Gene/Proteome Database (LMPD)

LMPD ID
LMP006603
Gene ID
Species
Mus musculus (Mouse)
Gene Name
acyl-CoA synthetase medium-chain family member 2
Gene Symbol
Synonyms
AI315615; BC031140
Alternate Names
acyl-coenzyme A synthetase ACSM2, mitochondrial; butyrate--CoA ligase 2; butyryl coenzyme A synthetase 2; butyryl-coenzyme A synthetase 2; middle-chain acyl-CoA synthetase 2
Chromosome
7
Map Location
7 F2|7
EC Number
6.2.1.2

Proteins

acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 1
Refseq ID NP_001171448
Protein GI 295789125
UniProt ID Q8K0L3
mRNA ID NM_001177977
Length 600
RefSeq Status VALIDATED
MTTGSLDLPFVGSHRWIKWTTASLTMHHLWKIPRLFTLWGNEISCRTFHMNIKKLIPIQWGHQEAPAKFNFASDVIDHWASVEKAGKRSSGPALWWMNGSGKEIKWSFRELSEASKQTANVLSGACGLHRGDRVAVVLPRIPEWWLMILGCMRTGLVFMPGTIQMRSSDILYRLQASKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSENSREGWLNFKALLKEASTIHQCVETESRESAAIYFTSGTSGPPKMAEHSHCSLGIKAKMDAASWTGLSTSDIIWTISDTAWIMNILGAFLEPWVLGACIFVHLLPKFDSQTVLKVLSSYPINTLVGAPIIYRMLLQQDLSSYKFPHLHSCFSGGETLLPETLENWKAKTGLEIREIYGQTETGLICRVSRTMKVKPGYLGTAFAHYDVQVIDEQGNVLPPGKEGDIAIRVKPIWPIGMFSGYVDNPKKTQDNIRGDFWLMGDRGIKDPEGYFHFIGRSDDIINSSGYRIGPSEVENALMEHPAVSETAVISSPDPSRGEVVKAFVVLAPEFLSHDRDQLTKVLQEHVKSVTAPYKYPRKVEFVLDLPKTVTGKIERAKLRAKEWKTSGRA
acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 2
Refseq ID NP_001171449
Protein GI 295789127
UniProt ID Q8K0L3
mRNA ID NM_001177978
Length 580
RefSeq Status VALIDATED
MHHLWKIPRLFTLWGNEISCRTFHMNIKKLIPIQWGHQEAPAKFNFASDVIDHWASVEKAGKRSSGPALWWMNGSGKEIKWSFRELSEASKQTANVLSGACGLHRGDRVAVVLPRIPEWWLMILGCMRTGLVFMPGTIQMRSSDILYRLQASKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSENSREGWLNFKALLKEASTIHQCVETESRESAAIYFTSGTSGPPKMAEHSHCSLGIKAKMDAASWTGLSTSDIIWTISDTAWIMNILGAFLEPWVLGACIFVHLLPKFDSQTVLKVLSSYPINTLVGAPIIYRMLLQQDLSSYKFPHLHSCFSGGETLLPETLENWKAKTGLEIREIYGQTETGLICRVSRTMKVKPGYLGTAFAHYDVQVIDEQGNVLPPGKEGDIAIRVKPIWPIGMFSGYVDNPKKTQDNIRGDFWLMGDRGIKDPEGYFHFIGRSDDIINSSGAYFCRYRIGPSEVENALMEHPAVSETAVISSPDPSRGEVVKAFVVLAPEFLSHDRDQLTKVLQEHVKSVTAPYKYPRKVEFVLDLPKTVTGKIERAKLRAKEWKTSGRA
acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 3
Refseq ID NP_666309
Protein GI 22122743
UniProt ID Q8K0L3
mRNA ID NM_146197
Length 575
RefSeq Status VALIDATED
MHHLWKIPRLFTLWGNEISCRTFHMNIKKLIPIQWGHQEAPAKFNFASDVIDHWASVEKAGKRSSGPALWWMNGSGKEIKWSFRELSEASKQTANVLSGACGLHRGDRVAVVLPRIPEWWLMILGCMRTGLVFMPGTIQMRSSDILYRLQASKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSENSREGWLNFKALLKEASTIHQCVETESRESAAIYFTSGTSGPPKMAEHSHCSLGIKAKMDAASWTGLSTSDIIWTISDTAWIMNILGAFLEPWVLGACIFVHLLPKFDSQTVLKVLSSYPINTLVGAPIIYRMLLQQDLSSYKFPHLHSCFSGGETLLPETLENWKAKTGLEIREIYGQTETGLICRVSRTMKVKPGYLGTAFAHYDVQVIDEQGNVLPPGKEGDIAIRVKPIWPIGMFSGYVDNPKKTQDNIRGDFWLMGDRGIKDPEGYFHFIGRSDDIINSSGYRIGPSEVENALMEHPAVSETAVISSPDPSRGEVVKAFVVLAPEFLSHDRDQLTKVLQEHVKSVTAPYKYPRKVEFVLDLPKTVTGKIERAKLRAKEWKTSGRA
transit_peptide: 1..46 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q8K0L3.1) calculated_mol_wt: 5617 peptide sequence: MHHLWKIPRLFTLWGNEISCRTFHMNIKKLIPIQWGHQEAPAKFNF transit_peptide: 1..46 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q8K0L3.1) calculated_mol_wt: 5617 peptide sequence: MHHLWKIPRLFTLWGNEISCRTFHMNIKKLIPIQWGHQEAPAKFNF mat_peptide: 47..575 product: Acyl-coenzyme A synthetase ACSM2, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q8K0L3.1) calculated_mol_wt: 58671 peptide sequence: ASDVIDHWASVEKAGKRSSGPALWWMNGSGKEIKWSFRELSEASKQTANVLSGACGLHRGDRVAVVLPRIPEWWLMILGCMRTGLVFMPGTIQMRSSDILYRLQASKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSENSREGWLNFKALLKEASTIHQCVETESRESAAIYFTSGTSGPPKMAEHSHCSLGIKAKMDAASWTGLSTSDIIWTISDTAWIMNILGAFLEPWVLGACIFVHLLPKFDSQTVLKVLSSYPINTLVGAPIIYRMLLQQDLSSYKFPHLHSCFSGGETLLPETLENWKAKTGLEIREIYGQTETGLICRVSRTMKVKPGYLGTAFAHYDVQVIDEQGNVLPPGKEGDIAIRVKPIWPIGMFSGYVDNPKKTQDNIRGDFWLMGDRGIKDPEGYFHFIGRSDDIINSSGYRIGPSEVENALMEHPAVSETAVISSPDPSRGEVVKAFVVLAPEFLSHDRDQLTKVLQEHVKSVTAPYKYPRKVEFVLDLPKTVTGKIERAKLRAKEWKTSGRA

Gene Information

Entrez Gene ID
Gene Name
acyl-CoA synthetase medium-chain family member 2
Gene Symbol
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:MGI C mitochondrion
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0047760 IEA:UniProtKB-EC F butyrate-CoA ligase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00650 Butanoate metabolism
mmu01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5893231 Conjugation of benzoate with glycine
5893232 Conjugation of carboxylic acids

Domain Information

InterPro Annotations

Accession Description
IPR025110 AMP-binding enzyme C-terminal domain
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
acyl-CoA synthetase medium-chain family member 2
Protein Entry
ACSM2_MOUSE
UniProt ID
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8K0L3-1; Sequence=Displayed; Name=2; IsoId=Q8K0L3-2; Sequence=VSP_028393; Note=No experimental confirmation available.; Name=3; IsoId=Q8K0L3-3; Sequence=VSP_028394; Note=No experimental confirmation available.;
Catalytic Activity ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
Enzyme Regulation Activated by monovalent cations, such as potassium, rubidium or ammonium. {ECO:0000250}.
Function Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity). {ECO:0000250}.
Similarity Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular Location Mitochondrion matrix {ECO:0000250}.
Subunit Monomer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006603 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
295789125 RefSeq NP_001171448 600 acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 1
295789127 RefSeq NP_001171449 580 acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 2
22122743 RefSeq NP_666309 575 acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 3

Identical Sequences to LMP006603 proteins

Reference Database Accession Length Protein Name
GI:22122743 DBBJ BAE25526.1 575 unnamed protein product [Mus musculus]
GI:295789125 DBBJ BAE24490.1 600 unnamed protein product [Mus musculus]
GI:22122743 DBBJ BAE38146.1 575 unnamed protein product [Mus musculus]
GI:295789127 DBBJ BAE38163.1 580 unnamed protein product [Mus musculus]
GI:22122743 GenBank AAH31140.1 575 Acyl-CoA synthetase medium-chain family member 2 [Mus musculus]
GI:22122743 GenBank EDL17171.1 575 acyl-CoA synthetase medium-chain family member 2, isoform CRA_c [Mus musculus]
GI:22122743 SwissProt Q8K0L3.1 575 RecName: Full=Acyl-coenzyme A synthetase ACSM2, mitochondrial; AltName: Full=Acyl-CoA synthetase medium-chain family member 2; AltName: Full=Butyrate--CoA ligase 2; AltName: Full=Butyryl-coenzyme A synthetase 2; AltName: Full=Middle-chain acyl-CoA synthetase 2; Flags: Precursor [Mus musculus]

Related Sequences to LMP006603 proteins

Reference Database Accession Length Protein Name
GI:22122743 DBBJ BAB71542.1 575 unnamed protein product [Mus musculus]
GI:295789127 DBBJ BAE25526.1 575 unnamed protein product [Mus musculus]
GI:295789125 DBBJ BAE25526.1 575 unnamed protein product [Mus musculus]
GI:22122743 DBBJ BAE24490.1 600 unnamed protein product [Mus musculus]
GI:295789127 DBBJ BAE38146.1 575 unnamed protein product [Mus musculus]
GI:295789125 DBBJ BAE38146.1 575 unnamed protein product [Mus musculus]
GI:22122743 DBBJ BAE38163.1 580 unnamed protein product [Mus musculus]
GI:295789127 GenBank AAH31140.1 575 Acyl-CoA synthetase medium-chain family member 2 [Mus musculus]
GI:295789125 GenBank AAH31140.1 575 Acyl-CoA synthetase medium-chain family member 2 [Mus musculus]
GI:22122743 GenBank ABE15729.1 575 Sequence 3251 from patent US 6979557
GI:295789127 GenBank EDL17171.1 575 acyl-CoA synthetase medium-chain family member 2, isoform CRA_c [Mus musculus]
GI:295789125 GenBank EDL17171.1 575 acyl-CoA synthetase medium-chain family member 2, isoform CRA_c [Mus musculus]
GI:295789127 RefSeq NP_666309.1 575 acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 3 [Mus musculus]
GI:295789125 RefSeq NP_666309.1 575 acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 3 [Mus musculus]
GI:22122743 RefSeq NP_001171448.1 600 acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 1 [Mus musculus]
GI:22122743 RefSeq NP_001171449.1 580 acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 2 [Mus musculus]
GI:295789125 SwissProt Q8K0L3.1 575 RecName: Full=Acyl-coenzyme A synthetase ACSM2, mitochondrial; AltName: Full=Acyl-CoA synthetase medium-chain family member 2; AltName: Full=Butyrate--CoA ligase 2; AltName: Full=Butyryl-coenzyme A synthetase 2; AltName: Full=Middle-chain acyl-CoA synthetase 2; Flags: Precursor [Mus musculus]
GI:295789127 SwissProt Q8K0L3.1 575 RecName: Full=Acyl-coenzyme A synthetase ACSM2, mitochondrial; AltName: Full=Acyl-CoA synthetase medium-chain family member 2; AltName: Full=Butyrate--CoA ligase 2; AltName: Full=Butyryl-coenzyme A synthetase 2; AltName: Full=Middle-chain acyl-CoA synthetase 2; Flags: Precursor [Mus musculus]