Gene/Proteome Database (LMPD)
LMPD ID
LMP006603
Gene ID
Species
Mus musculus (Mouse)
Gene Name
acyl-CoA synthetase medium-chain family member 2
Gene Symbol
Synonyms
AI315615; BC031140
Alternate Names
acyl-coenzyme A synthetase ACSM2, mitochondrial; butyrate--CoA ligase 2; butyryl coenzyme A synthetase 2; butyryl-coenzyme A synthetase 2; middle-chain acyl-CoA synthetase 2
Chromosome
7
Map Location
7 F2|7
EC Number
6.2.1.2
Proteins
acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 1 | |
---|---|
Refseq ID | NP_001171448 |
Protein GI | 295789125 |
UniProt ID | Q8K0L3 |
mRNA ID | NM_001177977 |
Length | 600 |
RefSeq Status | VALIDATED |
MTTGSLDLPFVGSHRWIKWTTASLTMHHLWKIPRLFTLWGNEISCRTFHMNIKKLIPIQWGHQEAPAKFNFASDVIDHWASVEKAGKRSSGPALWWMNGSGKEIKWSFRELSEASKQTANVLSGACGLHRGDRVAVVLPRIPEWWLMILGCMRTGLVFMPGTIQMRSSDILYRLQASKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSENSREGWLNFKALLKEASTIHQCVETESRESAAIYFTSGTSGPPKMAEHSHCSLGIKAKMDAASWTGLSTSDIIWTISDTAWIMNILGAFLEPWVLGACIFVHLLPKFDSQTVLKVLSSYPINTLVGAPIIYRMLLQQDLSSYKFPHLHSCFSGGETLLPETLENWKAKTGLEIREIYGQTETGLICRVSRTMKVKPGYLGTAFAHYDVQVIDEQGNVLPPGKEGDIAIRVKPIWPIGMFSGYVDNPKKTQDNIRGDFWLMGDRGIKDPEGYFHFIGRSDDIINSSGYRIGPSEVENALMEHPAVSETAVISSPDPSRGEVVKAFVVLAPEFLSHDRDQLTKVLQEHVKSVTAPYKYPRKVEFVLDLPKTVTGKIERAKLRAKEWKTSGRA |
acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 2 | |
---|---|
Refseq ID | NP_001171449 |
Protein GI | 295789127 |
UniProt ID | Q8K0L3 |
mRNA ID | NM_001177978 |
Length | 580 |
RefSeq Status | VALIDATED |
MHHLWKIPRLFTLWGNEISCRTFHMNIKKLIPIQWGHQEAPAKFNFASDVIDHWASVEKAGKRSSGPALWWMNGSGKEIKWSFRELSEASKQTANVLSGACGLHRGDRVAVVLPRIPEWWLMILGCMRTGLVFMPGTIQMRSSDILYRLQASKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSENSREGWLNFKALLKEASTIHQCVETESRESAAIYFTSGTSGPPKMAEHSHCSLGIKAKMDAASWTGLSTSDIIWTISDTAWIMNILGAFLEPWVLGACIFVHLLPKFDSQTVLKVLSSYPINTLVGAPIIYRMLLQQDLSSYKFPHLHSCFSGGETLLPETLENWKAKTGLEIREIYGQTETGLICRVSRTMKVKPGYLGTAFAHYDVQVIDEQGNVLPPGKEGDIAIRVKPIWPIGMFSGYVDNPKKTQDNIRGDFWLMGDRGIKDPEGYFHFIGRSDDIINSSGAYFCRYRIGPSEVENALMEHPAVSETAVISSPDPSRGEVVKAFVVLAPEFLSHDRDQLTKVLQEHVKSVTAPYKYPRKVEFVLDLPKTVTGKIERAKLRAKEWKTSGRA |
acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 3 | |
---|---|
Refseq ID | NP_666309 |
Protein GI | 22122743 |
UniProt ID | Q8K0L3 |
mRNA ID | NM_146197 |
Length | 575 |
RefSeq Status | VALIDATED |
MHHLWKIPRLFTLWGNEISCRTFHMNIKKLIPIQWGHQEAPAKFNFASDVIDHWASVEKAGKRSSGPALWWMNGSGKEIKWSFRELSEASKQTANVLSGACGLHRGDRVAVVLPRIPEWWLMILGCMRTGLVFMPGTIQMRSSDILYRLQASKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSENSREGWLNFKALLKEASTIHQCVETESRESAAIYFTSGTSGPPKMAEHSHCSLGIKAKMDAASWTGLSTSDIIWTISDTAWIMNILGAFLEPWVLGACIFVHLLPKFDSQTVLKVLSSYPINTLVGAPIIYRMLLQQDLSSYKFPHLHSCFSGGETLLPETLENWKAKTGLEIREIYGQTETGLICRVSRTMKVKPGYLGTAFAHYDVQVIDEQGNVLPPGKEGDIAIRVKPIWPIGMFSGYVDNPKKTQDNIRGDFWLMGDRGIKDPEGYFHFIGRSDDIINSSGYRIGPSEVENALMEHPAVSETAVISSPDPSRGEVVKAFVVLAPEFLSHDRDQLTKVLQEHVKSVTAPYKYPRKVEFVLDLPKTVTGKIERAKLRAKEWKTSGRA | |
transit_peptide: 1..46 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q8K0L3.1) calculated_mol_wt: 5617 peptide sequence: MHHLWKIPRLFTLWGNEISCRTFHMNIKKLIPIQWGHQEAPAKFNF transit_peptide: 1..46 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q8K0L3.1) calculated_mol_wt: 5617 peptide sequence: MHHLWKIPRLFTLWGNEISCRTFHMNIKKLIPIQWGHQEAPAKFNF mat_peptide: 47..575 product: Acyl-coenzyme A synthetase ACSM2, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q8K0L3.1) calculated_mol_wt: 58671 peptide sequence: ASDVIDHWASVEKAGKRSSGPALWWMNGSGKEIKWSFRELSEASKQTANVLSGACGLHRGDRVAVVLPRIPEWWLMILGCMRTGLVFMPGTIQMRSSDILYRLQASKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSENSREGWLNFKALLKEASTIHQCVETESRESAAIYFTSGTSGPPKMAEHSHCSLGIKAKMDAASWTGLSTSDIIWTISDTAWIMNILGAFLEPWVLGACIFVHLLPKFDSQTVLKVLSSYPINTLVGAPIIYRMLLQQDLSSYKFPHLHSCFSGGETLLPETLENWKAKTGLEIREIYGQTETGLICRVSRTMKVKPGYLGTAFAHYDVQVIDEQGNVLPPGKEGDIAIRVKPIWPIGMFSGYVDNPKKTQDNIRGDFWLMGDRGIKDPEGYFHFIGRSDDIINSSGYRIGPSEVENALMEHPAVSETAVISSPDPSRGEVVKAFVVLAPEFLSHDRDQLTKVLQEHVKSVTAPYKYPRKVEFVLDLPKTVTGKIERAKLRAKEWKTSGRA |
Gene Information
Entrez Gene ID
Gene Name
acyl-CoA synthetase medium-chain family member 2
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0005739 | IDA:MGI | C | mitochondrion |
GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
GO:0047760 | IEA:UniProtKB-EC | F | butyrate-CoA ligase activity |
GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
GO:0006631 | IEA:UniProtKB-KW | P | fatty acid metabolic process |
KEGG Pathway Links
REACTOME Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
acyl-CoA synthetase medium-chain family member 2
Protein Entry
ACSM2_MOUSE
UniProt ID
Species
Mouse
Comments
Comment Type | Description |
---|---|
Alternative Products | Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8K0L3-1; Sequence=Displayed; Name=2; IsoId=Q8K0L3-2; Sequence=VSP_028393; Note=No experimental confirmation available.; Name=3; IsoId=Q8K0L3-3; Sequence=VSP_028394; Note=No experimental confirmation available.; |
Catalytic Activity | ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA. |
Cofactor | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; |
Enzyme Regulation | Activated by monovalent cations, such as potassium, rubidium or ammonium. {ECO:0000250}. |
Function | Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity). {ECO:0000250}. |
Similarity | Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}. |
Subcellular Location | Mitochondrion matrix {ECO:0000250}. |
Subunit | Monomer. {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006603 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
295789125 | RefSeq | NP_001171448 | 600 | acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 1 |
295789127 | RefSeq | NP_001171449 | 580 | acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 2 |
22122743 | RefSeq | NP_666309 | 575 | acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 3 |
Identical Sequences to LMP006603 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:22122743 | DBBJ | BAE25526.1 | 575 | unnamed protein product [Mus musculus] |
GI:295789125 | DBBJ | BAE24490.1 | 600 | unnamed protein product [Mus musculus] |
GI:22122743 | DBBJ | BAE38146.1 | 575 | unnamed protein product [Mus musculus] |
GI:295789127 | DBBJ | BAE38163.1 | 580 | unnamed protein product [Mus musculus] |
GI:22122743 | GenBank | AAH31140.1 | 575 | Acyl-CoA synthetase medium-chain family member 2 [Mus musculus] |
GI:22122743 | GenBank | EDL17171.1 | 575 | acyl-CoA synthetase medium-chain family member 2, isoform CRA_c [Mus musculus] |
GI:22122743 | SwissProt | Q8K0L3.1 | 575 | RecName: Full=Acyl-coenzyme A synthetase ACSM2, mitochondrial; AltName: Full=Acyl-CoA synthetase medium-chain family member 2; AltName: Full=Butyrate--CoA ligase 2; AltName: Full=Butyryl-coenzyme A synthetase 2; AltName: Full=Middle-chain acyl-CoA synthetase 2; Flags: Precursor [Mus musculus] |
Related Sequences to LMP006603 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:22122743 | DBBJ | BAB71542.1 | 575 | unnamed protein product [Mus musculus] |
GI:295789127 | DBBJ | BAE25526.1 | 575 | unnamed protein product [Mus musculus] |
GI:295789125 | DBBJ | BAE25526.1 | 575 | unnamed protein product [Mus musculus] |
GI:22122743 | DBBJ | BAE24490.1 | 600 | unnamed protein product [Mus musculus] |
GI:295789127 | DBBJ | BAE38146.1 | 575 | unnamed protein product [Mus musculus] |
GI:295789125 | DBBJ | BAE38146.1 | 575 | unnamed protein product [Mus musculus] |
GI:22122743 | DBBJ | BAE38163.1 | 580 | unnamed protein product [Mus musculus] |
GI:295789127 | GenBank | AAH31140.1 | 575 | Acyl-CoA synthetase medium-chain family member 2 [Mus musculus] |
GI:295789125 | GenBank | AAH31140.1 | 575 | Acyl-CoA synthetase medium-chain family member 2 [Mus musculus] |
GI:22122743 | GenBank | ABE15729.1 | 575 | Sequence 3251 from patent US 6979557 |
GI:295789127 | GenBank | EDL17171.1 | 575 | acyl-CoA synthetase medium-chain family member 2, isoform CRA_c [Mus musculus] |
GI:295789125 | GenBank | EDL17171.1 | 575 | acyl-CoA synthetase medium-chain family member 2, isoform CRA_c [Mus musculus] |
GI:295789127 | RefSeq | NP_666309.1 | 575 | acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 3 [Mus musculus] |
GI:295789125 | RefSeq | NP_666309.1 | 575 | acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 3 [Mus musculus] |
GI:22122743 | RefSeq | NP_001171448.1 | 600 | acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 1 [Mus musculus] |
GI:22122743 | RefSeq | NP_001171449.1 | 580 | acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 2 [Mus musculus] |
GI:295789125 | SwissProt | Q8K0L3.1 | 575 | RecName: Full=Acyl-coenzyme A synthetase ACSM2, mitochondrial; AltName: Full=Acyl-CoA synthetase medium-chain family member 2; AltName: Full=Butyrate--CoA ligase 2; AltName: Full=Butyryl-coenzyme A synthetase 2; AltName: Full=Middle-chain acyl-CoA synthetase 2; Flags: Precursor [Mus musculus] |
GI:295789127 | SwissProt | Q8K0L3.1 | 575 | RecName: Full=Acyl-coenzyme A synthetase ACSM2, mitochondrial; AltName: Full=Acyl-CoA synthetase medium-chain family member 2; AltName: Full=Butyrate--CoA ligase 2; AltName: Full=Butyryl-coenzyme A synthetase 2; AltName: Full=Middle-chain acyl-CoA synthetase 2; Flags: Precursor [Mus musculus] |