Gene/Proteome Database (LMPD)

LMPD ID
LMP006399
Gene ID
54884
Species
Homo sapiens (Human)
Gene Name
retinol saturase (all-trans-retinol 13,14-reductase)
Gene Symbol
RETSAT
Synonyms
-
Alternate Names
all-trans-retinol 13,14-reductase; all-trans-13,14-dihydroretinol saturase; PPAR-alpha-regulated and starvation-induced gene protein
Chromosome
2
Map Location
2p11.2
EC Number
1.3.99.23

Proteins

all-trans-retinol 13,14-reductase precursor
Refseq ID NP_060220
Protein GI 203098013
UniProt ID Q6NUM9
mRNA ID NM_017750
Length 610
RefSeq Status VALIDATED
MWLPLVLLLAVLLLAVLCKVYLGLFSGSSPNPFSEDVKRPPAPLVTDKEARKKVLKQAFSANQVPEKLDVVVIGSGFGGLAAAAILAKAGKRVLVLEQHTKAGGCCHTFGKNGLEFDTGIHYIGRMEEGSIGRFILDQITEGQLDWAPLSSPFDIMVLEGPNGRKEYPMYSGEKAYIQGLKEKFPQEEAIIDKYIKLVKVVSSGAPHAILLKFLPLPVVQLLDRCGLLTRFSPFLQASTQSLAEVLQQLGASSELQAVLSYIFPTYGVTPNHSAFSMHALLVNHYMKGGFYPRGGSSEIAFHTIPVIQRAGGAVLTKATVQSVLLDSAGKACGVSVKKGHELVNIYCPIVVSNAGLFNTYEHLLPGNARCLPGVKQQLGTVRPGLGMTSVFICLRGTKEDLHLPSTNYYVYYDTDMDQAMERYVSMPREEAAEHIPLLFFAFPSAKDPTWEDRFPGRSTMIMLIPTAYEWFEEWQAELKGKRGSDYETFKNSFVEASMSVVLKLFPQLEGKVESVTAGSPLTNQFYLAAPRGACYGADHDLGRLHPCVMASLRAQSPIPNLYLTGQDIFTCGLVGALQGALLCSSAILKRNLYSDLKNLDSRIRAQKKKN
sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1994 peptide sequence: MWLPLVLLLAVLLLAVLC mat_peptide: 19..610 product: All-trans-retinol 13,14-reductase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q6NUM9.2) calculated_mol_wt: 64844 peptide sequence: KVYLGLFSGSSPNPFSEDVKRPPAPLVTDKEARKKVLKQAFSANQVPEKLDVVVIGSGFGGLAAAAILAKAGKRVLVLEQHTKAGGCCHTFGKNGLEFDTGIHYIGRMEEGSIGRFILDQITEGQLDWAPLSSPFDIMVLEGPNGRKEYPMYSGEKAYIQGLKEKFPQEEAIIDKYIKLVKVVSSGAPHAILLKFLPLPVVQLLDRCGLLTRFSPFLQASTQSLAEVLQQLGASSELQAVLSYIFPTYGVTPNHSAFSMHALLVNHYMKGGFYPRGGSSEIAFHTIPVIQRAGGAVLTKATVQSVLLDSAGKACGVSVKKGHELVNIYCPIVVSNAGLFNTYEHLLPGNARCLPGVKQQLGTVRPGLGMTSVFICLRGTKEDLHLPSTNYYVYYDTDMDQAMERYVSMPREEAAEHIPLLFFAFPSAKDPTWEDRFPGRSTMIMLIPTAYEWFEEWQAELKGKRGSDYETFKNSFVEASMSVVLKLFPQLEGKVESVTAGSPLTNQFYLAAPRGACYGADHDLGRLHPCVMASLRAQSPIPNLYLTGQDIFTCGLVGALQGALLCSSAILKRNLYSDLKNLDSRIRAQKKKN

Gene Information

Entrez Gene ID
54884
Gene Name
retinol saturase (all-trans-retinol 13,14-reductase)
Gene Symbol
RETSAT
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 ISS:HGNC C endoplasmic reticulum membrane
GO:0016020 IDA:UniProtKB C membrane
GO:0031965 ISS:HGNC C nuclear membrane
GO:0005640 ISS:HGNC C nuclear outer membrane
GO:0051786 ISS:HGNC F all-trans-retinol 13,14-reductase activity
GO:0016491 ISS:HGNC F oxidoreductase activity
GO:0055114 ISS:HGNC P oxidation-reduction process
GO:0042572 ISS:HGNC P retinol metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00830 Retinol metabolism
ko00830 Retinol metabolism

Domain Information

InterPro Annotations

Accession Description

UniProt Annotations

Entry Information

Gene Name
retinol saturase (all-trans-retinol 13,14-reductase)
Protein Entry
RETST_HUMAN
UniProt ID
Q6NUM9
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NUM9-1; Sequence=Displayed; Name=2; IsoId=Q6NUM9-2; Sequence=VSP_017410, VSP_017411; Note=No experimental confirmation available.;
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NUM9-1; Sequence=Displayed; Name=2; IsoId=Q6NUM9-2; Sequence=VSP_017410, VSP_017411; Note=No experimental confirmation available.;
Catalytic Activity All-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor.
Cofactor Name=NAD(+); Xref=ChEBI
Cofactor Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250}; Name=NADP(+); Xref=ChEBI:CHEBI:58349; Evidence={ECO:0000250}; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
Function Retinol saturase carrying out the saturation of the 13- 14 double bond of all-trans-retinol to produce all-trans-13,14- dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A (By similarity).
Function Retinol saturase carrying out the saturation of the 13- 14 double bond of all-trans-retinol to produce all-trans-13,14- dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A (By similarity). {ECO:0000250}.
Sequence Caution Sequence=AAH11418.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=BAA91069.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
Sequence Caution Sequence=AAH11418.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91069.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily.
Similarity Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006399 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
203098013 RefSeq NP_060220 610 all-trans-retinol 13,14-reductase precursor

Identical Sequences to LMP006399 proteins

Reference Database Accession Length Protein Name
GI:203098013 GenBank ADI53924.1 610 Sequence 92 from patent US 7423120
GI:203098013 GenBank ADL73121.1 610 Sequence 92 from patent US 7696319
GI:203098013 GenBank ADL91291.1 610 Sequence 92 from patent US 7709602
GI:203098013 GenBank ADL91601.1 610 Sequence 92 from patent US 7709603
GI:203098013 GenBank ADL97682.1 610 Sequence 92 from patent US 7718770
GI:203098013 GenBank AEU55129.1 610 Sequence 92 from patent US 8063186

Related Sequences to LMP006399 proteins

Reference Database Accession Length Protein Name
GI:203098013 DBBJ BAC11505.1 610 unnamed protein product [Homo sapiens]
GI:203098013 EMBL CAF86585.1 610 unnamed protein product [Homo sapiens]
GI:203098013 GenBank AAH68517.1 610 Retinol saturase (all-trans-retinol 13,14-reductase) [Homo sapiens]
GI:203098013 GenBank JAA16093.1 610 retinol saturase (all-trans-retinol 13,14-reductase) [Pan troglodytes]
GI:203098013 GenBank JAA24793.1 610 retinol saturase (all-trans-retinol 13,14-reductase) [Pan troglodytes]
GI:203098013 GenBank JAA33466.1 610 retinol saturase (all-trans-retinol 13,14-reductase) [Pan troglodytes]