Gene/Proteome Database (LMPD)

LMPD ID
LMP006576
Gene ID
78925
Species
Mus musculus (Mouse)
Gene Name
steroid 5 alpha-reductase 1
Gene Symbol
Srd5a1
Synonyms
0610031P22Rik; 4930435F02Rik; S5AR 1; Srd5a-1
Alternate Names
3-oxo-5-alpha-steroid 4-dehydrogenase 1; SR type 1; type 1 5alpha-reductase; steroid 5-alpha-reductase 1
Chromosome
13
Map Location
13 C1|13 35.55 cM
EC Number
1.3.1.22

Proteins

3-oxo-5-alpha-steroid 4-dehydrogenase 1
Refseq ID NP_780492
Protein GI 87044895
UniProt ID Q68FF9
mRNA ID NM_175283
Length 255
RefSeq Status VALIDATED
MELDELRLLDALVYLEGFLAFVAFVGLQMVGSSYGRYSSQWSGRRVPARPAWFLQELPSMAWPLYECIRPAAARLGNLPNRVLLAMFLIHYVQRTLVFPVLIRGGKPTLLFTFVLAFLFCTLNGYLQSRYLSQFAVYAEDWVTHPCFLTGFALWLVGMVINIHSDHILRNLRKPGETGYKIPRGGLFEYVSSANYFGELVEWCGFALASWSLQGVVFALFTLCALFTRARQHHQWYLEKFEDYPKTRKILIPFLL

Gene Information

Entrez Gene ID
78925
Gene Name
steroid 5 alpha-reductase 1
Gene Symbol
Srd5a1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0003865 ISS:UniProtKB F 3-oxo-5-alpha-steroid 4-dehydrogenase activity
GO:0047751 IEA:UniProtKB-EC F cholestenone 5-alpha-reductase activity
GO:0006702 IMP:MGI P androgen biosynthetic process
GO:0030154 IEA:UniProtKB-KW P cell differentiation
GO:0007548 IEA:UniProtKB-KW P sex differentiation

KEGG Pathway Links

KEGG Pathway ID Description
ko00140 Steroid hormone biosynthesis
mmu00140 Steroid hormone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5893451 Androgen biosynthesis
5893447 Metabolism of steroid hormones and vitamin D

Domain Information

InterPro Annotations

Accession Description
IPR016636 3-oxo-5-alpha-steroid 4-dehydrogenase
IPR001104 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal

UniProt Annotations

Entry Information

Gene Name
steroid 5 alpha-reductase 1
Protein Entry
S5A1_MOUSE
UniProt ID
Q68FF9
Species
Mouse

Comments

Comment Type Description
Catalytic Activity A 3-oxo-5-alpha-steroid + NADP(+) = a 3-oxo- Delta(4)-steroid + NADPH.
Function Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity). {ECO:0000250}.
Similarity Belongs to the steroid 5-alpha reductase family. {ECO:0000305}.
Subcellular Location Microsome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006576 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
87044895 RefSeq NP_780492 255 3-oxo-5-alpha-steroid 4-dehydrogenase 1

Identical Sequences to LMP006576 proteins

Reference Database Accession Length Protein Name
GI:87044895 GenBank AAH79863.1 255 Steroid 5 alpha-reductase 1 [Mus musculus]

Related Sequences to LMP006576 proteins

Reference Database Accession Length Protein Name
GI:87044895 GenBank AAA42102.1 255 steroid 5 alpha-reductase (EC 1.3.99.5) [Rattus norvegicus]
GI:87044895 GenBank AAA71247.1 255 Sequence 2 from patent US 5422262
GI:87044895 GenBank AAH94503.1 255 Steroid 5 alpha-reductase 1 [Mus musculus]
GI:87044895 GenBank EDL37018.1 255 steroid 5 alpha-reductase 1 [Mus musculus]
GI:87044895 RefSeq NP_058766.2 255 3-oxo-5-alpha-steroid 4-dehydrogenase 1 [Rattus norvegicus]
GI:87044895 SwissProt Q68FF9.2 255 RecName: Full=3-oxo-5-alpha-steroid 4-dehydrogenase 1; AltName: Full=SR type 1; AltName: Full=Steroid 5-alpha-reductase 1; Short=S5AR 1 [Mus musculus]