Gene/Proteome Database (LMPD)
LMPD ID
LMP006593
Gene ID
Species
Mus musculus (Mouse)
Gene Name
phospholipase C, beta 2
Gene Symbol
Synonyms
AI550384; B230205M18Rik; B230399N12
Alternate Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; PLC-beta-2; phospholipase C-beta-2; phosphoinositide phospholipase C-beta-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2
Chromosome
2
Map Location
2 E5|2 59.43 cM
EC Number
3.1.4.11
Proteins
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform a | |
|---|---|
| Refseq ID | NP_808236 |
| Protein GI | 61676179 |
| UniProt ID | A3KGF7 |
| mRNA ID | NM_177568 |
| Length | 1181 |
| RefSeq Status | VALIDATED |
| MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQNQEMEFLDVTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKENVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGVAEGSLPSSVPVEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRLDKQFNPFSVDRIDVVVATTLSITIISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFEKILMPELASLRIAVMEEGSKFLGHRIIPINALHSGYHHLCLRSESNMALTMPALFVFLEMKDYIPDTWADLTVALANPIKYFNAQDKKSVKLKGVTGSLPEKLFSGTPVASQSNGAPVSAGNGSTAPGTKATGEEATKEVTEPQTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQTQAAGCKLRPGKGSRKKRTLPCEETVVAPSEPHDRADPRVQELKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKTFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEERQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESVRAYFKDCFPTEAEDKPERSCEASEESCPQEPLVSKADTQESRL | |
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform b | |
|---|---|
| Refseq ID | NP_001277719 |
| Protein GI | 595763333 |
| UniProt ID | Q3V3V2 |
| mRNA ID | NM_001290790 |
| Length | 1158 |
| RefSeq Status | VALIDATED |
| MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQNQSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKENVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGVAEGSLPSSVPVEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRLDKQFNPFSVDRIDVVVATTLSITIISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFEKILMPELASLRIAVMEEGSKFLGHRIIPINALHSGYHHLCLRSESNMALTMPALFVFLEMKDYIPDTWADLTVALANPIKYFNAQDKKSVKLKGVTGSLPEKLFSGTPVASQSNGAPVSAGNGSTAPGTKATGEEATKEVTEPQTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQTQAAGCKLRPGKGSRKKRTLPCEETVVAPSEPHDRADPRVQELKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKTFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEERQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESVRAYFKDCFPTEAEDKPERSCEASEESCPQEPLVSKADTQESRL | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IDA:MGI | C | cytoplasm |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0004435 | IEA:UniProtKB-EC | F | phosphatidylinositol phospholipase C activity |
| GO:0004871 | IEA:UniProtKB-KW | F | signal transducer activity |
| GO:0035556 | IEA:InterPro | P | intracellular signal transduction |
| GO:0016042 | IEA:UniProtKB-KW | P | lipid catabolic process |
| GO:0050913 | IMP:MGI | P | sensory perception of bitter taste |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR028403 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 |
| IPR000008 | C2 domain |
| IPR011992 | EF-hand domain pair |
| IPR016280 | Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta |
| IPR001192 | Phosphoinositide phospholipase C family |
| IPR000909 | Phospholipase C, phosphatidylinositol-specific , X domain |
| IPR001711 | Phospholipase C, phosphatidylinositol-specific, Y domain |
| IPR015359 | Phospholipase C, phosphoinositol-specific, EF-hand-like |
| IPR014815 | PLC-beta, C-terminal |
| IPR017946 | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=A3KGF7-1; Sequence=Displayed; Name=2; IsoId=A3KGF7-2; Sequence=VSP_026982, VSP_026985, VSP_026986; Name=3; IsoId=A3KGF7-3; Sequence=VSP_026985, VSP_026986; Name=4; IsoId=A3KGF7-4; Sequence=VSP_026981, VSP_026983, VSP_026984; |
| Catalytic Activity | 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. |
| Cofactor | Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000250}; |
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This protein may be involved in the transduction of bitter taste stimuli (By similarity). {ECO:0000250}. |
| Miscellaneous | The receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha subunit, alpha- 16. {ECO:0000250}. |
| Similarity | Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}. |
| Similarity | Contains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}. |
| Similarity | Contains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}. |
| Subunit | Interacts with RAC1. {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006593 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 61676179 | RefSeq | NP_808236 | 1181 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform a |
| 595763333 | RefSeq | NP_001277719 | 1158 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform b |
Identical Sequences to LMP006593 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:61676179 | GenBank | AAI56753.1 | 1181 | Phospholipase C, beta 2 [synthetic construct] |
| GI:61676179 | SwissProt | A3KGF7.1 | 1181 | RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; AltName: Full=Phosphoinositide phospholipase C-beta-2; AltName: Full=Phospholipase C-beta-2; Short=PLC-beta-2 [Mus musculus] |
Related Sequences to LMP006593 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:61676179 | EMBL | CBF74725.1 | 1183 | unnamed protein product [Rattus norvegicus] |
| GI:61676179 | EMBL | CBF62962.1 | 1183 | unnamed protein product [Rattus norvegicus] |
| GI:595763333 | GenBank | EDL27914.1 | 1181 | phospholipase C, beta 2, isoform CRA_a [Mus musculus] |
| GI:595763333 | GenBank | AAI56753.1 | 1181 | Phospholipase C, beta 2 [synthetic construct] |
| GI:595763333 | GenBank | AAI45250.1 | 1158 | Plcb2 protein [Mus musculus] |
| GI:61676179 | GenBank | AGX64213.1 | 1183 | Sequence 28536 from patent US 8541208 |
| GI:595763333 | RefSeq | NP_808236.2 | 1181 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform a [Mus musculus] |
| GI:595763333 | RefSeq | XP_006498995.1 | 1126 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2 [Mus musculus] |
| GI:61676179 | RefSeq | XP_006498995.1 | 1126 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2 [Mus musculus] |
| GI:61676179 | RefSeq | NP_001277719.1 | 1158 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform b [Mus musculus] |
| GI:61676179 | SwissProt | O89040.1 | 1183 | RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; AltName: Full=Phosphoinositide phospholipase C-beta-2; AltName: Full=Phospholipase C-beta-2; Short=PLC-beta-2 [Rattus norvegicus] |
| GI:595763333 | SwissProt | A3KGF7.1 | 1181 | RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; AltName: Full=Phosphoinositide phospholipase C-beta-2; AltName: Full=Phospholipase C-beta-2; Short=PLC-beta-2 [Mus musculus] |