Gene/Proteome Database (LMPD)

LMPD ID
LMP006566
Gene ID
52665
Species
Mus musculus (Mouse)
Gene Name
enoyl Coenzyme A hydratase domain containing 1
Gene Symbol
Echdc1
Synonyms
1700028A24Rik; AI314462; AI930038; D10Ertd667e; MMCD
Alternate Names
ethylmalonyl-CoA decarboxylase; methylmalonyl-CoA decarboxylase; enoyl-CoA hydratase domain-containing protein 1
Chromosome
10
Map Location
10 A4|10 16.59 cM
EC Number
4.1.1.94

Proteins

ethylmalonyl-CoA decarboxylase isoform a
Refseq ID NP_080131
Protein GI 158854020
UniProt ID Q9D9V3
mRNA ID NM_025855
Length 322
RefSeq Status VALIDATED
MRRCEVNSKPISEYFGIPCENREMAKCLLTSSLSVRTKLLQTGVSLYNTSHGFHEEEVKKILEQFPGGSIDLLKKQNGIGILTLNNPNKMNAFSGVMMLQLLERVIELENWTEGKGLIIHGAKNTFCSGSDLNAVKALSTPESGVALSMFMQNTLTRFMRLPLISVALVQGWAMGGGAELTTACDFRLMTEESVIRFVHKEMGIVPSWGGTSRLVEIIGSRQALKVLSGTLKLDSKEALNIGLTDEVLQPSDETTALEQAQEWLEKFVSGPPQVIRGLKKSVCSARELYIEEALQNERDVLETLWGGPANLEAIAKKGKHTK
ethylmalonyl-CoA decarboxylase isoform b
Refseq ID NP_001103665
Protein GI 158854022
UniProt ID Q9D9V3
mRNA ID NM_001110195
Length 299
RefSeq Status VALIDATED
MAKCLLTSSLSVRTKLLQTGVSLYNTSHGFHEEEVKKILEQFPGGSIDLLKKQNGIGILTLNNPNKMNAFSGVMMLQLLERVIELENWTEGKGLIIHGAKNTFCSGSDLNAVKALSTPESGVALSMFMQNTLTRFMRLPLISVALVQGWAMGGGAELTTACDFRLMTEESVIRFVHKEMGIVPSWGGTSRLVEIIGSRQALKVLSGTLKLDSKEALNIGLTDEVLQPSDETTALEQAQEWLEKFVSGPPQVIRGLKKSVCSARELYIEEALQNERDVLETLWGGPANLEAIAKKGKHTK

Gene Information

Entrez Gene ID
52665
Gene Name
enoyl Coenzyme A hydratase domain containing 1
Gene Symbol
Echdc1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:UniProtKB C cytosol
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0016831 IDA:UniProtKB F carboxy-lyase activity
GO:0004492 IEA:UniProtKB-EC F methylmalonyl-CoA decarboxylase activity
GO:0008152 IDA:UniProtKB P metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00640 Propanoate metabolism
mmu00640 Propanoate metabolism

Domain Information

InterPro Annotations

Accession Description
IPR029045 ClpP/crotonase-like domain
IPR001753 Crotonase_core_superfam
IPR018376 Enoyl-CoA hydratase/isomerase, conserved site

UniProt Annotations

Entry Information

Gene Name
enoyl Coenzyme A hydratase domain containing 1
Protein Entry
ECHD1_MOUSE
UniProt ID
Q9D9V3
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9D9V3-1; Sequence=Displayed; Name=2; IsoId=Q9D9V3-2; Sequence=VSP_022499; Note=No experimental confirmation available.;
Biophysicochemical Properties Kinetic parameters: KM=0.96 uM for (S)-ethylmalonyl-CoA (in presence of 0 mM of ATP) {ECO:0000269|PubMed:22016388}; KM=6.5 uM for (S)-ethylmalonyl-CoA (in presence of 5 mM of ATP) {ECO:0000269|PubMed:22016388}; KM=3.1 uM for (S)-methylmalonyl-CoA (in presence of 0 mM of ATP) {ECO:0000269|PubMed:22016388}; KM=15.1 uM for (S)-methylmalonyl-CoA (in presence of 5 mM of ATP) {ECO:0000269|PubMed:22016388};
Catalytic Activity (S)-ethylmalonyl-CoA = butanoyl-CoA + CO(2). {ECO:0000269|PubMed:22016388}.
Catalytic Activity (S)-methylmalonyl-CoA = propanoyl-CoA + CO(2). {ECO:0000269|PubMed:22016388}.
Function Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level. {ECO:0000269|PubMed:22016388}.
Similarity Belongs to the enoyl-CoA hydratase/isomerase family. {ECO:0000305}.
Subcellular Location Cytoplasm, cytosol {ECO:0000305|PubMed:22016388}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006566 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
158854020 RefSeq NP_080131 322 ethylmalonyl-CoA decarboxylase isoform a
158854022 RefSeq NP_001103665 299 ethylmalonyl-CoA decarboxylase isoform b

Identical Sequences to LMP006566 proteins

Reference Database Accession Length Protein Name
GI:158854020 DBBJ BAB24592.2 322 unnamed protein product [Mus musculus]
GI:158854020 DBBJ BAE38876.1 322 unnamed protein product [Mus musculus]
GI:158854022 DBBJ BAE32007.1 299 unnamed protein product [Mus musculus]
GI:158854020 DBBJ BAE38907.1 322 unnamed protein product [Mus musculus]
GI:158854020 DBBJ BAE38924.1 322 unnamed protein product [Mus musculus]
GI:158854022 DBBJ BAE29969.1 299 unnamed protein product [Mus musculus]
GI:158854022 DBBJ BAE31098.1 299 unnamed protein product [Mus musculus]
GI:158854020 GenBank AAH66183.1 322 Enoyl Coenzyme A hydratase domain containing 1 [Mus musculus]
GI:158854022 GenBank EDL04835.1 299 enoyl Coenzyme A hydratase domain containing 1, isoform CRA_a [Mus musculus]
GI:158854022 GenBank EDL04836.1 299 enoyl Coenzyme A hydratase domain containing 1, isoform CRA_a [Mus musculus]
GI:158854022 GenBank EDL04837.1 299 enoyl Coenzyme A hydratase domain containing 1, isoform CRA_a [Mus musculus]
GI:158854020 SwissProt Q9D9V3.2 322 RecName: Full=Ethylmalonyl-CoA decarboxylase; AltName: Full=Enoyl-CoA hydratase domain-containing protein 1; AltName: Full=Methylmalonyl-CoA decarboxylase; Short=MMCD [Mus musculus]

Related Sequences to LMP006566 proteins

Reference Database Accession Length Protein Name
GI:158854020 DBBJ BAC26112.1 322 unnamed protein product [Mus musculus]
GI:158854022 DBBJ BAB24592.2 322 unnamed protein product [Mus musculus]
GI:158854022 DBBJ BAE38907.1 322 unnamed protein product [Mus musculus]
GI:158854022 DBBJ BAE38924.1 322 unnamed protein product [Mus musculus]
GI:158854020 DBBJ BAE26268.1 322 unnamed protein product [Mus musculus]
GI:158854022 GenBank AAH66183.1 322 Enoyl Coenzyme A hydratase domain containing 1 [Mus musculus]
GI:158854020 GenBank EDL04836.1 299 enoyl Coenzyme A hydratase domain containing 1, isoform CRA_a [Mus musculus]
GI:158854020 GenBank EDL04837.1 299 enoyl Coenzyme A hydratase domain containing 1, isoform CRA_a [Mus musculus]
GI:158854022 RefSeq NP_080131.4 322 ethylmalonyl-CoA decarboxylase isoform a [Mus musculus]
GI:158854020 RefSeq NP_001103665.1 299 ethylmalonyl-CoA decarboxylase isoform b [Mus musculus]
GI:158854020 RefSeq XP_006512860.1 374 PREDICTED: ethylmalonyl-CoA decarboxylase isoform X1 [Mus musculus]
GI:158854022 SwissProt Q9D9V3.2 322 RecName: Full=Ethylmalonyl-CoA decarboxylase; AltName: Full=Enoyl-CoA hydratase domain-containing protein 1; AltName: Full=Methylmalonyl-CoA decarboxylase; Short=MMCD [Mus musculus]