Gene/Proteome Database (LMPD)
LMPD ID
LMP006600
Gene ID
Species
Mus musculus (Mouse)
Gene Name
phospholipase C, eta 2
Gene Symbol
Synonyms
A930027K05Rik; PLCeta2; Plc-eta2; Plcl4
Alternate Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2; phospholipase C-like protein 4; phosphoinositide phospholipase C-eta-2; phosphoinositide phospholipase C-like 4
Chromosome
4
Map Location
4 E2|4
EC Number
3.1.4.11
Proteins
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform a | |
|---|---|
| Refseq ID | NP_780765 |
| Protein GI | 121583637 |
| UniProt ID | Q6PAS6 |
| mRNA ID | NM_175556 |
| Length | 1238 |
| RefSeq Status | VALIDATED |
| MGGLAWGPSRAAGSSWVNASGTWEQPLRGFSGLQGGRRRGRGEKGIPEEPLCQLTPQLGLSLRVPFGLGDYGLDMPGPQPSAASQTTGAVACLAEVLLWVGGSVVVSPRWQLSLVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRGKAPGGEATEERTLAQVRSPNAPEGPGPAGMAATCMKCVVGSCAGMDVEGLQREQQPSPGPAGSHMAISHQPRARVDSLGGPCCSPSPRATPGRSKEAPKGPRARRQGPGGGSVSSDSSSPDSPGSPKVAPCQPEGAHRQQGALQGEMNALFVQKLEEIRSHSPMFSTVRD | |
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform b | |
|---|---|
| Refseq ID | NP_001106831 |
| Protein GI | 164565357 |
| UniProt ID | A2AP18 |
| mRNA ID | NM_001113360 |
| Length | 1501 |
| RefSeq Status | VALIDATED |
| MGGLAWGPSRAAGSSWVNASGTWEQPLRGFSGLQGGRRRGRGEKGIPEEPLCQLTPQLGLSLRVPFGLGDYGLDMPGPQPSAASQTTGAVACLAEVLLWVGGSVVVSPRWQLSLVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRDTRLFPLQRPISPLCSLEPIAEEPALGPGLPLQAAAPTGPSQEGSQCPVGLGAKVTSSQQTSLGAFGTLQLRIGGGRENEEPPLRPHNGGISSGPREGTSGRQTDSKSRSRVPGHLPVVRRAKSEGQVLSELSPTPAVYSDATGTDRLWQRLEPGSHRDSVSSSSSMSSNDTVIDLSLPSLGLCRSRESIPGVSLGRLTSRPCLASAARPDLPPVTKSKSNPNLRVAGGLPTAPDELQPRPLAPRLTGHHPRPPWHHLTLVGLRDCPVSAKSKSLGDLTADDFAPSFQGSTSSLSCGLGSLGVAHQVLEPGIRRDALTEQLRWLTGFQQAGDITSPTSLGPAGDGSVGGPSFLRRSSSRSQSRVRAIASRARQAQERQQRLRGQDSRGPPEEERGTPEGACSVGHEGCVDVPMPAKGAPEQVCGAADGQLLLRL | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IEA:UniProtKB-KW | C | cytoplasm |
| GO:0005886 | IDA:MGI | C | plasma membrane |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0004435 | IEA:UniProtKB-EC | F | phosphatidylinositol phospholipase C activity |
| GO:0004629 | IDA:MGI | F | phospholipase C activity |
| GO:0004871 | IEA:UniProtKB-KW | F | signal transducer activity |
| GO:0035556 | IEA:InterPro | P | intracellular signal transduction |
| GO:0016042 | IEA:UniProtKB-KW | P | lipid catabolic process |
| GO:0046488 | IDA:MGI | P | phosphatidylinositol metabolic process |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-6351 | D-myo-inositol (1,4,5)-trisphosphate biosynthesis |
| PWY3DJ-219 | PIP metabolism |
REACTOME Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR028393 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 |
| IPR000008 | C2 domain |
| IPR018247 | EF-Hand 1, calcium-binding site |
| IPR002048 | EF-hand domain |
| IPR011992 | EF-hand domain pair |
| IPR017946 | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain |
| IPR001192 | Phosphoinositide phospholipase C family |
| IPR000909 | Phospholipase C, phosphatidylinositol-specific , X domain |
| IPR001711 | Phospholipase C, phosphatidylinositol-specific, Y domain |
| IPR015359 | Phospholipase C, phosphoinositol-specific, EF-hand-like |
| IPR001849 | Pleckstrin homology domain |
| IPR011993 | Pleckstrin homology-like domain |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=A2AP18-1; Sequence=Displayed; Name=2; IsoId=A2AP18-2; Sequence=VSP_029082, VSP_029083; Name=3; IsoId=A2AP18-3; Sequence=VSP_029081, VSP_029084; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay..; Name=4; IsoId=A2AP18-4; Sequence=VSP_029075, VSP_029077; Name=5; IsoId=A2AP18-5; Sequence=VSP_029076, VSP_029078, VSP_029079; |
| Catalytic Activity | 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. |
| Cofactor | Name=Ca(2+); Xref=ChEBI:CHEBI:29108; |
| Developmental Stage | Expressed at 2 weeks after birth but barely detected 1 week after birth. Increased expression during brain development. {ECO:0000269|PubMed:15899900}. |
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain. {ECO:0000269|PubMed:15899900, ECO:0000269|PubMed:16107206}. |
| Sequence Caution | Sequence=BAC32005.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC32005.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BAC37371.1; Type=Erroneous termination; Positions=433; Note=Translated as Tyr.; Evidence={ECO:0000305}; Sequence=CAO78007.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAO78129.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; |
| Similarity | Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}. |
| Similarity | Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}. |
| Similarity | Contains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}. |
| Similarity | Contains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}. |
| Similarity | Contains 2 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15899900}. Cell membrane {ECO:0000269|PubMed:15899900}. Note=Localized predominantly at the plasma membrane. |
| Tissue Specificity | Specifically detected in the brain, with higher level in cerebral cortex, olfactory bulb and hippocampus (at protein level). Expressed in the pyramidal cells of the hippocampus, but also in eye and lung. {ECO:0000269|PubMed:15899900, ECO:0000269|PubMed:16107206}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006600 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 121583637 | RefSeq | NP_780765 | 1238 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform a |
| 164565357 | RefSeq | NP_001106831 | 1501 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform b |
Identical Sequences to LMP006600 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:164565357 | GenBank | ABA12210.1 | 1501 | phospholipase C-eta2 [Mus musculus] |
| GI:121583637 | GenBank | AAI48435.1 | 1238 | Phospholipase C, eta 2, partial [synthetic construct] |
| GI:121583637 | GenBank | AAI53019.1 | 1238 | Phospholipase C, eta 2 [synthetic construct] |
| GI:164565357 | SwissProt | A2AP18.2 | 1501 | RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2; AltName: Full=Phosphoinositide phospholipase C-eta-2; AltName: Full=Phosphoinositide phospholipase C-like 4; Short=PLC-L4; Short=Phospholipase C-like protein 4; AltName: Full=Phospholipase C-eta-2; Short=PLC-eta2 [Mus musculus] |
Related Sequences to LMP006600 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:121583637 | GenBank | AAY33831.1 | 1164 | PLCeta2 [Mus musculus] |
| GI:121583637 | GenBank | ERE82708.1 | 1750 | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-2 [Cricetulus griseus] |
| GI:121583637 | GenBank | ERE82711.1 | 1738 | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-2 [Cricetulus griseus] |
| GI:164565357 | RefSeq | XP_005079303.1 | 1515 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 [Mesocricetus auratus] |
| GI:164565357 | RefSeq | XP_005368707.1 | 1504 | PREDICTED: LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 [Microtus ochrogaster] |
| GI:164565357 | RefSeq | XP_006225723.1 | 1480 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X1 [Rattus norvegicus] |
| GI:121583637 | RefSeq | XP_006539002.1 | 1586 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X4 [Mus musculus] |
| GI:164565357 | RefSeq | XP_006539003.1 | 1571 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X5 [Mus musculus] |
| GI:121583637 | RefSeq | XP_006539005.1 | 1308 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X7 [Mus musculus] |
| GI:164565357 | RefSeq | XP_006992469.1 | 1506 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 [Peromyscus maniculatus bairdii] |
| GI:164565357 | RefSeq | XP_008762615.1 | 1506 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X2 [Rattus norvegicus] |
| GI:121583637 | RefSeq | XP_008762620.1 | 1243 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X7 [Rattus norvegicus] |