Gene/Proteome Database (LMPD)
LMPD ID
LMP006561
Gene ID
Species
Mus musculus (Mouse)
Gene Name
fatty acid desaturase 1
Gene Symbol
Synonyms
0710001O03Rik; A930006B21Rik; AI317215; DSD
Alternate Names
fatty acid desaturase 1; D5D; delta-5 desaturase; delta(5) desaturase; delta(5) fatty acid desaturase
Chromosome
19
Map Location
19 A|19
EC Number
1.14.19.-
Proteins
| fatty acid desaturase 1 | |
|---|---|
| Refseq ID | NP_666206 |
| Protein GI | 22164784 |
| UniProt ID | Q920L1 |
| mRNA ID | NM_146094 |
| Length | 447 |
| RefSeq Status | VALIDATED |
| MAPDPVPTPGPASAQLRQTRYFTWEEVAQRSGREKERWLVIDRKVYNISDFSRRHPGGSRVISHYAGQDATDPFVAFHINKGLVRKYMNSLLIGELAPEQPSFEPTKNKALTDEFRELRATVERMGLMKANHLFFLVYLLHILLLDVAAWLTLWIFGTSLVPFILCAVLLSTVQAQAGWLQHDFGHLSVFGTSTWNHLLHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPLFFALGKVLPVELGREKKKHMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVVQRKKWVDLAWMLSFYARIFFTYMPLLGLKGFLGLFFIVRFLESNWFVWVTQMNHIPMHIDHDRNVDWVSTQLQATCNVHQSAFNNWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKYGIKYESKPLLTAFADIVYSLKESGQLWLDAYLHQ | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005739 | IEA:UniProtKB-KW | C | mitochondrion |
| GO:0005634 | IEA:Ensembl | C | nucleus |
| GO:0020037 | IEA:InterPro | F | heme binding |
| GO:0005506 | IEA:InterPro | F | iron ion binding |
| GO:0016717 | IEA:Ensembl | F | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water |
| GO:0007568 | IEA:Ensembl | P | aging |
| GO:0019369 | IEA:Ensembl | P | arachidonic acid metabolic process |
| GO:0009267 | IEA:Ensembl | P | cellular response to starvation |
| GO:0032868 | IEA:Ensembl | P | response to insulin |
| GO:0014070 | IEA:Ensembl | P | response to organic cyclic compound |
| GO:0009744 | IEA:Ensembl | P | response to sucrose |
| GO:0033189 | IEA:Ensembl | P | response to vitamin A |
| GO:0006636 | IEA:UniProtKB-UniPathway | P | unsaturated fatty acid biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| mmu01040 | Biosynthesis of unsaturated fatty acids |
REACTOME Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Domain | The histidine box domains may contain the active site and/or be involved in metal ion binding. |
| Function | Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3) respectively (By similarity). {ECO:0000250}. |
| Induction | Expression in liver is down-regulated by dietary PUFA. {ECO:0000269|PubMed:11792729}. |
| Pathway | Lipid metabolism; polyunsaturated fatty acid biosynthesis. |
| Similarity | Belongs to the fatty acid desaturase family. {ECO:0000305}. |
| Similarity | Contains 1 cytochrome b5 heme-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00279}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Mitochondrion {ECO:0000250}. |
| Tissue Specificity | Highly expressed in the adrenal gland, liver, brain, and testis, tissues where lipogenesis and steroidogenesis are active. {ECO:0000269|PubMed:11792729}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006561 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 22164784 | RefSeq | NP_666206 | 447 | fatty acid desaturase 1 |
Identical Sequences to LMP006561 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:22164784 | DBBJ | BAB69894.1 | 447 | delta-5 desaturase [Mus musculus] |
| GI:22164784 | DBBJ | BAC39079.1 | 447 | unnamed protein product [Mus musculus] |
| GI:22164784 | GenBank | AAH63053.1 | 447 | Fatty acid desaturase 1 [Mus musculus] |
| GI:22164784 | GenBank | EDL41339.1 | 447 | fatty acid desaturase 1 [Mus musculus] |
| GI:22164784 | GenBank | AHM63726.1 | 447 | fatty acid desaturase 1 [Mus musculus domesticus] |
| GI:22164784 | SwissProt | Q920L1.1 | 447 | RecName: Full=Fatty acid desaturase 1; AltName: Full=Delta(5) fatty acid desaturase; Short=D5D; Short=Delta(5) desaturase; Short=Delta-5 desaturase [Mus musculus] |
Related Sequences to LMP006561 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:22164784 | DBBJ | BAE32539.1 | 447 | unnamed protein product [Mus musculus] |
| GI:22164784 | GenBank | AAH22139.1 | 447 | Fatty acid desaturase 1 [Mus musculus] |
| GI:22164784 | GenBank | AAH26848.1 | 447 | Fatty acid desaturase 1 [Mus musculus] |
| GI:22164784 | GenBank | AAH26831.1 | 447 | Fatty acid desaturase 1 [Mus musculus] |
| GI:22164784 | GenBank | EDM12791.1 | 447 | fatty acid desaturase 1, isoform CRA_a [Rattus norvegicus] |
| GI:22164784 | RefSeq | NP_445897.2 | 447 | fatty acid desaturase 1 [Rattus norvegicus] |