Gene/Proteome Database (LMPD)

LMPD ID
LMP006373
Gene ID
54150
Species
Mus musculus (Mouse)
Gene Name
retinol dehydrogenase 7
Gene Symbol
Rdh7
Synonyms
AI194929; CRAD2
Alternate Names
retinol dehydrogenase 7; CRAD-2; cis-retinol/androgen dehydrogenase type 2; cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme 2
Chromosome
10
Map Location
10 D3|10
EC Number
1.1.1.105

Proteins

retinol dehydrogenase 7 precursor
Refseq ID NP_001144221
Protein GI 226510365
UniProt ID O88451
mRNA ID NM_001150749
Length 316
RefSeq Status VALIDATED
MWLYLVALVGLWTLLRFFRERQVVSHLQDKYVFITGCDSGFGNLLARQLDRRGMRVLAACLTEKGAEQLRNKTSDRLETVILDVTKTESIVAATQWVKERVGNRGLWGLVNNAGICVFAINEWLKKEDFANILDVNLLGMIEVTLSMLPLVRKARGRVVNISSSMGRVSLCGGGYCISKYGVEAFSDSLRREISYFGVKVAIIEPGGFRTNVSNYERLSHSIEKLWDQTSSEVKEVYDKNFLDSYIKAIQSLTDTCSDDLSVVTDCMEHALTACHPRTRYSAGWDAKLFYLPLSYMPTFLVDAMLYWSSVKPAQAL
retinol dehydrogenase 7 precursor
Refseq ID NP_059501
Protein GI 8567342
UniProt ID O88451
mRNA ID NM_017473
Length 316
RefSeq Status VALIDATED
Protein sequence is identical to GI:226510365 (mRNA isoform)
sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2095 peptide sequence: MWLYLVALVGLWTLLRF sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2095 peptide sequence: MWLYLVALVGLWTLLRF

Gene Information

Entrez Gene ID
54150
Gene Name
retinol dehydrogenase 7
Gene Symbol
Rdh7
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0003824 ISS:MGI F catalytic activity
GO:0004745 IEA:UniProtKB-EC F retinol dehydrogenase activity
GO:0042572 IEA:UniProtKB-UniPathway P retinol metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR020904 Short-chain dehydrogenase/reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
retinol dehydrogenase 7
Protein Entry
RDH7_MOUSE
UniProt ID
O88451
Species
Mouse

Comments

Comment Type Description
Catalytic Activity All-trans-retinol-[cellular-retinol-binding- protein] + NAD(+) = all-trans-retinal-[cellular-retinol-binding- protein] + NADH.
Function Acts on androgens and retinols, i.e. has steroid 3- alpha- and 17-beta-dehydrogenase and cis/trans-retinol catalytic activities. {ECO:0000269|PubMed:9651397}.
Pathway Cofactor metabolism; retinol metabolism.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular Location Microsome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Tissue Specificity Highly expressed in liver. Also expressed in lung, eye, kidney, and brain. {ECO:0000269|PubMed:9651397}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006373 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
226510365 RefSeq NP_001144221 316 retinol dehydrogenase 7 precursor

Identical Sequences to LMP006373 proteins

Reference Database Accession Length Protein Name
GI:226510365 DBBJ BAB03719.1 316 cis-retinol/androgen dehydrogenase type 2 [Mus musculus]
GI:226510365 GenBank AAH24603.1 316 Retinol dehydrogenase 7 [Mus musculus]
GI:226510365 GenBank AAH92255.1 316 Retinol dehydrogenase 7 [Mus musculus]
GI:226510365 GenBank AAH93514.1 316 Retinol dehydrogenase 7 [Mus musculus]
GI:226510365 GenBank EDL24530.1 316 mCG17033 [Mus musculus]
GI:226510365 SwissProt O88451.1 316 RecName: Full=Retinol dehydrogenase 7; AltName: Full=Cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme 2; AltName: Full=Cis-retinol/androgen dehydrogenase type 2; Short=CRAD-2 [Mus musculus]

Related Sequences to LMP006373 proteins

Reference Database Accession Length Protein Name
GI:226510365 GenBank AAB07997.1 317 retinol dehydrogenase type I [Rattus norvegicus]
GI:226510365 GenBank AAE57309.1 317 Sequence 5 from patent US 6171837
GI:226510365 GenBank AAE80112.1 316 Sequence 36 from patent US 6280997
GI:226510365 GenBank AAM60357.1 316 Sequence 36 from patent US 6399344
GI:226510365 GenBank ABP13398.1 317 Sequence 5 from patent US 7186534
GI:226510365 SwissProt P50169.1 317 RecName: Full=Retinol dehydrogenase 3; AltName: Full=Retinol dehydrogenase type I; Short=RODH I [Rattus norvegicus]