Gene/Proteome Database (LMPD)

LMPD ID
LMP006556
Gene ID
230101
Species
Mus musculus (Mouse)
Gene Name
glucosidase beta 2
Gene Symbol
Gba2
Synonyms
F630034E04
Alternate Names
non-lysosomal glucosylceramidase; NLGase; bile acid; beta-glucosidase 2; glucosylceramidase 2; beta-glucocerebrosidase 2; glucosidase, beta (bile acid) 2
Chromosome
4
Map Location
4 B1|4
EC Number
3.2.1.45

Proteins

non-lysosomal glucosylceramidase
Refseq ID NP_766280
Protein GI 240120073
UniProt ID Q69ZF3
mRNA ID NM_172692
Length 918
RefSeq Status VALIDATED
MVTCVPASEQVGCAERDSQVYCEDTGGTEAVRVTDCGSPEDSGPQDEPSYCNSEDSGQLMASYEGKARGYQVPPFGWRICLAHEFAEKRRPFQANNISLSNLVKHLGMGLRYLKWWYRKTHVEKKTPFIDMLNSLPLRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMYQHQTVIADQFIVCLRRDGRTVYQQVLSLELPNVLRSWNWGLCGYFAFYHALYPRAWTVYQLPGQNVTLTCRQVTPILPHDYQDSSLPVGVFVWDVENEGDETLDVSITFSMRNGLGGEDDAAGSLWNEPFRLEQGGTTVQGLLLHHPTPPNPYTMAVAARCTADTTVTHTTAFDPNGTGQQVWQDLLQDGQLDSPAGQSTPTQKGEGIAGAVCVSSKLLPRSRCCLEFSLAWDMPKIMFGAKSQVHYRRYTRFFGSDGDVAPALSHYALCHYADWEDRISAWQNPVLDDRTLPAWYKSALFNELYFLADGGTVWLEVPADSLPEGLGGSMRQLRSTLQDYGRFGYLEGQEYRMYNTYDVHFYASFALVMLWPKLELSLQYDMALATLKEDLTRRRYLMSGVVAPVKRRNVIPHDIGDPDDEPWLRVNAYLIHDTADWKDLNLKFVLQIYRDYYLTGDQGFLEDMWPVCLAVMESEMKFDKDQDGLIENGGYADQTYDAWVTTGPSAYCGGLWLAAVAVMVQMAVLCGAQDVQERFASILCRGREAYERLLWNGRYYNYDSSSHPQSRSIMSDQCAGQWFLRACGLGEGDTEVFPTLHVVRALQTIFELNVQAFAGGAMGAVNGMHPHGVPDRSSVQSDEVWVGVVYGLAATMIQEGLTWEGFRTAEGCYRTVWERLGLAFQTPEAYCQQQVFRSLAYMRPLSIWAMQLALQQQQHKKSRRPSVTQGTGLSTQPECGPKRSLANLNSE

Gene Information

Entrez Gene ID
230101
Gene Name
glucosidase beta 2
Gene Symbol
Gba2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016021 IEA:InterPro C integral component of membrane
GO:0008422 ISS:UniProtKB F beta-glucosidase activity
GO:0004348 IEA:UniProtKB-EC F glucosylceramidase activity
GO:0021954 ISS:UniProtKB P central nervous system neuron development
GO:0006680 IEA:InterPro P glucosylceramide catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu01100 Metabolic pathways
mmu00511 Other glycan degradation
mmu00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5893995 Glycosphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR014551 Beta-glucosidase, GBA2 type
IPR024462 Beta-glucosidase, GBA2 type, N-terminal
IPR006775 Glucosylceramidase
IPR008928 Six-hairpin glycosidase-like

UniProt Annotations

Entry Information

Gene Name
glucosidase beta 2
Protein Entry
GBA2_MOUSE
UniProt ID
Q69ZF3
Species
Mouse

Comments

Comment Type Description
Catalytic Activity D-glucosyl-N-acylsphingosine + H(2)O = D- glucose + N-acylsphingosine. {ECO:0000269|PubMed:23250757}.
Disruption Phenotype Mice have a normal bile acid metabolism but males exhibit impaired fertility due to glucosylceramides accumulation. {ECO:0000269|PubMed:17080196}.
Enzyme Regulation Enzymatic activity is dependent on membrane association and requires the presence of lipids. {ECO:0000269|PubMed:23250757}.
Function Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo. Plays a role in central nevous system development (By similarity). Required for proper formation of motor neuron axons (By similarity). {ECO:0000250}.
Sequence Caution Sequence=BAD32491.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the non-lysosomal glucosylceramidase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:23250757}; Peripheral membrane protein {ECO:0000269|PubMed:23250757}; Cytoplasmic side {ECO:0000269|PubMed:23250757}. Golgi apparatus membrane {ECO:0000269|PubMed:23250757}; Peripheral membrane protein {ECO:0000269|PubMed:23250757}; Cytoplasmic side {ECO:0000269|PubMed:23250757}. Note=Not localized to lipid rafts. {ECO:0000250}.
Tissue Specificity Widely expressed at low level. Highly expressed in testis and brain. {ECO:0000269|PubMed:17080196, ECO:0000269|PubMed:23250757}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006556 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
240120073 RefSeq NP_766280 918 non-lysosomal glucosylceramidase

Identical Sequences to LMP006556 proteins

Reference Database Accession Length Protein Name
GI:240120073 GenBank AAH56935.1 918 Glucosidase beta 2 [Mus musculus]
GI:240120073 SwissProt Q69ZF3.2 918 RecName: Full=Non-lysosomal glucosylceramidase; Short=NLGase; AltName: Full=Beta-glucocerebrosidase 2; Short=Beta-glucosidase 2; AltName: Full=Glucosylceramidase 2 [Mus musculus]

Related Sequences to LMP006556 proteins

Reference Database Accession Length Protein Name
GI:240120073 DBBJ BAC40785.1 918 unnamed protein product [Mus musculus]
GI:240120073 DBBJ BAD32491.1 940 mKIAA1605 protein, partial [Mus musculus]
GI:240120073 GenBank EDL02461.1 918 glucosidase beta 2, isoform CRA_a [Mus musculus]
GI:240120073 GenBank EDL98757.1 904 glucosidase beta 2 [Rattus norvegicus]
GI:240120073 RefSeq NP_001013109.2 904 non-lysosomal glucosylceramidase [Rattus norvegicus]
GI:240120073 SwissProt Q5M868.2 912 RecName: Full=Non-lysosomal glucosylceramidase; Short=NLGase; AltName: Full=Beta-glucocerebrosidase 2; Short=Beta-glucosidase 2; AltName: Full=Glucosylceramidase 2 [Rattus norvegicus]