Gene/Proteome Database (LMPD)

LMPD ID
LMP006596
Gene ID
67452
Species
Mus musculus (Mouse)
Gene Name
patatin-like phospholipase domain containing 8
Gene Symbol
Pnpla8
Synonyms
1200006O19Rik; AI467579; Ipla2(gamma)
Alternate Names
calcium-independent phospholipase A2-gamma; iPLA2 gamma; iPLA2-gamma; patatin-like phospholipase domain-containing protein 8; intracellular membrane-associated calcium-independent phospholipase A2 gamma
Chromosome
12
Map Location
12 B3|12
EC Number
3.1.1.5

Proteins

calcium-independent phospholipase A2-gamma
Refseq ID NP_080440
Protein GI 118130807
UniProt ID Q8K1N1
mRNA ID NM_026164
Length 776
RefSeq Status VALIDATED
MSINLTLDIYIYFLNNARSLCGKQRSKQLHFVCSKQYWRMNHVNVHREFHTSKKSCKWNRSEAHCSKHWHSPSNHGLHFGIVRLSTSAPKGLTKVSIHMSRIKSTLNSVSKAIFGSQNEMVTRLAQFKPSSRILRKVSDKGWLKQKNVKQAVESLKNYSDKSAGKNSLAEQKSYFADKEEDSGKHSLFHYTYGITTRFGESFSVLANHINSYFKSKGKMSQTKEDKQLQDKPDLEERKSSSPGPDTVADRPDSESPLEVKDKLSSPTQMPEAHPVSAKQSIANFLSRPTEGVQALVGGYIGGLVPKLKSDPKSPPEEQEVSAKTEQAVNKDKKAEEKKRVLLQQEKIIARVSIDNRTRALVQALRRTADPKLCITRVEELTFHLLEFPEGKGVAIKEKIIPYLLRLRQVKDETLQAAVREILALIGYVDPVKGRGIRILTIDGGGTRGVVALQTLRKLVELTQKPIHQLFDYICGVSTGAILAFMLGLFHMPLDECEELYRKLGSDVFTQNVIVGTVKMSWSHAFYDSNTWEKILKDRIGSALMIETARNPACPKVAAISTIVNRGQTPKAFVFRNYGHFPGTNSHYLGGCQYKMWQAIRASSAAPGYFAEYALGSDLHQDGGLLLNNPSALALHECKCIWPDTPLECIVSLGTGRYESDVRNTSTYTSLKTKLSNVISSATDTEEVHIMLDGLLPSDTYFRFNPVICENIPLDESRDEKLDQLQLEGMKYIERNDQKMKKVAKILSQEKTTLQKINDWIKLKSDMYEGLPFFSKL

Gene Information

Entrez Gene ID
67452
Gene Name
patatin-like phospholipase domain containing 8
Gene Symbol
Pnpla8
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005622 ISS:UniProtKB C intracellular
GO:0005778 ISS:UniProtKB C peroxisomal membrane
GO:0047499 ISS:UniProtKB F calcium-independent phospholipase A2 activity
GO:0004622 IEA:UniProtKB-EC F lysophospholipase activity
GO:0019369 IEA:Ensembl P arachidonic acid metabolic process
GO:0050482 IEA:Ensembl P arachidonic acid secretion
GO:0008219 IEA:Ensembl P cell death
GO:0006631 ISS:UniProtKB P fatty acid metabolic process
GO:0043651 IEA:Ensembl P linoleic acid metabolic process
GO:0034638 IEA:Ensembl P phosphatidylcholine catabolic process
GO:0046338 IEA:Ensembl P phosphatidylethanolamine catabolic process
GO:0001516 IEA:Ensembl P prostaglandin biosynthetic process

REACTOME Pathway Links

REACTOME Pathway ID Description
5893974 Acyl chain remodelling of PC
5893981 Acyl chain remodelling of PE
5892983 Glycerophospholipid biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR002641 Patatin/Phospholipase A2-related

UniProt Annotations

Entry Information

Gene Name
patatin-like phospholipase domain containing 8
Protein Entry
PLPL8_MOUSE
UniProt ID
Q8K1N1
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
Enzyme Regulation Inhibited by E-6-bromomethylene-3-1- naphthalenyl-2H-tetrahydropyran-2-one (BEL). {ECO:0000250}.
Function Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids (By similarity). {ECO:0000250}.
Sequence Caution Sequence=AAH19364.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB23417.1; Type=Erroneous termination; Positions=777; Note=Translated as stop.; Evidence={ECO:0000305};
Similarity Contains 1 patatin domain. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006596 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
118130807 RefSeq NP_080440 776 calcium-independent phospholipase A2-gamma

Identical Sequences to LMP006596 proteins

Reference Database Accession Length Protein Name
GI:118130807 DBBJ BAE37236.1 776 unnamed protein product [Mus musculus]
GI:118130807 DBBJ BAE26645.1 776 unnamed protein product [Mus musculus]
GI:118130807 GenBank AAI27057.1 776 Patatin-like phospholipase domain containing 8 [Mus musculus]
GI:118130807 GenBank AEU43359.1 776 Sequence 108 from patent US 8052970
GI:118130807 GenBank AEU43380.1 776 Sequence 129 from patent US 8052970
GI:118130807 SwissProt Q8K1N1.1 776 RecName: Full=Calcium-independent phospholipase A2-gamma; AltName: Full=Intracellular membrane-associated calcium-independent phospholipase A2 gamma; Short=iPLA2-gamma; AltName: Full=Patatin-like phospholipase domain-containing protein 8 [Mus musculus]

Related Sequences to LMP006596 proteins

Reference Database Accession Length Protein Name
GI:118130807 DBBJ BAB23417.1 803 unnamed protein product [Mus musculus]
GI:118130807 DBBJ BAE40365.1 776 unnamed protein product [Mus musculus]
GI:118130807 GenBank EDL36811.1 777 patatin-like phospholipase domain containing 8, isoform CRA_a, partial [Mus musculus]
GI:118130807 GenBank EDM03350.1 776 similar to intracellular membrane-associated calcium-independent phospholipase A2 gamma (predicted), isoform CRA_b [Rattus norvegicus]
GI:118130807 GenBank AEU43410.1 776 Sequence 159 from patent US 8052970
GI:118130807 GenBank AEU43503.1 803 Sequence 252 from patent US 8052970