Gene/Proteome Database (LMPD)

LMPD ID
LMP006598
Gene ID
241274
Species
Mus musculus (Mouse)
Gene Name
patatin-like phospholipase domain containing 7
Gene Symbol
Pnpla7
Synonyms
BC027342; E430013P11Rik; Nre
Alternate Names
patatin-like phospholipase domain-containing protein 7; NTE-related esterase; neuropathy target esterase-related esterase
Chromosome
2
Map Location
2 A3|2
EC Number
3.1.1.-

Proteins

patatin-like phospholipase domain-containing protein 7
Refseq ID NP_666363
Protein GI 225007615
UniProt ID A2AJ88
mRNA ID NM_146251
Length 1352
RefSeq Status VALIDATED
MQNEEDACLEAGYCLGTTLSSWRLHFMEEQSQSTMLMGIGIGALLTLAFVGITFFFVYRRVRRLRRAEPTPQYRFRKRDKVMFYGRKIMRKVTTLPHTLVGNTSAPRQRVRKRTKVLSLAKRILRFKKEYPTLQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGEHVFQPGEPDISIYVVQDGRLEVCIQDADGTEVVVKEVLPGDSVHSLLSILDVITGHTAPYKTVSARAAVSSTVLWLPAAAFQGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNPESQAIPLLSVASVAGRAKRQMSYGPEEQLERSLRPSEFSSSDHGSSCVTVSGPLLKRSCSVPLPSNHGEVDELRQSQGSGSNTSAFQESHEGATSDLGMAYNRARILPHSDEQLGNSLASKSKKSVVAETPSAIFHYSENFRDETGACGKTDAIFRAATKDLLTLMKLDDPSLLDGRVAFLHVPAGTLVSKQGDQDVNILFVVSGMLHVYQQKIDSLEDTCLFLTHPGEMVGQLAVLTGEPLMFTIRANRDCSFLSISKAHFYEIMRKRPDVVLGVAHTVVKRMSSFVRQIDFALDWMEVEAGRAIYRQGDKSDCTYIVLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVETLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGSATGHQLGFNTASSKWDLGNPPGNLSTVAALPASEDVPLTAFALELQHALSAIGPVLLLTSDNIKQRLGSAALDSIHEYRLSSWLGQQEDIHRIVLYQADGTLTPWTQRCIRQADCILIVGLGEQEPAVGELEQMLESTAVRAQKQLILLHKEDGPVPSRTVEWLNMRSWCSGHLHLCCPRRVFSKRSLPKLVEMYTRVFQRPPDRHSDFSRLARMLTGNAIALVLGGGGARGCAQVGILRALAECGVPVDIIGGTSIGAFMGALFAEERSYSQTRIRAKQWAEGMTSMMKTILDLTYPITSMFSGTGFNSSISNIFKDRQIEDLWLPYFAITTDITASAMRVHTDGSLWRYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEMVKNSDYCEYLRPPIDSYRTLDFGKFDEICEVGYQHGRTVFDIWVRSGVLEKMLQDQQGTSKRKDCGVFTCPNSSFTDLAEIVSRIEPAKVAAVDDESDYQTEYEEELPAIPKETYADFQSTGIELDSDSEYEPSMLQGPPSLTSPEQSQDSFPWLPNQDDQGPRLEHPS

Gene Information

Entrez Gene ID
241274
Gene Name
patatin-like phospholipase domain containing 7
Gene Symbol
Pnpla7
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:MGI C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005764 IEA:UniProtKB-KW C lysosome
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0004622 IDA:MGI F lysophospholipase activity
GO:0006629 IEA:InterPro P lipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00564 Glycerophospholipid metabolism
mmu00564 Glycerophospholipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR000595 Cyclic nucleotide-binding domain
IPR018490 Cyclic nucleotide-binding-like
IPR002641 Patatin/Phospholipase A2-related
IPR014710 RmlC-like jelly roll fold

UniProt Annotations

Entry Information

Gene Name
patatin-like phospholipase domain containing 7
Protein Entry
PLPL7_MOUSE
UniProt ID
A2AJ88
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=A2AJ88-1; Sequence=Displayed; Name=2; Synonyms=mNREV1; IsoId=A2AJ88-2; Sequence=VSP_026506, VSP_026507; Name=3; Synonyms=mNREV2; IsoId=A2AJ88-3; Sequence=VSP_053967, VSP_053968;
Caution It is uncertain whether Met-1 or Met-27 is the initiator. {ECO:0000305}.
Function Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy (By similarity). Isoform 1 and isoform 2 have equal enzyme activity. Isoform 3 has no enzyme activity. {ECO:0000250, ECO:0000269|PubMed:22326266}.
Induction By nutritional conditions. Expression of isoform 3 is switched to the expression of isoform 2 during fasting. In the examined tissues, high expression levels of isoform 3 are detected in fed status, but expression is significantly decreased to about one fourth in fasted status. Isoform 2 expression levels are down- regulated under fed status and are up-regulated in fasted status. Isoform 1 expression levels are not affected by fasting. {ECO:0000269|PubMed:22326266}.
Sequence Caution Sequence=AAH27342.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH27342.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAI41366.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI41367.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC40302.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAE28519.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAE41783.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Similarity Belongs to the NTE family. {ECO:0000305}.
Similarity Contains 1 patatin domain. {ECO:0000305}.
Similarity Contains 3 cyclic nucleotide-binding domains. {ECO:0000255|PROSITE-ProRule:PRU00060}.
Subcellular Location Isoform 1: Endoplasmic reticulum membrane; Single-pass membrane protein.
Subcellular Location Isoform 2: Endoplasmic reticulum membrane; Single-pass membrane protein.
Subcellular Location Isoform 3: Endoplasmic reticulum membrane; Single-pass membrane protein.
Subcellular Location Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Mitochondrion membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Found in the nuclear, mitochondrial, lysosomal, and microsomal fractions. {ECO:0000250}.
Tissue Specificity Isoform 1, isoform 2 and isoform 3 are expressed in white adipose tissue, cardiac muscle, skeletal muscle, and testis. {ECO:0000269|PubMed:22326266}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006598 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
225007615 RefSeq NP_666363 1352 patatin-like phospholipase domain-containing protein 7

Identical Sequences to LMP006598 proteins

Reference Database Accession Length Protein Name
GI:225007615 SwissProt A2AJ88.1 1352 RecName: Full=Patatin-like phospholipase domain-containing protein 7; AltName: Full=Neuropathy target esterase-related esterase; Short=NRE; Short=NTE-related esterase [Mus musculus]

Related Sequences to LMP006598 proteins

Reference Database Accession Length Protein Name
GI:225007615 DBBJ BAE28519.1 1427 unnamed protein product, partial [Mus musculus]
GI:225007615 DBBJ BAE41783.1 1417 unnamed protein product, partial [Mus musculus]
GI:225007615 GenBank EDL08189.1 1418 patatin-like phospholipase domain containing 7, isoform CRA_a, partial [Mus musculus]
GI:225007615 RefSeq XP_006498077.1 1376 PREDICTED: patatin-like phospholipase domain containing 7 isoform X1 [Mus musculus]
GI:225007615 RefSeq XP_006498078.1 1373 PREDICTED: patatin-like phospholipase domain containing 7 isoform X2 [Mus musculus]
GI:225007615 RefSeq XP_006498079.1 1355 PREDICTED: patatin-like phospholipase domain containing 7 isoform X3 [Mus musculus]