Gene/Proteome Database (LMPD)

LMPD ID
LMP006571
Gene ID
85031
Species
Mus musculus (Mouse)
Gene Name
phospholipase A1 member A
Gene Symbol
Pla1a
Synonyms
AA986889; Ps-pla1; Pspla1
Alternate Names
phospholipase A1 member A; phosphatidylserine-specific phospholipase A1
Chromosome
16
Map Location
16 B4|16 26.83 cM
EC Number
3.1.1.-

Proteins

phospholipase A1 member A precursor
Refseq ID NP_598863
Protein GI 164519080
UniProt ID Q8VI78
mRNA ID NM_134102
Length 456
RefSeq Status VALIDATED
MRPGLWETCFWLWGPLLWLSIGSSGNVPPTTQPKCTDFQSANLLRGTNLKVQFLLFTPSDPSCGQLVEEGSDIRSSEFNASLGTKVIIHGFRALGTKPSWIDKFISAVLRAADANVIAVDWVYGSTGVYYSAVENVVKLSLEISRFLSKLLELGVSESSIHIIGVSLGAHVGGMVGHFYKGQLGQITGLDPAGPEYTRASLEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPAFFHAGYNYLICDHMRAVHLYISALENTCPLMAFPCASYKAFLAGDCLDCFNPFLLSCPRIGLVERGGVMIEPLPKEVKVYLLTTSSAPYCVHHSLVEFYLKEKRKKDTSIEVTFLSNNVTSSVKITIPKQQLEGRGVMAHPNPQCQINQVKLKFQVSSRVWRKDRTPVVGTFCTAPLPVNDSKKTVCIPEPVRLQAGVPAFQDLKIACV
sig_peptide: 1..25 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (Q8VI78.3) calculated_mol_wt: 2893 peptide sequence: MRPGLWETCFWLWGPLLWLSIGSSG mat_peptide: 26..456 product: Phospholipase A1 member A experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q8VI78.3) calculated_mol_wt: 47109 peptide sequence: NVPPTTQPKCTDFQSANLLRGTNLKVQFLLFTPSDPSCGQLVEEGSDIRSSEFNASLGTKVIIHGFRALGTKPSWIDKFISAVLRAADANVIAVDWVYGSTGVYYSAVENVVKLSLEISRFLSKLLELGVSESSIHIIGVSLGAHVGGMVGHFYKGQLGQITGLDPAGPEYTRASLEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPAFFHAGYNYLICDHMRAVHLYISALENTCPLMAFPCASYKAFLAGDCLDCFNPFLLSCPRIGLVERGGVMIEPLPKEVKVYLLTTSSAPYCVHHSLVEFYLKEKRKKDTSIEVTFLSNNVTSSVKITIPKQQLEGRGVMAHPNPQCQINQVKLKFQVSSRVWRKDRTPVVGTFCTAPLPVNDSKKTVCIPEPVRLQAGVPAFQDLKIACV

Gene Information

Entrez Gene ID
85031
Gene Name
phospholipase A1 member A
Gene Symbol
Pla1a
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0002080 IDA:MGI C acrosomal membrane
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0008970 IDA:MGI F phosphatidylcholine 1-acylhydrolase activity
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04014 Ras signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR013818 Lipase, N-terminal
IPR016272 Lipoprotein_lipase_LIPH
IPR000734 Triacylglycerol lipase family

UniProt Annotations

Entry Information

Gene Name
phospholipase A1 member A
Protein Entry
PLA1A_MOUSE
UniProt ID
Q8VI78
Species
Mouse

Comments

Comment Type Description
Function Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1- acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production (By similarity). {ECO:0000250}.
Similarity Belongs to the AB hydrolase superfamily. Lipase family. {ECO:0000305}.
Subcellular Location Secreted {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006571 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
164519080 RefSeq NP_598863 456 phospholipase A1 member A precursor

Identical Sequences to LMP006571 proteins

Reference Database Accession Length Protein Name
GI:164519080 RefSeq XP_006522834.1 456 PREDICTED: phospholipase A1 member A isoform X1 [Mus musculus]
GI:164519080 RefSeq XP_006522835.1 456 PREDICTED: phospholipase A1 member A isoform X2 [Mus musculus]
GI:164519080 SwissProt Q8VI78.3 456 RecName: Full=Phospholipase A1 member A; AltName: Full=Phosphatidylserine-specific phospholipase A1; Short=PS-PLA1; Flags: Precursor [Mus musculus]

Related Sequences to LMP006571 proteins

Reference Database Accession Length Protein Name
GI:164519080 GenBank AAH03470.1 456 Phospholipase A1 member A [Mus musculus]
GI:164519080 GenBank AAL55475.1 456 phosphatidylserine-specific phospholipase A1 [Mus musculus]
GI:164519080 GenBank AAH30670.1 456 Phospholipase A1 member A [Mus musculus]
GI:164519080 GenBank EDK97977.1 456 phospholipase A1 member A [Mus musculus]
GI:164519080 RefSeq NP_620237.1 456 phospholipase A1 member A precursor [Rattus norvegicus]
GI:164519080 SwissProt P97535.1 456 RecName: Full=Phospholipase A1 member A; AltName: Full=Phosphatidylserine-specific phospholipase A1; Short=PS-PLA1; Flags: Precursor [Rattus norvegicus]