Gene/Proteome Database (LMPD)

LMPD ID
LMP006619
Gene ID
116285
Species
Homo sapiens (Human)
Gene Name
acyl-CoA synthetase medium-chain family member 1
Gene Symbol
ACSM1
Synonyms
BUCS1; MACS1
Alternate Names
acyl-coenzyme A synthetase ACSM1, mitochondrial; Butyrate CoA ligase; butyrate--CoA ligase 1; lipoate-activating enzyme; butyryl Coenzyme A synthetase 1; butyryl-coenzyme A synthetase 1; medium-chain acyl-CoA synthetase; middle-chain acyl-CoA synthetase 1
Chromosome
16
Map Location
16p12.3
EC Number
6.2.1.2

Proteins

acyl-coenzyme A synthetase ACSM1, mitochondrial
Refseq ID NP_443188
Protein GI 115511026
UniProt ID Q08AH1
mRNA ID NM_052956
Length 577
RefSeq Status VALIDATED
MQWLMRFRTLWGIHKSFHNIHPAPSQLRCRSLSEFGAPRWNDYEVPEEFNFASYVLDYWAQKEKEGKRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPRVPEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDALASEVDSIASQCPSLKTKLLVSDHSREGWLDFRSLVKSASPEHTCVKSKTLDPMVIFFTSGTTGFPKMAKHSHGLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVEPWTAGCTVFIHHLPQFDTKVIIQTLLKYPINHFWGVSSIYRMILQQDFTSIRFPALEHCYTGGEVVLPKDQEEWKRRTGLLLYENYGQSETGLICATYWGMKIKPGFMGKATPPYDVQVIDDKGSILPPNTEGNIGIRIKPVRPVSLFMCYEGDPEKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASGYRIGPAEVESALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRKVEFVSELPKTITGKIERKELRKKETGQM
transit_peptide: 1..31 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q08AH1.1) calculated_mol_wt: 3836 peptide sequence: MQWLMRFRTLWGIHKSFHNIHPAPSQLRCRS mat_peptide: 32..577 product: Acyl-coenzyme A synthetase ACSM1, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q08AH1.1) calculated_mol_wt: 61456 peptide sequence: LSEFGAPRWNDYEVPEEFNFASYVLDYWAQKEKEGKRGPNPAFWWVNGQGDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPRVPEWWLVAVGCMRTGIIFIPATILLKAKDILYRLQLSKAKGIVTIDALASEVDSIASQCPSLKTKLLVSDHSREGWLDFRSLVKSASPEHTCVKSKTLDPMVIFFTSGTTGFPKMAKHSHGLALQPSFPGSRKLRSLKTSDVSWCLSDSGWIVATIWTLVEPWTAGCTVFIHHLPQFDTKVIIQTLLKYPINHFWGVSSIYRMILQQDFTSIRFPALEHCYTGGEVVLPKDQEEWKRRTGLLLYENYGQSETGLICATYWGMKIKPGFMGKATPPYDVQVIDDKGSILPPNTEGNIGIRIKPVRPVSLFMCYEGDPEKTAKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASGYRIGPAEVESALVEHPAVAESAVVGSPDPIRGEVVKAFIVLTPQFLSHDKDQLTKELQQHVKSVTAPYKYPRKVEFVSELPKTITGKIERKELRKKETGQM

Gene Information

Entrez Gene ID
116285
Gene Name
acyl-CoA synthetase medium-chain family member 1
Gene Symbol
ACSM1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0072562 IDA:UniProt C blood microparticle
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0005759 IDA:UniProtKB C mitochondrial matrix
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0005525 IEA:UniProtKB-KW F GTP binding
GO:0003996 IDA:UniProtKB F acyl-CoA ligase activity
GO:0047760 IDA:UniProtKB F butyrate-CoA ligase activity
GO:0015645 IEA:Ensembl F fatty acid ligase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0018874 NAS:UniProtKB P benzoate metabolic process
GO:0019605 NAS:UniProtKB P butyrate metabolic process
GO:0042632 NAS:BHF-UCL P cholesterol homeostasis
GO:0015980 NAS:UniProtKB P energy derivation by oxidation of organic compounds
GO:0006633 IEA:Ensembl P fatty acid biosynthetic process
GO:0019395 NAS:UniProtKB P fatty acid oxidation
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006805 TAS:Reactome P xenobiotic metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa01100 Metabolic pathways

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6000 gamma-linolenate biosynthesis II (animals)

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_6933 Conjugation of benzoate with glycine
REACT_6800 Conjugation of phenylacetate with glutamine

Domain Information

InterPro Annotations

Accession Description
IPR025110 AMP-binding enzyme C-terminal domain
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
acyl-CoA synthetase medium-chain family member 1
Protein Entry
ACSM1_HUMAN
UniProt ID
Q08AH1
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q08AH1-1; Sequence=Displayed; Name=2; IsoId=Q08AH1-2; Sequence=VSP_028391;
Catalytic Activity ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.
Catalytic Activity GTP + lipoate = diphosphate + lipoyl-GMP.
Cofactor Name=Mg(2+); Xref=ChEBI
Function Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro). Functions as GTP-dependent lipoate- activating enzyme that generates the substrate for lipoyltransferase (By similarity).
Similarity Belongs to the ATP-dependent AMP-binding enzyme family.
Subcellular Location Mitochondrion matrix .
Subunit Monomer.

Identical and Related Proteins

Unique RefSeq proteins for LMP006619 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
115511026 RefSeq NP_443188 577 acyl-coenzyme A synthetase ACSM1, mitochondrial

Identical Sequences to LMP006619 proteins

Reference Database Accession Length Protein Name
GI:115511026 GenBank AAI25179.1 577 Acyl-CoA synthetase medium-chain family member 1 [Homo sapiens]
GI:115511026 GenBank EAW66826.1 577 acyl-CoA synthetase medium-chain family member 1, isoform CRA_a [Homo sapiens]
GI:115511026 GenBank AIC57579.1 577 ACSM1, partial [synthetic construct]
GI:115511026 RefSeq XP_005255141.1 577 PREDICTED: acyl-coenzyme A synthetase ACSM1, mitochondrial isoform X1 [Homo sapiens]
GI:115511026 SwissProt Q08AH1.1 577 RecName: Full=Acyl-coenzyme A synthetase ACSM1, mitochondrial; AltName: Full=Acyl-CoA synthetase medium-chain family member 1; AltName: Full=Butyrate--CoA ligase 1; AltName: Full=Butyryl-coenzyme A synthetase 1; AltName: Full=Lipoate-activating enzyme; AltName: Full=Middle-chain acyl-CoA synthetase 1; Flags: Precursor [Homo sapiens]

Related Sequences to LMP006619 proteins

Reference Database Accession Length Protein Name
GI:115511026 DBBJ BAB64535.1 577 medium-chain acyl-CoA synthetase [Homo sapiens]
GI:115511026 DBBJ BAB68363.1 577 middle-chain acyl-CoA synthetase1 [Homo sapiens]
GI:115511026 DBBJ BAG36941.1 577 unnamed protein product [Homo sapiens]
GI:115511026 GenBank AHD76082.1 577 Sequence 19355 from patent US 8586006
GI:115511026 RefSeq XP_002826227.1 577 PREDICTED: acyl-coenzyme A synthetase ACSM1, mitochondrial [Pongo abelii]
GI:115511026 RefSeq XP_009248803.1 577 PREDICTED: acyl-coenzyme A synthetase ACSM1, mitochondrial [Pongo abelii]