Gene/Proteome Database (LMPD)

LMPD ID
LMP006565
Gene ID
74754
Species
Mus musculus (Mouse)
Gene Name
24-dehydrocholesterol reductase
Gene Symbol
Dhcr24
Synonyms
2310076D10Rik; 5830417J06Rik; mKIAA0018
Alternate Names
delta(24)-sterol reductase; seladin-1; 3-beta-hydroxysterol delta-24 reductase; 3-beta-hydroxysterol delta-24-reductase
Chromosome
4
Map Location
4 C7|4
EC Number
1.3.1.72

Proteins

delta(24)-sterol reductase precursor
Refseq ID NP_444502
Protein GI 114155129
UniProt ID Q8VCH6
mRNA ID NM_053272
Length 516
RefSeq Status VALIDATED
MEPAVSLAVCALLFLLWVRVKGLEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKLSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVSMGQVTALLNSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELILADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICEKFTRESQRLENHFVEGLLYSLDEAVIMTGVMTDDVEPSKLNSIGSYYKPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCMSQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGDEAELYVDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLRKQLGCQDAFPEVYDKICKAARH
sig_peptide: 1..22 calculated_mol_wt: 2416 peptide sequence: MEPAVSLAVCALLFLLWVRVKG mat_peptide: 23..516 product: delta(24)-sterol reductase calculated_mol_wt: 57715 peptide sequence: LEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKLSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVSMGQVTALLNSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELILADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICEKFTRESQRLENHFVEGLLYSLDEAVIMTGVMTDDVEPSKLNSIGSYYKPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCMSQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGDEAELYVDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLRKQLGCQDAFPEVYDKICKAARH

Gene Information

Entrez Gene ID
74754
Gene Name
24-dehydrocholesterol reductase
Gene Symbol
Dhcr24
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005856 IEA:Ensembl C cytoskeleton
GO:0005829 IEA:Ensembl C cytosol
GO:0005783 ISS:UniProtKB C endoplasmic reticulum
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005634 ISS:UniProtKB C nucleus
GO:0050614 IEA:UniProtKB-EC F delta24-sterol reductase activity
GO:0019899 ISS:UniProtKB F enzyme binding
GO:0050660 IEA:InterPro F flavin adenine dinucleotide binding
GO:0016628 ISO:MGI F oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0042605 ISS:UniProtKB F peptide antigen binding
GO:0008762 IEA:InterPro F UDP-N-acetylmuramate dehydrogenase activity
GO:0042987 IMP:MGI P amyloid precursor protein catabolic process
GO:0006695 IMP:UniProtKB P cholesterol biosynthetic process
GO:0008203 IMP:MGI P cholesterol metabolic process
GO:0030539 IMP:MGI P male genitalia development
GO:0061024 IMP:MGI P membrane organization
GO:0043066 ISS:UniProtKB P negative regulation of apoptotic process
GO:0008285 IEA:Ensembl P negative regulation of cell proliferation
GO:0043154 ISS:UniProtKB P negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0031639 IMP:MGI P plasminogen activation
GO:0008104 IMP:MGI P protein localization
GO:0007265 IEA:Ensembl P Ras protein signal transduction
GO:0009725 IEA:Ensembl P response to hormone
GO:0006979 ISS:UniProtKB P response to oxidative stress
GO:0043588 IMP:UniProtKB P skin development
GO:0016125 IMP:MGI P sterol metabolic process
GO:0009888 ISS:UniProtKB P tissue development

KEGG Pathway Links

KEGG Pathway ID Description
mmu00100 Steroid biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5893434 Cholesterol biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2
IPR016166 FAD-binding, type 2
IPR006094 FAD linked oxidase, N-terminal

UniProt Annotations

Entry Information

Gene Name
24-dehydrocholesterol reductase
Protein Entry
DHC24_MOUSE
UniProt ID
Q8VCH6
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 5-alpha-cholest-7-en-3-beta-ol + NADP(+) = 5- alpha-cholesta-7,24-dien-3-beta-ol + NADPH.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
Function Catalyzes the reduction of the delta-24 double bond of sterol intermediates. {ECO:0000250}.
Pathway Steroid biosynthesis; cholesterol biosynthesis.
Sequence Caution Sequence=BAC97846.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the FAD-binding oxidoreductase/transferase type 4 family. {ECO:0000305}.
Similarity Contains 1 FAD-binding PCMH-type domain. {ECO:0000255|PROSITE-ProRule:PRU00718}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006565 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
114155129 RefSeq NP_444502 516 delta(24)-sterol reductase precursor

Identical Sequences to LMP006565 proteins

Reference Database Accession Length Protein Name
GI:114155129 GenBank AAH19797.1 516 24-dehydrocholesterol reductase [Mus musculus]
GI:114155129 GenBank EDL30812.1 516 24-dehydrocholesterol reductase [Mus musculus]
GI:114155129 SwissProt Q8VCH6.1 516 RecName: Full=Delta(24)-sterol reductase; AltName: Full=24-dehydrocholesterol reductase; AltName: Full=3-beta-hydroxysterol delta-24-reductase; Flags: Precursor [Mus musculus]

Related Sequences to LMP006565 proteins

Reference Database Accession Length Protein Name
GI:114155129 DBBJ BAC97846.1 559 mKIAA0018 protein, partial [Mus musculus]
GI:114155129 GenBank AAX29968.2 516 24-dehydrocholesterol reductase [Rattus norvegicus]
GI:114155129 GenBank EDL90471.1 516 rCG50449 [Rattus norvegicus]
GI:114155129 RefSeq XP_005072237.1 516 PREDICTED: delta(24)-sterol reductase [Mesocricetus auratus]
GI:114155129 RefSeq XP_006987262.1 516 PREDICTED: delta(24)-sterol reductase [Peromyscus maniculatus bairdii]
GI:114155129 SwissProt Q5BQE6.2 516 RecName: Full=Delta(24)-sterol reductase; AltName: Full=24-dehydrocholesterol reductase; AltName: Full=3-beta-hydroxysterol delta-24-reductase; Flags: Precursor [Rattus norvegicus]