Gene/Proteome Database (LMPD)

LMPD ID
LMP006491
Gene ID
3301
Species
Homo sapiens (Human)
Gene Name
DnaJ (Hsp40) homolog, subfamily A, member 1
Gene Symbol
DNAJA1
Synonyms
DJ-2; DjA1; HDJ2; HSDJ; HSJ2; HSPF4; NEDD7; hDJ-2
Alternate Names
dnaJ homolog subfamily A member 1; HSJ-2; human DnaJ protein 2; heat shock protein J2; dnaJ protein homolog 2; heat shock 40 kDa protein 4; heat shock protein, DNAJ-like 2; neural precursor cell expressed, developmentally down-regulated 7
Chromosome
9
Map Location
9p13.3

Proteins

dnaJ homolog subfamily A member 1
Refseq ID NP_001530
Protein GI 4504511
UniProt ID P31689
mRNA ID NM_001539
Length 397
RefSeq Status VALIDATED
MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLSDAKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQCQTS
mat_peptide: 1..394 product: DnaJ homolog subfamily A member 1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P31689.2) calculated_mol_wt: 44552 peptide sequence: MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLSDAKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQC

Gene Information

Entrez Gene ID
3301
Gene Name
DnaJ (Hsp40) homolog, subfamily A, member 1
Gene Symbol
DNAJA1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0098554 TAS:ParkinsonsUK-UCL C cytoplasmic side of endoplasmic reticulum membrane
GO:0005829 IDA:UniProt C cytosol
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0016020 IDA:UniProtKB C membrane
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0005524 IEA:InterPro F ATP binding
GO:0001664 IPI:ParkinsonsUK-UCL F G-protein coupled receptor binding
GO:0030544 IDA:UniProtKB F Hsp70 protein binding
GO:0051087 IDA:UniProtKB F chaperone binding
GO:0050750 IDA:MGI F low-density lipoprotein particle receptor binding
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0031625 IPI:ParkinsonsUK-UCL F ubiquitin protein ligase binding
GO:0042769 IEA:Ensembl P DNA damage response, detection of DNA damage
GO:0030521 IEA:Ensembl P androgen receptor signaling pathway
GO:0043508 IMP:UniProtKB P negative regulation of JUN kinase activity
GO:0043066 IMP:UniProtKB P negative regulation of apoptotic process
GO:0031397 IDA:ParkinsonsUK-UCL P negative regulation of protein ubiquitination
GO:0043065 IMP:UniProtKB P positive regulation of apoptotic process
GO:0006457 TAS:ProtInc P protein folding
GO:0070585 IMP:UniProtKB P protein localization to mitochondrion
GO:0051223 IDA:UniProtKB P regulation of protein transport
GO:0009408 IEA:InterPro P response to heat
GO:0006986 TAS:ProtInc P response to unfolded protein
GO:0030317 IEA:Ensembl P sperm motility
GO:0007283 IEA:Ensembl P spermatogenesis

KEGG Pathway Links

KEGG Pathway ID Description
hsa04141 Protein processing in endoplasmic reticulum
ko04141 Protein processing in endoplasmic reticulum

Domain Information

InterPro Annotations

Accession Description
IPR012724 Chaperone DnaJ
IPR002939 Chaperone DnaJ, C-terminal
IPR018253 DnaJ domain, conserved site
IPR001623 DnaJ_domain
IPR008971 HSP40/DnaJ peptide-binding
IPR001305 Heat shock protein DnaJ, cysteine-rich domain

UniProt Annotations

Entry Information

Gene Name
DnaJ (Hsp40) homolog, subfamily A, member 1
Protein Entry
DNJA1_HUMAN
UniProt ID
P31689
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P31689-1; Sequence=Displayed; Name=2; Synonyms=nDnaJA1; IsoId=P31689-2; Sequence=VSP_046566;
Function Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co- chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). {ECO
Induction Up-regulated by heat shock.
Interaction Q9GZX7:AICDA; NbExp=6; IntAct=EBI-347834, EBI-3834328;
Similarity Contains 1 CR-type zinc finger.
Similarity Contains 1 J domain.
Subcellular Location Membrane ; Lipid-anchor . Cytoplasm {ECO
Subunit Identified in a complex with HSPA1B and BAX.
Tissue Specificity Ubiquitous. Isoform 2 is highly expressed in testis and lung, but detected at low levels in thymus, prostate, colon and liver. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP006491 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4504511 RefSeq NP_001530 397 dnaJ homolog subfamily A member 1

Identical Sequences to LMP006491 proteins

Reference Database Accession Length Protein Name
GI:4504511 RefSeq XP_008693331.1 397 PREDICTED: dnaJ homolog subfamily A member 1 [Ursus maritimus]
GI:4504511 RefSeq XP_008996448.1 397 PREDICTED: dnaJ homolog subfamily A member 1 [Callithrix jacchus]
GI:4504511 RefSeq XP_008996458.1 397 PREDICTED: dnaJ homolog subfamily A member 1 [Callithrix jacchus]
GI:4504511 RefSeq XP_008996461.1 397 PREDICTED: dnaJ homolog subfamily A member 1 [Callithrix jacchus]
GI:4504511 RefSeq XP_009186908.1 397 PREDICTED: dnaJ homolog subfamily A member 1 [Papio anubis]
GI:4504511 RefSeq XP_010376844.1 397 PREDICTED: dnaJ homolog subfamily A member 1 [Rhinopithecus roxellana]

Related Sequences to LMP006491 proteins

Reference Database Accession Length Protein Name
GI:4504511 GenBank AAK81721.1 397 DnaJ-like protein [Chlorocebus aethiops]
GI:4504511 GenBank AAP88901.1 398 DnaJ (Hsp40) homolog, subfamily A, member 1, partial [synthetic construct]
GI:4504511 GenBank AAX43661.1 398 DnaJ-like subfamily A member 1, partial [synthetic construct]
GI:4504511 RefSeq XP_004485318.1 415 PREDICTED: LOW QUALITY PROTEIN: DnaJ (Hsp40) homolog, subfamily A, member 1 [Dasypus novemcinctus]
GI:4504511 RefSeq XP_005903076.1 397 PREDICTED: dnaJ homolog subfamily A member 1 [Bos mutus]
GI:4504511 SwissProt Q95JF4.1 397 RecName: Full=DnaJ homolog subfamily A member 1; AltName: Full=DnaJ protein homolog 2; Short=DJ-2; AltName: Full=Mydj2; Flags: Precursor [Chlorocebus aethiops]