Gene/Proteome Database (LMPD)
LMPD ID
LMP006518
Gene ID
Species
Mus musculus (Mouse)
Gene Name
Rab geranylgeranyl transferase, a subunit
Gene Symbol
Synonyms
gm
Alternate Names
geranylgeranyl transferase type-2 subunit alpha; gunmetal; rab GGTase alpha; rab GG transferase alpha; rab geranylgeranyltransferase subunit alpha; rab geranyl-geranyltransferase subunit alpha; geranylgeranyl transferase type II subunit alpha
Chromosome
14
Map Location
14 C3|14 28.19 cM
EC Number
2.5.1.60
Proteins
| geranylgeranyl transferase type-2 subunit alpha | |
|---|---|
| Refseq ID | NP_062392 |
| Protein GI | 9507023 |
| UniProt ID | Q9JHK4 |
| mRNA ID | NM_019519 |
| Length | 567 |
| RefSeq Status | PROVISIONAL |
| MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKREAGELDESVLELTSQILGANPDFATLWNCRREVLQQLETQKSPEELAALVKAELGFLESCLRVNPKSYGTWHHRCWLLSRLPEPNWARELELCARFLEADERNFHCWDYRRFVAAQAAVAPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPENVLLRELELVQNAFFTDPNDQSAWFYHRWLLGRAEPHDVLCCLHVSREEACLSVCFSRPLIVGSKMGTLLLTVDEAPLSVEWRTPDGRNRPSHVWLCDLPAASLNDHLPQHTFRVIWTGSDTQKECVLLKGHQECWCRDSATDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLEYFSTLKAVDPMRAAYLDDLRSKFLVENSVLKMEYADVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQASDNVLENLDGVANLPRLRELLLCNNRLQQSAALQTLASCPRLVFLNLQGNSLCQEEGIRERLAEMLPSVSSILT | |
Gene Information
Entrez Gene ID
Gene Name
Rab geranylgeranyl transferase, a subunit
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005968 | ISS:UniProtKB | C | Rab-protein geranylgeranyltransferase complex |
| GO:0004663 | IMP:MGI | F | Rab geranylgeranyltransferase activity |
| GO:0017137 | ISS:UniProtKB | F | Rab GTPase binding |
| GO:0008270 | IEA:InterPro | F | zinc ion binding |
| GO:0018344 | IMP:MGI | P | protein geranylgeranylation |
Domain Information
UniProt Annotations
Entry Information
Gene Name
Rab geranylgeranyl transferase, a subunit
Protein Entry
PGTA_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9JHK4-1; Sequence=Displayed; Name=2; IsoId=Q9JHK4-2; Sequence=VSP_009113, VSP_009114; |
| Catalytic Activity | Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. |
| Disease | Note=Defects in Rabggta are the cause of the gunmetal (gm) phenotype. Mice homozygous for gm have prolonged bleeding, thrombocytopenia and reduced platelet alpha- and delta-granule contents. {ECO:0000269|PubMed:10737774}. |
| Enzyme Regulation | The enzymatic reaction requires the aid of a Rab escort protein (also called component A), such as CHM. {ECO:0000250}. |
| Function | Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. {ECO:0000269|PubMed:10737774}. |
| Similarity | Belongs to the protein prenyltransferase subunit alpha family. {ECO:0000305}. |
| Similarity | Contains 5 LRR (leucine-rich) repeats. {ECO:0000305}. |
| Similarity | Contains 6 PFTA repeats. {ECO:0000255|PROSITE- ProRule:PRU00488}. |
| Subunit | Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp (By similarity). {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006518 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 9507023 | RefSeq | NP_062392 | 567 | geranylgeranyl transferase type-2 subunit alpha |
Identical Sequences to LMP006518 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:9507023 | DBBJ | BAB22240.1 | 567 | unnamed protein product [Mus musculus] |
| GI:9507023 | GenBank | EDL36251.1 | 567 | Rab geranylgeranyl transferase, a subunit, isoform CRA_f [Mus musculus] |
| GI:9507023 | GenBank | EDL36252.1 | 567 | Rab geranylgeranyl transferase, a subunit, isoform CRA_f [Mus musculus] |
| GI:9507023 | RefSeq | XP_006519357.1 | 567 | PREDICTED: geranylgeranyl transferase type-2 subunit alpha isoform X1 [Mus musculus] |
| GI:9507023 | RefSeq | XP_006519358.1 | 567 | PREDICTED: geranylgeranyl transferase type-2 subunit alpha isoform X2 [Mus musculus] |
| GI:9507023 | SwissProt | Q9JHK4.1 | 567 | RecName: Full=Geranylgeranyl transferase type-2 subunit alpha; AltName: Full=Geranylgeranyl transferase type II subunit alpha; AltName: Full=Rab geranyl-geranyltransferase subunit alpha; Short=Rab GG transferase alpha; Short=Rab GGTase alpha; AltName: Full=Rab geranylgeranyltransferase subunit alpha [Mus musculus] |
Related Sequences to LMP006518 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:9507023 | DBBJ | BAE27529.1 | 567 | unnamed protein product [Mus musculus] |
| GI:9507023 | GenBank | AAH86547.1 | 567 | Rab geranylgeranyltransferase, alpha subunit [Rattus norvegicus] |
| GI:9507023 | GenBank | EDL36246.1 | 570 | Rab geranylgeranyl transferase, a subunit, isoform CRA_a, partial [Mus musculus] |
| GI:9507023 | GenBank | EDL36247.1 | 607 | Rab geranylgeranyl transferase, a subunit, isoform CRA_b, partial [Mus musculus] |
| GI:9507023 | GenBank | EDM14271.1 | 567 | Rab geranylgeranyl transferase, a subunit, isoform CRA_a [Rattus norvegicus] |
| GI:9507023 | GenBank | EDM14272.1 | 567 | Rab geranylgeranyl transferase, a subunit, isoform CRA_a [Rattus norvegicus] |