Gene/Proteome Database (LMPD)

LMPD ID
LMP006610
Gene ID
76303
Species
Mus musculus (Mouse)
Gene Name
oxysterol binding protein
Gene Symbol
Osbp
Synonyms
1110018F06Rik; AW559088; mKIAA4220
Alternate Names
oxysterol-binding protein 1
Chromosome
19
Map Location
19 A|19 8.58 cM

Proteins

oxysterol-binding protein 1
Refseq ID NP_001028346
Protein GI 133504509
UniProt ID Q3B7Z2
mRNA ID NM_001033174
Length 805
RefSeq Status VALIDATED
MAATELRGVVGPGPAAIAAPGGGGAGPPAVGGGGGRGDAGPGPGVAAATAATAGGPGPGAGGVAAGGPGSAPPAAGSGGSGAGGSGSAREGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATANITVEDSCNFIISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDDSGDEESVSQTDKTELQSTLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLKLPAESNEKIKQVNERATLFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLERAFRGATVLPANPPGSAGSGKDQCCSGKGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISGASSDVSLDEQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSICEQVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHSTGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMDCFKVQAASGENGGDARQRGHEAEDSRVMLWKRNPLPKNAENMYYFSELALTLNAWEGGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAAKATEDGTPHDPYKALWFERKKDPVTRELTHIYSGEYWECKEKQDWGSCPDIF

Gene Information

Entrez Gene ID
76303
Gene Name
oxysterol binding protein
Gene Symbol
Osbp
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030054 IEA:Ensembl C cell junction
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0005730 IEA:Ensembl C nucleolus
GO:0008289 IEA:UniProtKB-KW F lipid binding
GO:0006869 IEA:UniProtKB-KW P lipid transport

REACTOME Pathway Links

REACTOME Pathway ID Description
5892760 Metabolism
5892799 Metabolism of lipids and lipoproteins
5893777 Sphingolipid de novo biosynthesis
5893778 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR000648 Oxysterol-binding protein
IPR018494 Oxysterol-binding protein, conserved site
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
oxysterol binding protein
Protein Entry
OSBP1_MOUSE
UniProt ID
Q3B7Z2
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3B7Z2-1; Sequence=Displayed; Name=2; IsoId=Q3B7Z2-2; Sequence=VSP_035281, VSP_035282; Note=No experimental confirmation available.;
Domain The PH domain control cholesterol binding without affecting 25-hydroxycholesterol binding. {ECO:0000250}.
Domain The second coiled-coil domain is required for interaction with the tyrosine phosphatase. {ECO:0000250}.
Function Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25- hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability (By similarity). {ECO:0000250}.
Sequence Caution Sequence=AAI07328.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAI07329.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
Similarity Belongs to the OSBP family. {ECO:0000305}.
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subcellular Location Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=When bound to oxysterols, translocates to the periphery of Golgi membranes. {ECO:0000250}.
Subunit Homodimer or homotrimer. Interacts with VAPA (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP006610 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
133504509 RefSeq NP_001028346 805 oxysterol-binding protein 1

Identical Sequences to LMP006610 proteins

Reference Database Accession Length Protein Name
GI:133504509 SwissProt Q3B7Z2.3 805 RecName: Full=Oxysterol-binding protein 1 [Mus musculus]

Related Sequences to LMP006610 proteins

Reference Database Accession Length Protein Name
GI:133504509 GenBank AAA59973.1 807 oxysterol-binding protein [Homo sapiens]
GI:133504509 GenBank AAH11581.1 807 Oxysterol binding protein [Homo sapiens]
GI:133504509 GenBank EAW73849.1 807 oxysterol binding protein [Homo sapiens]
GI:133504509 GenBank AHD74698.1 807 Sequence 14715 from patent US 8586006
GI:133504509 RefSeq XP_006231152.1 805 PREDICTED: oxysterol-binding protein 1 isoform X1 [Rattus norvegicus]
GI:133504509 SwissProt P22059.1 807 RecName: Full=Oxysterol-binding protein 1 [Homo sapiens]