LIPID MAPS

Gene/Proteome Database (LMPD)

LMPD ID

LMP006627

Gene ID

79993

Species

Homo sapiens (Human)

Gene Name

ELOVL fatty acid elongase 7

Gene Symbol

ELOVL7

Synonyms

Chromosome

Map Location

5q12.1

EC Number

2.3.1.199

Proteins

elongation of very long chain fatty acids protein 7 isoform 1
Refseq ID	NP_079206
Protein GI	157388947
UniProt ID	A1L3X0
mRNA ID	NM_024930
Length	281
RefSeq Status	VALIDATED
MAFSDLTSRTVHLYDNWIKDADPRVEDWLLMSSPLPQTILLGFYVYFVTSLGPKLMENRKPFELKKAMITYNFFIVLFSVYMCYEFVMSGWGIGYSFRCDIVDYSRSPTALRMARTCWLYYFSKFIELLDTIFFVLRKKNSQVTFLHVFHHTIMPWTWWFGVKFAAGGLGTFHALLNTAVHVVMYSYYGLSALGPAYQKYLWWKKYLTSLQLVQFVIVAIHISQFFFMEDCKYQFPVFACIIMSYSFMFLLLFLHFWYRAYTKGQRLPKTVKNGTCKNKDN

elongation of very long chain fatty acids protein 7 isoform 1
Refseq ID	NP_001098028
Protein GI	157388949
UniProt ID	A1L3X0
mRNA ID	NM_001104558
Length	281
RefSeq Status	VALIDATED
Protein sequence is identical to GI:157388947 (mRNA isoform)

elongation of very long chain fatty acids protein 7 isoform 2
Refseq ID	NP_001284546
Protein GI	662236790
UniProt ID	D6RHD0
mRNA ID	NM_001297617
Length	268
RefSeq Status	VALIDATED
MEKPINILYPRVEDWLLMSSPLPQTILLGFYVYFVTSLGPKLMENRKPFELKKAMITYNFFIVLFSVYMCYEFVMSGWGIGYSFRCDIVDYSRSPTALRMARTCWLYYFSKFIELLDTIFFVLRKKNSQVTFLHVFHHTIMPWTWWFGVKFAAGGLGTFHALLNTAVHVVMYSYYGLSALGPAYQKYLWWKKYLTSLQLVQFVIVAIHISQFFFMEDCKYQFPVFACIIMSYSFMFLLLFLHFWYRAYTKGQRLPKTVKNGTCKNKDN

elongation of very long chain fatty acids protein 7 isoform 3
Refseq ID	NP_001284547
Protein GI	662236790
UniProt ID	A1L3X0
mRNA ID	NM_001297618
Length	268
RefSeq Status	VALIDATED
MEKPINILYPRVEDWLLMSSPLPQTILLGFYVYFVTSLGPKLMENRKPFELKKAMITYNFFIVLFSVYMCYEFVMSGWGIGYSFRCDIVDYSRSPTALRMARTCWLYYFSKFIELLDTIFFVLRKKNSQVTFLHVFHHTIMPWTWWFGVKFAAGGLGTFHALLNTAVHVVMYSYYGLSALGPAYQKYLWWKKYLTSLQLVQFVIVAIHISQFFFMEDCKYQFPVFACIIMSYSFMFLLLFLHFWYRAYTKGQRLPKTVKNGTCKNKDN

Gene Information

Entrez Gene ID

79993

Gene Name

ELOVL fatty acid elongase 7

Gene Symbol

ELOVL7

Species

Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005783	IDA:UniProtKB	C	endoplasmic reticulum
GO:0005789	TAS:Reactome	C	endoplasmic reticulum membrane
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0016740	IEA:UniProtKB-KW	F	transferase activity
GO:0044255	TAS:Reactome	P	cellular lipid metabolic process
GO:0034626	IDA:UniProtKB	P	fatty acid elongation, polyunsaturated fatty acid
GO:0019367	IDA:UniProtKB	P	fatty acid elongation, saturated fatty acid
GO:0035338	TAS:Reactome	P	long-chain fatty-acyl-CoA biosynthetic process
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0019432	TAS:Reactome	P	triglyceride biosynthetic process
GO:0042761	IDA:UniProtKB	P	very long-chain fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID	Description
hsa00062	Fatty acid elongation

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_1319	Fatty Acyl-CoA Biosynthesis
REACT_380	Synthesis of very long-chain fatty acyl-CoAs

Domain Information

InterPro Annotations

Accession	Description
IPR002076	ELO family

UniProt Annotations

Entry Information

Gene Name

ELOVL fatty acid elongase 7

Protein Entry

A1L3X0_HUMAN

UniProt ID

D6RHD0

Species

Human

Comments

Comment Type	Description
Biophysicochemical Properties	Kinetic parameters: KM=2.6 uM for C18:3(n-3)-CoA ; KM=11.7 uM for malonyl-CoA ; Vmax=0.33 pmol/min/ug enzyme toward C18:3(n-3)-CoA ; Vmax=0.31 pmol/min/ug enzyme toward malonyl-CoA ;
Catalytic Activity	A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2).
Domain	The di-lysine motif may confer endoplasmic reticulum localization.
Function	Condensing enzyme that catalyzes the synthesis of saturated and polyunsaturated very long chain fatty acids. Highest activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. {ECO
Sequence Caution	Sequence=BAB15697.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=BAB15697.1; Type=Erroneous termination; Positions=52; Note=Translated as Gly.; Evidence= ; Sequence=BAB15697.1; Type=Frameshift; Positions=138; Evidence= ;
Similarity	Belongs to the ELO family.
Subcellular Location	Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue Specificity	Expressed in most tissues except heart and skeletal muscle.

Identical and Related Proteins

Unique RefSeq proteins for LMP006627 (as displayed in Record Overview)

Protein GI	Database	Accession	Length	Protein Name
157388947	RefSeq	NP_079206	281	elongation of very long chain fatty acids protein 7 isoform 1
662236790	RefSeq	NP_001284546	268	elongation of very long chain fatty acids protein 7 isoform 2
662236790	RefSeq	NP_001284547	268	elongation of very long chain fatty acids protein 7 isoform 3

Identical Sequences to LMP006627 proteins

Reference	Database	Accession	Length	Protein Name
GI:157388947	GenBank	ABY03471.1	281	Sequence 5 from patent US 7297523
GI:157388947	GenBank	ADR83129.1	281	ELOVL family member 7, elongation of long chain fatty acids (yeast) (ELOVL7), transcript variant 2, partial [synthetic construct]
GI:157388947	GenBank	AIC52347.1	281	ELOVL7, partial [synthetic construct]
GI:157388947	GenBank	AIC52348.1	281	ELOVL7, partial [synthetic construct]
GI:157388947	RefSeq	XP_005248663.1	281	PREDICTED: elongation of very long chain fatty acids protein 7 isoform X2 [Homo sapiens]
GI:662236790	RefSeq	XP_005248664.1	268	PREDICTED: elongation of very long chain fatty acids protein 7 isoform X3 [Homo sapiens]
GI:662236790	RefSeq	XP_005248664.1	268	PREDICTED: elongation of very long chain fatty acids protein 7 isoform X3 [Homo sapiens]
GI:157388947	RefSeq	XP_006714758.1	281	PREDICTED: elongation of very long chain fatty acids protein 7 isoform X4 [Homo sapiens]

Related Sequences to LMP006627 proteins

Reference	Database	Accession	Length	Protein Name
GI:157388947	DBBJ	BAD93238.1	281	ELOVL7 [Homo sapiens]
GI:157388947	EMBL	CAM83959.1	281	unnamed protein product [Homo sapiens]
GI:157388947	EMBL	CCD32701.1	281	unnamed protein product [Homo sapiens]
GI:662236790	GenBank	ADR83129.1	281	ELOVL family member 7, elongation of long chain fatty acids (yeast) (ELOVL7), transcript variant 2, partial [synthetic construct]
GI:662236790	GenBank	ADR83129.1	281	ELOVL family member 7, elongation of long chain fatty acids (yeast) (ELOVL7), transcript variant 2, partial [synthetic construct]
GI:157388947	GenBank	AEU56336.1	281	Sequence 15 from patent US 8067153
GI:157388947	GenBank	AHD70390.1	281	Sequence 3065 from patent US 8586006
GI:662236790	GenBank	AIC52347.1	281	ELOVL7, partial [synthetic construct]
GI:662236790	GenBank	AIC52347.1	281	ELOVL7, partial [synthetic construct]
GI:662236790	GenBank	AIC52348.1	281	ELOVL7, partial [synthetic construct]
GI:662236790	GenBank	AIC52348.1	281	ELOVL7, partial [synthetic construct]
GI:157388947	RefSeq	XP_003266018.1	281	PREDICTED: elongation of very long chain fatty acids protein 7 [Nomascus leucogenys]
GI:662236790	RefSeq	XP_005248663.1	281	PREDICTED: elongation of very long chain fatty acids protein 7 isoform X2 [Homo sapiens]
GI:662236790	RefSeq	XP_005248663.1	281	PREDICTED: elongation of very long chain fatty acids protein 7 isoform X2 [Homo sapiens]
GI:662236790	RefSeq	XP_006714758.1	281	PREDICTED: elongation of very long chain fatty acids protein 7 isoform X4 [Homo sapiens]
GI:662236790	RefSeq	XP_006714758.1	281	PREDICTED: elongation of very long chain fatty acids protein 7 isoform X4 [Homo sapiens]
GI:662236790	SwissProt	A1L3X0.1	281	RecName: Full=Elongation of very long chain fatty acids protein 7; AltName: Full=3-keto acyl-CoA synthase ELOVL7; AltName: Full=ELOVL fatty acid elongase 7; Short=ELOVL FA elongase 7; AltName: Full=Very-long-chain 3-oxoacyl-CoA synthase 7 [Homo sapiens]
GI:662236790	SwissProt	A1L3X0.1	281	RecName: Full=Elongation of very long chain fatty acids protein 7; AltName: Full=3-keto acyl-CoA synthase ELOVL7; AltName: Full=ELOVL fatty acid elongase 7; Short=ELOVL FA elongase 7; AltName: Full=Very-long-chain 3-oxoacyl-CoA synthase 7 [Homo sapiens]