Gene/Proteome Database (LMPD)

LMPD ID
LMP006580
Gene ID
107476
Species
Mus musculus (Mouse)
Gene Name
acetyl-Coenzyme A carboxylase alpha
Gene Symbol
Acaca
Synonyms
A530025K05Rik; Acac; Acc1; Gm738
Chromosome
11
Map Location
11 C|11

Proteins

acetyl-CoA carboxylase 1
Refseq ID NP_579938
Protein GI 125656173
UniProt ID Q5SWU9
mRNA ID NM_133360
Length 2345
RefSeq Status VALIDATED
MDEPSPLAKTLELNQHSRFIIGSVSEDNSEDEISNLVKLDLEEKEGSLSPASVSSDTLSDLGISGLQDGLAFHMRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQDLYEKGYVKDVDDGLKAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPAAIATPAVFEHMEQCAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPLFRIKDIRMMYGVSPWGDAPIDFENSAHVPCPRGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGYFSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLIKLLETESFQLNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLRNSISNFLHSLERGQVLPAHTLLNTVDVELIYEGIKYVLKVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYRITIGNKTCVFEKENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYAEIEVMKMVMTLTAVESGCIHYVKRPGAALDPGCVIAKMQLDNPSKVQQAELHTGSLPQIQSTALRGEKLHRVFHYVLDNLVNVMNGYCLPDPFFSSRVKDWVERLMKTLRDPSLPLLELQDIMTSVSGRIPLNVEKSIKKEMAQYASNITSVLCQFPSQQIANILDSHAATLNRKSEREVFFMNTQSIVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQNGHYDKCVFALREENKSDMNTVLNYIFSHAQVTKKNLLVTMLIDQLCGRDPTLTDELLNILTELTQLSKTTNAKVALRARQVLIASHLPSYELRHNQVESIFLSAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYELNSVQHRQLKDNTCVVEFQFMLPTSHPNRGNIPTLNRMSFASNLNHYGMTHVASVSDVLLDNAFTPPCQRMGGMVSFRTFEDFVRIFDEIMGCFCDSPPQSPTFPESGHTSLYDEDKVPRDEPIHILNVAIKTDGDIEDDRLAAMFREFTQQNKATLVEHGIRRLTFLVAQKDFRKQVNCEVDQRFHREFPKFFTFRARDKFEEDRIYRHLEPALAFQLELNRMRNFDLTAIPCANHKMHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFEYLQNEGERLLLEAMDELEVAFNNTNVRTDCNHIFLNFVPTVIMDPSKIEESVRSMVMRYGSRLWKLRVLQAELKINIRLTTTGKAIPIRLFLTNESGYYLDISLYKEVTDSRTAQIMFQAYGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDILTYTELVLDDQGQLVHMNRLPGGNEIGMVAWKMSLKSPEYPDGRDIIVIGNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVAANSGARIGLAEEIRHMFHVAWVDPEDPYKGYKYLYLTPQDYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGLGAENLRGSGMIAGESSLAYDEVITISLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGREVYTSNNQLGGIQIMHNNGVTHSTVCDDFEGVFTVLHWLSYMPKSVHSSVPLLNSKDPIDRIIEFVPTKAPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGGIPVGVVAVETRTVELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECSQPVMVYIPPQAELRGGSWVVIDPTINPRHMEMYADRESRGSVLEPEGTVEIKFRKKDLVKTMRRVDPVYIRLAERLGTPELSPTERKELESKLKEREEFLIPIYHQVAVQFADLHDTPGRMQEKGVINDILDWKTSRTFFYWRLRRLLLEDLVKKKIHNANPELTDGQIQAMLRRWFVEVEGTVKAYVWDNNKDLVEWLEKQLTEEDGVRSVIEENIKYISRDYVLKQIRSLVQANPEVAMDSIVHMTQHISPTQRAEVVRILSTMDSPST

Gene Information

Entrez Gene ID
107476
Gene Name
acetyl-Coenzyme A carboxylase alpha
Gene Symbol
Acaca
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:UniProtKB C cytosol
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005739 IDA:MGI C mitochondrion
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003989 IDA:UniProtKB F acetyl-CoA carboxylase activity
GO:0004075 IEA:UniProtKB-EC F biotin carboxylase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006084 IDA:UniProtKB P acetyl-CoA metabolic process
GO:0006633 IDA:UniProtKB P fatty acid biosynthetic process
GO:0055088 IMP:MGI P lipid homeostasis
GO:0006629 IMP:MGI P lipid metabolic process
GO:2001295 IEA:UniProtKB-UniPathway P malonyl-CoA biosynthetic process
GO:0044268 IMP:MGI P multicellular organismal protein metabolic process
GO:0051289 IDA:UniProtKB P protein homotetramerization
GO:0001894 IMP:MGI P tissue homeostasis

Domain Information

InterPro Annotations

Accession Description
IPR011761 ATP-grasp fold
IPR013815 ATP-grasp fold, subdomain 1
IPR013816 ATP-grasp fold, subdomain 2
IPR013537 Acetyl-CoA carboxylase, central domain
IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminal
IPR011762 Acetyl-coenzyme A carboxyltransferase, N-terminal
IPR005482 Biotin carboxylase, C-terminal
IPR011764 Biotin carboxylation domain
IPR001882 Biotin-binding site
IPR000089 Biotin/lipoyl attachment
IPR005481 Carbamoyl-phosphate synthase, large subunit, N-terminal
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
IPR000022 Carboxyl transferase
IPR029045 ClpP/crotonase-like domain
IPR016185 Pre-ATP-grasp domain
IPR011054 Rudiment single hybrid motif
IPR011053 Single hybrid motif

UniProt Annotations

Entry Information

Gene Name
acetyl-Coenzyme A carboxylase alpha
Protein Entry
Q5SWU9_MOUSE
UniProt ID
Q5SWU9
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative promoter usage; Named isoforms=2; Name=1; IsoId=Q5SWU9-1; Sequence=Displayed; Name=2; IsoId=Q5SWU9-2; Sequence=VSP_026101;
Catalytic Activity ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA. {ECO:0000250|UniProtKB:P11497, ECO:0000269|PubMed:20952656}.
Catalytic Activity ATP + biotin-[carboxyl-carrier-protein] + CO(2) = ADP + phosphate + carboxy-biotin-[carboxyl-carrier- protein].
Cofactor Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ; Note=Binds 2 manganese ions per subunit. ;
Cofactor Name=biotin; Xref=ChEBI:CHEBI:57586; Evidence= ; Note=Biotin. ;
Enzyme Regulation By phosphorylation (By similarity). Activity is increased by oligomerization. Citrate and MID1IP1 promote oligomerization.
Function Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (By similarity).
Pathway Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
Ptm Phosphorylation on Ser-1262 is required for interaction with BRCA1.
Similarity Contains 1 ATP-grasp domain. {ECO:0000255|PROSITE- ProRule:PRU00409}.
Similarity Contains 1 biotin carboxylation domain.
Similarity Contains 1 biotinyl-binding domain.
Similarity Contains 1 carboxyltransferase domain.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:12360400, ECO:0000269|PubMed:20952656}.
Subunit Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity. {ECO:0000269|PubMed:12360400, ECO:0000269|PubMed:20952656}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006580 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
125656173 RefSeq NP_579938 2345 acetyl-CoA carboxylase 1

Identical Sequences to LMP006580 proteins

Reference Database Accession Length Protein Name
GI:125656173 GenBank AAI56145.1 2345 Acetyl-Coenzyme A carboxylase alpha, partial [synthetic construct]
GI:125656173 GenBank AAI56983.1 2345 Acetyl-Coenzyme A carboxylase alpha [synthetic construct]
GI:125656173 RefSeq XP_006532017.1 2345 PREDICTED: acetyl-CoA carboxylase 1 isoform X4 [Mus musculus]
GI:125656173 RefSeq XP_006532018.1 2345 PREDICTED: acetyl-CoA carboxylase 1 isoform X5 [Mus musculus]
GI:125656173 RefSeq XP_006532019.1 2345 PREDICTED: acetyl-CoA carboxylase 1 isoform X6 [Mus musculus]
GI:125656173 RefSeq XP_006532020.1 2345 PREDICTED: acetyl-CoA carboxylase 1 isoform X7 [Mus musculus]

Related Sequences to LMP006580 proteins

Reference Database Accession Length Protein Name
GI:125656173 EMBL CBF60000.1 2345 unnamed protein product [Rattus norvegicus]
GI:125656173 EMBL CBF60635.1 2345 unnamed protein product [Rattus norvegicus]
GI:125656173 RefSeq XP_006532014.1 2423 PREDICTED: acetyl-CoA carboxylase 1 isoform X1 [Mus musculus]
GI:125656173 RefSeq XP_006532016.1 2383 PREDICTED: acetyl-CoA carboxylase 1 isoform X3 [Mus musculus]
GI:125656173 RefSeq XP_006983230.1 2384 PREDICTED: acetyl-CoA carboxylase 1 isoform X1 [Peromyscus maniculatus bairdii]
GI:125656173 RefSeq XP_006983232.1 2346 PREDICTED: acetyl-CoA carboxylase 1 isoform X3 [Peromyscus maniculatus bairdii]