTED: sphingomyelin phosphodiesterase 4 isoform X3 [Mus musculus]
GI:257196240 SwissProt Q6ZPR5.2 823 RecName: Full=Sphingomyelin phosphodiesterase 4; AltName: Full=Neutral sphingomyelinase 3; Short=nSMase-3; Short=nSMase3; AltName: Full=Neutral sphingomyelinase III [Mus musculus]

Related Sequences to LMP006370 proteins

Reference Database Accession Length Protein Name
GI:257196240 DBBJ BAB31737.1 823 unnamed protein product [Mus musculus]
GI:257196247 DBBJ BAC27221.1 793 unnamed protein product [Mus musculus]
GI:257196245 DBBJ BAC27512.1 794 unnamed protein product [Mus musculus]
GI:257196247 DBBJ BAC29229.1 794 unnamed protein product [Mus musculus]
GI:257196243 DBBJ BAC29229.1 794 unnamed protein product [Mus musculus]
GI:257196240 DBBJ BAC98164.1 857 mKIAA1418 protein, partial [Mus musculus]
GI:257196245 GenBank AAH26767.1 794 Smpd4 protein [Mus musculus]
GI:257196245 GenBank EDK97471.1 833 sphingomyelin phosphodiesterase 4, isoform CRA_b, partial [Mus musculus]
GI:257196243 GenBank EDK97471.1 833 sphingomyelin phosphodiesterase 4, isoform CRA_b, partial [Mus musculus]
GI:257196247 GenBank EDK97471.1 833 sphingomyelin phosphodiesterase 4, isoform CRA_b, partial [Mus musculus]
GI:257196247 GenBank EDK97472.1 835 sphingomyelin phosphodiesterase 4, isoform CRA_c, partial [Mus musculus]
GI:257196243 GenBank EDK97472.1 835 sphingomyelin phosphodiesterase 4, isoform CRA_c, partial [Mus musculus]
GI:257196245 GenBank EDK97472.1 835 sphingomyelin phosphodiesterase 4, isoform CRA_c, partial [Mus musculus]
GI:257196240 GenBank EDL77898.1 823 rCG36774 [Rattus norvegicus]
GI:257196247 RefSeq NP_001158082.1 794 sphingomyelin phosphodiesterase 4 isoform 3 [Mus musculus]
GI:257196243 RefSeq NP_001158082.1 794 sphingomyelin phosphodiesterase 4 isoform 3 [Mus musculus]
GI:257196245 RefSeq NP_001158083.1 793 sphingomyelin phosphodiesterase 4 isoform 2 [Mus musculus]
GI:257196243 RefSeq NP_001158083.1 793 sphingomyelin phosphodiesterase 4 isoform 2 [Mus musculus]
GI:257196240 RefSeq XP_006522783.1 853 PREDICTED: sphingomyelin phosphodiesterase 4 isoform X1 [Mus musculus]
GI:257196245 RefSeq XP_006522784.1 824 PREDICTED: sphingomyelin phosphodiesterase 4 isoform X2 [Mus musculus]
GI:257196247 RefSeq XP_006522784.1 824 PREDICTED: sphingomyelin phosphodiesterase 4 isoform X2 [Mus musculus]
GI:257196243 RefSeq XP_006522784.1 824 PREDICTED: sphingomyelin phosphodiesterase 4 isoform X2 [Mus musculus]
GI:257196240 RefSeq XP_008767100.1 853 PREDICTED: sphingomyelin phosphodiesterase 4 isoform X1 [Rattus norvegicus]
GI:257196240 RefSeq NP_001161278.2 823 sphingomyelin phosphodiesterase 4 [Rattus norvegicus]