Gene/Proteome Database (LMPD)

LMPD ID
LMP006407
Gene ID
100678
Species
Mus musculus (Mouse)
Gene Name
phosphoserine phosphatase
Gene Symbol
Psph
Synonyms
AI480570; PSP; PSPase
Alternate Names
phosphoserine phosphatase; O-phosphoserine phosphohydrolase
Chromosome
5
Map Location
5 G1.3|5
EC Number
3.1.3.3

Proteins

phosphoserine phosphatase
Refseq ID NP_598661
Protein GI 19527116
UniProt ID Q99LS3
mRNA ID NM_133900
Length 225
RefSeq Status VALIDATED
MVSHSELRKLFCSADAVCFDVDSTVIREEGIDELAKFCGVEAAVSEMTRRAMGGALPFKDALTQRLALIQPSRDQVQRLLAEHPPHLTPGIRELVSRLQERNVQVFLISGGFRSIVEHVAAKLNIPTTNVFANRLKFYFNGEYAGFDEMQPTAESGGKGKVIRFLKEKFHFKKIIMIGDGATDMEACPPADAFIGFGGNVIRQQVKDNAKWYITDFVELLGELEE

Gene Information

Entrez Gene ID
100678
Gene Name
phosphoserine phosphatase
Gene Symbol
Psph
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IBA:RefGenome C cytoplasm
GO:0043005 IEA:Ensembl C neuron projection
GO:0005509 ISS:UniProtKB F calcium ion binding
GO:0000287 ISS:UniProtKB F magnesium ion binding
GO:0004647 ISS:UniProtKB F phosphoserine phosphatase activity
GO:0016311 IBA:RefGenome P dephosphorylation
GO:0006564 IBA:RefGenome P L-serine biosynthetic process
GO:0006563 ISS:UniProtKB P L-serine metabolic process
GO:0009612 IEA:Ensembl P response to mechanical stimulus
GO:0031667 IEA:Ensembl P response to nutrient levels
GO:0033574 IEA:Ensembl P response to testosterone

KEGG Pathway Links

KEGG Pathway ID Description
mmu01230 Biosynthesis of amino acids
mmu01200 Carbon metabolism
mmu00260 Glycine, serine and threonine metabolism

Domain Information

InterPro Annotations

Accession Description
IPR023214 HAD-like domain
IPR006383 HAD-superfamily hydrolase, subfamily IB, PSPase-like
IPR023190 Phosphoserine phosphatase, domain 2
IPR004469 Phosphoserine phosphatase SerB

UniProt Annotations

Entry Information

Gene Name
phosphoserine phosphatase
Protein Entry
SERB_MOUSE
UniProt ID
Q99LS3
Species
Mouse

Comments

Comment Type Description
Catalytic Activity O-phospho-L(or D)-serine + H(2)O = L(or D)- serine + phosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250};
Function Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (By similarity). {ECO:0000250}.
Pathway Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.
Similarity Belongs to the SerB family. {ECO:0000305}.
Subunit Homodimer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006407 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
19527116 RefSeq NP_598661 225 phosphoserine phosphatase

Identical Sequences to LMP006407 proteins

Reference Database Accession Length Protein Name
GI:19527116 DBBJ BAC40622.1 225 unnamed protein product [Mus musculus]
GI:19527116 DBBJ BAE40030.1 225 unnamed protein product [Mus musculus]
GI:19527116 GenBank EDL19499.1 225 phosphoserine phosphatase, isoform CRA_a [Mus musculus]
GI:19527116 GenBank EDL19500.1 225 phosphoserine phosphatase, isoform CRA_a [Mus musculus]
GI:19527116 RefSeq XP_006504337.1 225 PREDICTED: phosphoserine phosphatase isoform X1 [Mus musculus]
GI:19527116 SwissProt Q99LS3.1 225 RecName: Full=Phosphoserine phosphatase; Short=PSP; Short=PSPase; AltName: Full=O-phosphoserine phosphohydrolase [Mus musculus]

Related Sequences to LMP006407 proteins

Reference Database Accession Length Protein Name
GI:19527116 GenBank AAH88310.1 225 Phosphoserine phosphatase [Rattus norvegicus]
GI:19527116 GenBank EDM13488.1 225 phosphoserine phosphatase, isoform CRA_a [Rattus norvegicus]
GI:19527116 GenBank EDM13489.1 225 phosphoserine phosphatase, isoform CRA_a [Rattus norvegicus]
GI:19527116 GenBank EDM13491.1 225 phosphoserine phosphatase, isoform CRA_a [Rattus norvegicus]
GI:19527116 RefSeq NP_001009679.1 225 phosphoserine phosphatase [Rattus norvegicus]
GI:19527116 SwissProt Q5M819.1 225 RecName: Full=Phosphoserine phosphatase; Short=PSP; Short=PSPase; AltName: Full=O-phosphoserine phosphohydrolase [Rattus norvegicus]