Gene/Proteome Database (LMPD)

LMPD ID
LMP006590
Gene ID
99712
Species
Mus musculus (Mouse)
Gene Name
choline/ethanolaminephosphotransferase 1
Gene Symbol
Cept1
Synonyms
9930118K05Rik; mCEPT1
Chromosome
3
Map Location
3 F2.3|3

Proteins

choline/ethanolaminephosphotransferase 1 isoform 1
Refseq ID NP_598630
Protein GI 31559983
UniProt ID Q8BGS7
mRNA ID NM_133869
Length 416
RefSeq Status VALIDATED
MSGHRSTRKRCGDSHPESPVGFGHMSTTGCVLNKLFQLPTPPLSRHQLKRLEEHRYQSAGRSLLEPLMQGYWEWLVGRVPSWIAPNLITIIGLSINICTTILLVFYCPTATEQAPLWAYIACACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTCIAVQLGTNPDWMFFCCFAGTFMFYCAHWQTYVSGTLRFGIIDVTEVQIFIIIMHLLAVIGGPPFWQSMIPVLNIQMKLLPALCTVAGTIFSCTNYFRVIFTGGVGKNGSTIAGTSVLSPFLHIGSVITLAVMIYKKSAVQLFEKHPCLYILTFGFVSAKITNKLVVAHMTKSEMHLHDTAFIGPALLFLDQYFNSFIDEYIVLWIALIFSFFDLIRYCVSVCNQIASHLHIHVFRIKASTAHSNHH
choline/ethanolaminephosphotransferase 1 isoform 2
Refseq ID NP_001280623
Protein GI 656214626
UniProt ID Q8BGS7
mRNA ID NM_001293694
Length 416
RefSeq Status VALIDATED
MSGHRSTRKRCGDSHPESPVGFGHMSTTGCVLNKLFQLPTPPLSRHQLKRLEEHRYQSAGRSLLEPLMQGYWEWLVGRVPSWIAPNLITIIGLSINICTTILLVFYCPTATEQAPLWAYIACACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTCIAVQLGTNPDWMFFCCFAGTFMFYCAHWQTYVSGTLRFGIFDVTESQILIILFQLLSGTVGPWFWNFTIPVLNIQMKLLPALCTVAGTIFSCTNYFRVIFTGGVGKNGSTIAGTSVLSPFLHIGSVITLAVMIYKKSAVQLFEKHPCLYILTFGFVSAKITNKLVVAHMTKSEMHLHDTAFIGPALLFLDQYFNSFIDEYIVLWIALIFSFFDLIRYCVSVCNQIASHLHIHVFRIKASTAHSNHH

Gene Information

Entrez Gene ID
99712
Gene Name
choline/ethanolaminephosphotransferase 1
Gene Symbol
Cept1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IDA:MGI C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0004142 IEA:UniProtKB-EC F diacylglycerol cholinephosphotransferase activity
GO:0004307 IEA:UniProtKB-EC F ethanolaminephosphotransferase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0016780 IDA:MGI F phosphotransferase activity, for other substituted phosphate groups
GO:0006656 IDA:MGI P phosphatidylcholine biosynthetic process
GO:0006646 IEA:UniProtKB-UniPathway P phosphatidylethanolamine biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00565 Ether lipid metabolism
mmu00565 Ether lipid metabolism
ko00564 Glycerophospholipid metabolism
mmu00564 Glycerophospholipid metabolism
mmu01100 Metabolic pathways
M00090 Phosphatidylcholine (PC) biosynthesis, choline => PC
M00092 Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-3561 choline biosynthesis III
PWY3O-450 phosphatidylcholine biosynthesis I
PWY4FS-6 phosphatidylethanolamine biosynthesis II

REACTOME Pathway Links

REACTOME Pathway ID Description
5892983 Glycerophospholipid biosynthesis
5892760 Metabolism
5892799 Metabolism of lipids and lipoproteins
5892984 Phospholipid metabolism
5893602 Synthesis of PC
5893984 Synthesis of PE

Domain Information

InterPro Annotations

Accession Description
IPR000462 CDP-alcohol phosphatidyltransferase
IPR014472 Choline/ethanolamine phosphotransferase

UniProt Annotations

Entry Information

Gene Name
choline/ethanolaminephosphotransferase 1
Protein Entry
Q8BGS7_MOUSE
UniProt ID
Q8BGS7
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BGS7-1; Sequence=Displayed; Name=2; IsoId=Q8BGS7-2; Sequence=VSP_025988; Note=No experimental confirmation available.;
Catalytic Activity CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine.
Catalytic Activity CDP-ethanolamine + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylethanolamine.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
Function Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity (By similarity). {ECO:0000250}.
Pathway Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.
Pathway Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3.
Similarity Belongs to the CDP-alcohol phosphatidyltransferase class-I family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Nucleus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006590 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31559983 RefSeq NP_598630 416 choline/ethanolaminephosphotransferase 1 isoform 1
656214626 RefSeq NP_001280623 416 choline/ethanolaminephosphotransferase 1 isoform 2

Identical Sequences to LMP006590 proteins

Reference Database Accession Length Protein Name
GI:31559983 DBBJ BAC29710.1 416 unnamed protein product [Mus musculus]
GI:656214626 GenBank AAH21753.1 416 Cept1 protein [Mus musculus]
GI:31559983 GenBank AAH23783.1 416 Choline/ethanolaminephosphotransferase 1 [Mus musculus]
GI:656214626 GenBank EDL01872.1 416 choline/ethanolaminephosphotransferase 1, isoform CRA_a [Mus musculus]
GI:31559983 GenBank EDL01873.1 416 choline/ethanolaminephosphotransferase 1, isoform CRA_b [Mus musculus]
GI:31559983 RefSeq XP_006502534.1 416 PREDICTED: choline/ethanolaminephosphotransferase 1 isoform X2 [Mus musculus]
GI:31559983 RefSeq XP_006502535.1 416 PREDICTED: choline/ethanolaminephosphotransferase 1 isoform X3 [Mus musculus]
GI:31559983 SwissProt Q8BGS7.1 416 RecName: Full=Choline/ethanolaminephosphotransferase 1; Short=mCEPT1 [Mus musculus]

Related Sequences to LMP006590 proteins

Reference Database Accession Length Protein Name
GI:31559983 GenBank AAH79471.1 416 Choline/ethanolamine phosphotransferase 1 [Rattus norvegicus]
GI:656214626 GenBank EAW56469.1 416 choline/ethanolamine phosphotransferase 1, isoform CRA_a [Homo sapiens]
GI:31559983 GenBank EDL81841.1 416 choline/ethanolamine phosphotransferase 1, isoform CRA_a [Rattus norvegicus]
GI:656214626 GenBank EDL81842.1 416 choline/ethanolamine phosphotransferase 1, isoform CRA_b [Rattus norvegicus]
GI:31559983 RefSeq NP_001007700.1 416 choline/ethanolaminephosphotransferase 1 [Rattus norvegicus]
GI:656214626 RefSeq XP_004581992.1 416 PREDICTED: choline/ethanolaminephosphotransferase 1 isoform X2 [Ochotona princeps]
GI:31559983 RefSeq XP_006233178.1 416 PREDICTED: choline/ethanolaminephosphotransferase 1 isoform X1 [Rattus norvegicus]
GI:656214626 RefSeq XP_006233179.1 416 PREDICTED: choline/ethanolaminephosphotransferase 1 isoform X2 [Rattus norvegicus]
GI:31559983 RefSeq XP_006233180.1 416 PREDICTED: choline/ethanolaminephosphotransferase 1 isoform X1 [Rattus norvegicus]
GI:656214626 RefSeq XP_008262921.1 416 PREDICTED: choline/ethanolaminephosphotransferase 1 isoform X2 [Oryctolagus cuniculus]
GI:656214626 RefSeq XP_009213377.1 416 PREDICTED: choline/ethanolaminephosphotransferase 1 isoform X2 [Papio anubis]
GI:31559983 SwissProt Q6AXM5.1 416 RecName: Full=Choline/ethanolaminephosphotransferase 1 [Rattus norvegicus]