Gene/Proteome Database (LMPD)

LMPD ID
LMP006588
Gene ID
269437
Species
Mus musculus (Mouse)
Gene Name
phospholipase C, eta 1
Gene Symbol
Plch1
Synonyms
BC042549; PLCeta1; Plcl3
Alternate Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1; PLC-eta-1; phospholipase C-like protein 3; phosphoinositide phospholipase C-eta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-1
Chromosome
3
Map Location
3 E1|3
EC Number
3.1.4.11

Proteins

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 1
Refseq ID NP_899014
Protein GI 295148200
UniProt ID Q4KWH5
mRNA ID NM_183191
Length 1682
RefSeq Status VALIDATED
MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMSNVTLDYCLDIIMKFEVSEENKVKNVLGIEGFTNFMRSPACDVFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGILQDKLDLSSVDTGECRQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQNLDVKESGKKSHGRSLMANFGKHKQKATKSRSKSYSTDDEDDSLQNPGKEGGQLYRLGRRRRTMKLCRELSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQINRAKFKANGNCGYILKPQQMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEIFGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHASSENNSHYVRKRSIGDRILRRTASAPAKGRKKSKVGFQEMVEIKDSVSEASRDQDGVLRRTTRSLQVRPVSMPVDKSLLGALSLPISEAAKDTDGKENCLAGDKDDRRKGAATRKDPHFSNFNKKLSSSSSALLHKDANQGPTASVSNPEQCGGRGAKSERIKPNMTNDCQENHNPPKFLSPRKHLALDPATKGLQERLHGMKTNEKEHAEGFLGEKSMLSGSVLSQSSLEVENLEGSRAKGRAATSFSLSDVSALCSDIPDLHSTAILQDTEISNLIDDVTLTNENQSGSSISALIGQFEESNHPANVTVVSHLSTSGASGSAPFQTPFKHGLSQGNQKASFLCSSPELNKLSSVETTKLANNAVPCGVIGSPISTPKPGDDPSDKAKTRVIEGNLPGFPDASPGQFPKSPTHGEDHSQVMNSPALSTELAIEDIIADPALSINSAESSLVEIDGESENLSLTTCDYREEAPSQLVSPLKLQQSQEMVEHIQRGLRNGYCKETLLPSEIFNNIPGVKNHSISHLTYQGAGFVYNHFSSSDAKTNQICEPQQPRAPDMHAPTPTPSTHAPLAALKLPSPCKSKSLGDLTSEDIACNFESKYQCISRSFVTNGIRDKSVTMKTKSLEPLDALTEQLRKLVSFDQEDSCQVLYSKQDVNQCPRALVRKLSSRSQSRVRNIASRAKEKQEAGKQKAMAQSTRGGVVLRSKPPAPALAVNRHSTGSYIASYLRNMKAGGLEGRGIPEGACTALRYGYMDQFCSDNSVLQTEPSSEDKPEIYFLLRL
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 2
Refseq ID NP_001171204
Protein GI 295148204
UniProt ID Q4KWH5
mRNA ID NM_001177733
Length 1073
RefSeq Status VALIDATED
MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMSNVTLDYCLDIIMKFEVSEENKVKNVLGIEGFTNFMRSPACDVFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGILQDKLDLSSVDTGECRQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQNLDVKESGKKSHGRSLMANFGKHKQKATKSRSKSYSTDDEDDSLQNPGKEGGQLYRLGRRRRTMKLCRELSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQINRAKFKANGNCGYILKPQQMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEIFGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHASSENNSHYVRKRSIGDRILRRTASAPAKGRKKSKVGFQEMVEIKDSVSEASRDQDGVLRRTTRSLQVRPVSMPVDKSLLGALSLPISEAAKDTDGKENCLDLNRKQRKQETRMTEEREPQLEKTHIFQISTKSYPPPPVRSSTKMPTKGQLPVYQTQNSVEDEVQRVRGSNQI
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 3
Refseq ID NP_001171203
Protein GI 295148202
UniProt ID Q4KWH5
mRNA ID NM_001177732
Length 1003
RefSeq Status VALIDATED
MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMSNVTLDYCLDIIMKFEVSEENKVKNVLGIEGFTNFMRSPACDVFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGILQDKLDLSSVDTGECRQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQNLDVKESGKKSHGRSLMANFGKHKQKATKSRSKSYSTDDEDDSLQNPGKEGGQLYRLGRRRRTMKLCRELSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQINRAKFKANGNCGYILKPQQMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEIFGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHASSENNSHYVRKRSIGDRILRRTASAPAKGRKKSKVGFQEMVEIKDSVSEASRDQDGVLRRTTRSLQVRPVSMPVDKSLLGALSLPISEAAKDTDGKENCLVQI

Gene Information

Entrez Gene ID
269437
Gene Name
phospholipase C, eta 1
Gene Symbol
Plch1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 ISA:MGI C cytoplasm
GO:0005829 IDA:MGI C cytosol
GO:0016020 IDA:MGI C membrane
GO:0005509 IEA:InterPro F calcium ion binding
GO:0050429 ISA:MGI F calcium-dependent phospholipase C activity
GO:0004435 IEA:UniProtKB-EC F phosphatidylinositol phospholipase C activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0048015 ISA:MGI P phosphatidylinositol-mediated signaling

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis
PWY3DJ-219 PIP metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5894026 Inositol phosphate metabolism
5894025 Synthesis of IP3 and IP4 in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR028392 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
IPR000008 C2 domain
IPR018247 EF-Hand 1, calcium-binding site
IPR002048 EF-hand domain
IPR011992 EF-hand domain pair
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
phospholipase C, eta 1
Protein Entry
PLCH1_MOUSE
UniProt ID
Q4KWH5
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=PLC-eta-1; IsoId=Q4KWH5-1; Sequence=Displayed; Name=2; IsoId=Q4KWH5-2; Sequence=VSP_032908, VSP_032909, VSP_032911; Note=No experimental confirmation available.; Name=3; Synonyms=PLC-eta-1b; IsoId=Q4KWH5-3; Sequence=VSP_032912, VSP_032915; Name=4; Synonyms=PLC-eta-1a; IsoId=Q4KWH5-4; Sequence=VSP_032913, VSP_032914; Name=5; IsoId=Q4KWH5-5; Sequence=VSP_032907, VSP_032910, VSP_032911, VSP_032912, VSP_032915; Note=No experimental confirmation available.;
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|PubMed:15702972}.
Similarity Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Similarity Contains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
Similarity Contains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
Similarity Contains 2 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Subcellular Location Cytoplasm. Membrane {ECO:0000250}.
Tissue Specificity Expressed in brain and to a lower extent in lung. In brain, it is found in cerebrum, cerebellum and spinal cord. {ECO:0000269|PubMed:15702972}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006588 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
295148200 RefSeq NP_899014 1682 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 1
295148204 RefSeq NP_001171204 1073 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 2
295148202 RefSeq NP_001171203 1003 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 3

Identical Sequences to LMP006588 proteins

Reference Database Accession Length Protein Name
GI:295148202 GenBank AAW22609.1 1003 phospholipase C-eta1a [Mus musculus]
GI:295148204 GenBank AAW22610.1 1073 phospholipase C-eta1b [Mus musculus]
GI:295148200 GenBank AAW22611.1 1682 phospholipase C-eta1c [Mus musculus]
GI:295148200 SwissProt Q4KWH5.1 1682 RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1; AltName: Full=Phosphoinositide phospholipase C-eta-1; AltName: Full=Phospholipase C-eta-1; Short=PLC-eta-1; AltName: Full=Phospholipase C-like protein 3; Short=PLC-L3 [Mus musculus]

Related Sequences to LMP006588 proteins

Reference Database Accession Length Protein Name
GI:295148204 GenBank AAW22609.1 1003 phospholipase C-eta1a [Mus musculus]
GI:295148202 GenBank AAW22610.1 1073 phospholipase C-eta1b [Mus musculus]
GI:295148202 GenBank AAW22611.1 1682 phospholipase C-eta1c [Mus musculus]
GI:295148204 GenBank AAW22611.1 1682 phospholipase C-eta1c [Mus musculus]
GI:295148204 RefSeq NP_899014.2 1682 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 1 [Mus musculus]
GI:295148202 RefSeq NP_899014.2 1682 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 1 [Mus musculus]
GI:295148202 RefSeq NP_001171204.1 1073 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 2 [Mus musculus]
GI:295148204 RefSeq XP_006232508.1 1021 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X3 [Rattus norvegicus]
GI:295148200 RefSeq XP_006501593.1 1694 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1 [Mus musculus]
GI:295148202 RefSeq XP_006501594.1 1694 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X2 [Mus musculus]
GI:295148200 RefSeq XP_006501594.1 1694 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X2 [Mus musculus]
GI:295148200 RefSeq XP_006501595.1 1694 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X3 [Mus musculus]
GI:295148200 RefSeq XP_006501596.1 1694 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X4 [Mus musculus]
GI:295148200 RefSeq XP_006501597.1 1694 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5 [Mus musculus]
GI:295148200 RefSeq XP_006501599.1 1693 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X7 [Mus musculus]
GI:295148204 RefSeq XP_006501604.1 1084 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X12 [Mus musculus]
GI:295148204 SwissProt Q4KWH5.1 1682 RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1; AltName: Full=Phosphoinositide phospholipase C-eta-1; AltName: Full=Phospholipase C-eta-1; Short=PLC-eta-1; AltName: Full=Phospholipase C-like protein 3; Short=PLC-L3 [Mus musculus]
GI:295148202 SwissProt Q4KWH5.1 1682 RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1; AltName: Full=Phosphoinositide phospholipase C-eta-1; AltName: Full=Phospholipase C-eta-1; Short=PLC-eta-1; AltName: Full=Phospholipase C-like protein 3; Short=PLC-L3 [Mus musculus]