Gene/Proteome Database (LMPD)
LMPD ID
LMP006621
Gene ID
Species
Homo sapiens (Human)
Gene Name
inositol monophosphatase domain containing 1
Gene Symbol
Synonyms
GPAPP; IMP 3; IMP-3; IMPA3
Alternate Names
inositol monophosphatase 3; IMPase 3; golgi-resident PAP phosphatase; myo-inositol monophosphatase A3; inositol-1(or 4)-monophosphatase 3; inositol monophosphatase domain-containing protein 1; Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase
Chromosome
8
Map Location
8q12.1
EC Number
3.1.3.25
Summary
This gene encodes a member of the inositol monophosphatase family. The encoded protein is localized to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP). Mutations in this gene are a cause of GRAPP type chondrodysplasia with joint dislocations, and a pseudogene of this gene is located on the long arm of chromosome 1. [provided by RefSeq, Dec 2011]
Orthologs
Proteins
| inositol monophosphatase 3 | |
|---|---|
| Refseq ID | NP_060283 |
| Protein GI | 157388900 |
| UniProt ID | Q9NX62 |
| mRNA ID | NM_017813 |
| Length | 359 |
| RefSeq Status | REVIEWED |
| MAPMGIRLSPLGVAVFCLLGLGVLYHLYSGFLAGRFSLFGLGGEPGGGAAGPAAAADGGTVDLREMLAVSVLAAVRGGDEVRRVRESNVLHEKSKGKTREGAEDKMTSGDVLSNRKMFYLLKTAFPSVQINTEEHVDAADQEVILWDHKIPEDILKEVTTPKEVPAESVTVWIDPLDATQEYTEDLRKYVTTMVCVAVNGKPMLGVIHKPFSEYTAWAMVDGGSNVKARSSYNEKTPRIVVSRSHSGMVKQVALQTFGNQTTIIPAGGAGYKVLALLDVPDKSQEKADLYIHVTYIKKWDICAGNAILKALGGHMTTLSGEEISYTGSDGIEGGLLASIRMNHQALVRKLPDLEKTGHK | |
Gene Information
Entrez Gene ID
Gene Name
inositol monophosphatase domain containing 1
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005794 | IDA:MGI | C | Golgi apparatus |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0016020 | IDA:UniProtKB | C | membrane |
| GO:0008441 | IEA:UniProtKB-EC | F | 3'(2'),5'-bisphosphate nucleotidase activity |
| GO:0008254 | IEA:Ensembl | F | 3'-nucleotidase activity |
| GO:0008934 | IEA:UniProtKB-EC | F | inositol monophosphate 1-phosphatase activity |
| GO:0052832 | IEA:UniProtKB-EC | F | inositol monophosphate 3-phosphatase activity |
| GO:0052833 | IEA:UniProtKB-EC | F | inositol monophosphate 4-phosphatase activity |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0002063 | IEA:Ensembl | P | chondrocyte development |
| GO:0030204 | IEA:Ensembl | P | chondroitin sulfate metabolic process |
| GO:0042733 | IEA:Ensembl | P | embryonic digit morphogenesis |
| GO:0001958 | IEA:Ensembl | P | endochondral ossification |
| GO:0006021 | IEA:UniProtKB-UniPathway | P | inositol biosynthetic process |
| GO:0046854 | IEA:InterPro | P | phosphatidylinositol phosphorylation |
| GO:0009791 | IEA:Ensembl | P | post-embryonic development |
KEGG Pathway Links
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-6363 | D-myo-inositol (1,4,5)-trisphosphate degradation |
Domain Information
UniProt Annotations
Entry Information
Gene Name
inositol monophosphatase domain containing 1
Protein Entry
IMPA3_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Adenosine 3',5'-bisphosphate + H(2)O = adenosine 5'-phosphate + phosphate. |
| Catalytic Activity | Myo-inositol phosphate + H(2)O = myo-inositol + phosphate. |
| Cofactor | Name=Mg(2+); Xref=ChEBI |
| Disease | Chondrodysplasia with joint dislocations, GPAPP type (CDP-GPAPP) [MIM |
| Enzyme Regulation | Strongly inhibited by lithium. |
| Function | May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. |
| Pathway | Polyol metabolism; myo-inositol biosynthesis; myo- inositol from D-glucose 6-phosphate: step 2/2. |
| Ptm | Contains N-linked glycan resistant to endoglycosydase H. |
| Similarity | Belongs to the inositol monophosphatase family. |
| Subcellular Location | Golgi apparatus, trans-Golgi network membrane ; Single-pass type II membrane protein . |
Identical and Related Proteins
Unique RefSeq proteins for LMP006621 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 157388900 | RefSeq | NP_060283 | 359 | inositol monophosphatase 3 |
Identical Sequences to LMP006621 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:157388900 | GenBank | JAA05966.1 | 359 | inositol monophosphatase domain containing 1 [Pan troglodytes] |
| GI:157388900 | GenBank | JAA05967.1 | 359 | inositol monophosphatase domain containing 1 [Pan troglodytes] |
| GI:157388900 | GenBank | JAA20573.1 | 359 | inositol monophosphatase domain containing 1 [Pan troglodytes] |
| GI:157388900 | GenBank | JAA20574.1 | 359 | inositol monophosphatase domain containing 1 [Pan troglodytes] |
| GI:157388900 | GenBank | JAA44137.1 | 359 | inositol monophosphatase domain containing 1 [Pan troglodytes] |
| GI:157388900 | GenBank | AIC51674.1 | 359 | IMPAD1, partial [synthetic construct] |
Related Sequences to LMP006621 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:157388900 | GenBank | JAA32608.1 | 416 | inositol monophosphatase domain containing 1 [Pan troglodytes] |
| GI:157388900 | GenBank | JAA32609.1 | 416 | inositol monophosphatase domain containing 1 [Pan troglodytes] |
| GI:157388900 | GenBank | JAA32610.1 | 416 | inositol monophosphatase domain containing 1 [Pan troglodytes] |
| GI:157388900 | RefSeq | XP_002819151.1 | 359 | PREDICTED: inositol monophosphatase 3 [Pongo abelii] |
| GI:157388900 | RefSeq | XP_003256050.1 | 359 | PREDICTED: uncharacterized protein LOC100602566 [Nomascus leucogenys] |
| GI:157388900 | RefSeq | XP_004047099.1 | 359 | PREDICTED: inositol monophosphatase 3 [Gorilla gorilla gorilla] |