Gene/Proteome Database (LMPD)

LMPD ID
LMP006631
Gene ID
51365
Species
Homo sapiens (Human)
Gene Name
phospholipase A1 member A
Gene Symbol
PLA1A
Synonyms
PS-PLA1; PSPLA1
Chromosome
3
Map Location
3q13.13-q13.2
EC Number
3.1.1.-
Summary
The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Orthologs
View orthologs and multiple alignments for PLA1A

Proteins

phospholipase A1 member A isoform 1 precursor
Refseq ID NP_056984
Protein GI 7706661
UniProt ID Q53H76
mRNA ID NM_015900
Length 456
RefSeq Status REVIEWED
MPPGPWESCFWVGGLILWLSVGSSGDAPPTPQPKCADFQSANLFEGTDLKVQFLLFVPSNPSCGQLVEGSSDLQNSGFNATLGTKLIIHGFRVLGTKPSWIDTFIRTLLRATNANVIAVDWIYGSTGVYFSAVKNVIKLSLEISLFLNKLLVLGVSESSIHIIGVSLGAHVGGMVGQLFGGQLGQITGLDPAGPEYTRASVEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPTFFYAGYSYLICDHMRAVHLYISALENSCPLMAFPCASYKAFLAGRCLDCFNPFLLSCPRIGLVEQGGVKIEPLPKEVKVYLLTTSSAPYCMHHSLVEFHLKELRNKDTNIEVTFLSSNITSSSKITIPKQQRYGKGIIAHATPQCQINQVKFKFQSSNRVWKKDRTTIIGKFCTALLPVNDREKMVCLPEPVNLQASVTVSCDLKIACV
sig_peptide: 1..25 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2663 peptide sequence: MPPGPWESCFWVGGLILWLSVGSSG sig_peptide: 1..25 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2663 peptide sequence: MPPGPWESCFWVGGLILWLSVGSSG
phospholipase A1 member A isoform 2 precursor
Refseq ID NP_001193889
Protein GI 332688256
UniProt ID Q53H76
mRNA ID NM_001206960
Length 440
RefSeq Status REVIEWED
MPPGPWESCFWVGGLILWLSVGSSGDAPPTPQPKCADFQSANLFEGTDLKVQFLLFVPSNPSCGQLVEGSSDLQNSGFNATLGTKLIIHGFRVLGTKPSWIDTFIRTLLRATNANVIAVDWIYGSTGVYFSAVKNVLGVSESSIHIIGVSLGAHVGGMVGQLFGGQLGQITGLDPAGPEYTRASVEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPTFFYAGYSYLICDHMRAVHLYISALENSCPLMAFPCASYKAFLAGRCLDCFNPFLLSCPRIGLVEQGGVKIEPLPKEVKVYLLTTSSAPYCMHHSLVEFHLKELRNKDTNIEVTFLSSNITSSSKITIPKQQRYGKGIIAHATPQCQINQVKFKFQSSNRVWKKDRTTIIGKFCTALLPVNDREKMVCLPEPVNLQASVTVSCDLKIACV
phospholipase A1 member A isoform 3
Refseq ID NP_001193890
Protein GI 332688258
UniProt ID Q53H76
mRNA ID NM_001206961
Length 283
RefSeq Status REVIEWED
MVGQLFGGQLGQITGLDPAGPEYTRASVEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPTFFYAGYSYLICDHMRAVHLYISALENSCPLMAFPCASYKAFLAGRCLDCFNPFLLSCPRIGLVEQGGVKIEPLPKEVKVYLLTTSSAPYCMHHSLVEFHLKELRNKDTNIEVTFLSSNITSSSKITIPKQQRYGKGIIAHATPQCQINQVKFKFQSSNRVWKKDRTTIIGKFCTALLPVNDREKMVCLPEPVNLQASVTVSCDLKIACV
phospholipase A1 member A isoform 4
Refseq ID NP_001280154
Protein GI 646227269
UniProt ID G5E9W0
mRNA ID NM_001293225
Length 440
RefSeq Status REVIEWED
MHKSSSIWGDAPPTPQPKCADFQSANLFEGTDLKVQFLLFVPSNPSCGQLVEGSSDLQNSGFNATLGTKLIIHGFRVLGTKPSWIDTFIRTLLRATNANVIAVDWIYGSTGVYFSAVKNVIKLSLEISLFLNKLLVLGVSESSIHIIGVSLGAHVGGMVGQLFGGQLGQITGLDPAGPEYTRASVEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPTFFYAGYSYLICDHMRAVHLYISALENSCPLMAFPCASYKAFLAGRCLDCFNPFLLSCPRIGLVEQGGVKIEPLPKEVKVYLLTTSSAPYCMHHSLVEFHLKELRNKDTNIEVTFLSSNITSSSKITIPKQQRYGKGIIAHATPQCQINQVKFKFQSSNRVWKKDRTTIIGKFCTALLPVNDREKMVCLPEPVNLQASVTVSCDLKIACV

Gene Information

Entrez Gene ID
51365
Gene Name
phospholipase A1 member A
Gene Symbol
PLA1A
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0008970 TAS:ProtInc F phosphatidylcholine 1-acylhydrolase activity
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0006629 TAS:ProtInc P lipid metabolic process
GO:0006658 TAS:ProtInc P phosphatidylserine metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04014 Ras signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR013818 Lipase, N-terminal
IPR016272 Lipoprotein_lipase_LIPH
IPR000734 Triacylglycerol lipase family

UniProt Annotations

Entry Information

Gene Name
phospholipase A1 member A
Protein Entry
PLA1A_HUMAN
UniProt ID
Q53H76
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q53H76-1; Sequence=Displayed; Name=2; Synonyms=DeltaC; IsoId=Q53H76-2; Sequence=VSP_022508, VSP_022509; Name=3; IsoId=Q53H76-3; Sequence=VSP_022507; Note=No experimental confirmation available.; Name=4; IsoId=Q53H76-4; Sequence=VSP_044944; Note=No experimental confirmation available.;
Function Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1- acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production.
Similarity Belongs to the AB hydrolase superfamily. Lipase family.
Subcellular Location Secreted .
Tissue Specificity Widely expressed. Expressed in placenta, prostate and liver. Weakly or not expressed in skin, leukocytes, platelets, colon, spleen, lung, muscle and kidney.

Identical and Related Proteins

Unique RefSeq proteins for LMP006631 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
7706661 RefSeq NP_056984 456 phospholipase A1 member A isoform 1 precursor
332688256 RefSeq NP_001193889 440 phospholipase A1 member A isoform 2 precursor
332688258 RefSeq NP_001193890 283 phospholipase A1 member A isoform 3
646227269 RefSeq NP_001280154 440 phospholipase A1 member A isoform 4

Identical Sequences to LMP006631 proteins

Reference Database Accession Length Protein Name
GI:7706661 DBBJ BAG36299.1 456 unnamed protein product [Homo sapiens]
GI:332688258 DBBJ BAG63314.1 283 unnamed protein product [Homo sapiens]
GI:7706661 DBBJ BAI45768.1 456 phospholipase A1 member A, partial [synthetic construct]
GI:7706661 GenBank AAC98921.1 456 phosphatidylserine-specific phospholipase A1 [Homo sapiens]
GI:7706661 GenBank AAC99994.1 456 similar to the following EST sequences: GenBank Accession Numbers T96213 and T96131; 3'UTR nmd sequence found in U30998 [Homo sapiens]
GI:332688256 GenBank AAH47703.1 440 PLA1A protein [Homo sapiens]
GI:7706661 GenBank EAW79557.1 456 phospholipase A1 member A, isoform CRA_a [Homo sapiens]
GI:646227269 GenBank EAW79558.1 440 phospholipase A1 member A, isoform CRA_b [Homo sapiens]
GI:332688256 GenBank EAW79559.1 440 phospholipase A1 member A, isoform CRA_c [Homo sapiens]
GI:332688256 GenBank ADQ33095.1 440 phospholipase A1 member A, partial [synthetic construct]
GI:332688256 GenBank AIC60110.1 440 PLA1A, partial [synthetic construct]
GI:7706661 SwissProt Q53H76.2 456 RecName: Full=Phospholipase A1 member A; AltName: Full=Phosphatidylserine-specific phospholipase A1; Short=PS-PLA1; Flags: Precursor [Homo sapiens]

Related Sequences to LMP006631 proteins

Reference Database Accession Length Protein Name
GI:7706661 DBBJ BAD96425.1 456 phospholipase A1 member A variant, partial [Homo sapiens]
GI:332688256 DBBJ BAI45768.1 456 phospholipase A1 member A, partial [synthetic construct]
GI:646227269 DBBJ BAI45768.1 456 phospholipase A1 member A, partial [synthetic construct]
GI:332688258 DBBJ BAI45768.1 456 phospholipase A1 member A, partial [synthetic construct]
GI:7706661 EMBL CAH89857.1 456 hypothetical protein [Pongo abelii]
GI:646227269 GenBank AAC98921.1 456 phosphatidylserine-specific phospholipase A1 [Homo sapiens]
GI:332688256 GenBank AAC98921.1 456 phosphatidylserine-specific phospholipase A1 [Homo sapiens]
GI:332688258 GenBank AAC98921.1 456 phosphatidylserine-specific phospholipase A1 [Homo sapiens]
GI:332688256 GenBank AAC99994.1 456 similar to the following EST sequences: GenBank Accession Numbers T96213 and T96131; 3'UTR nmd sequence found in U30998 [Homo sapiens]
GI:646227269 GenBank AAC99994.1 456 similar to the following EST sequences: GenBank Accession Numbers T96213 and T96131; 3'UTR nmd sequence found in U30998 [Homo sapiens]
GI:332688258 GenBank AAC99994.1 456 similar to the following EST sequences: GenBank Accession Numbers T96213 and T96131; 3'UTR nmd sequence found in U30998 [Homo sapiens]
GI:332688256 GenBank EAW79557.1 456 phospholipase A1 member A, isoform CRA_a [Homo sapiens]
GI:332688258 GenBank EAW79557.1 456 phospholipase A1 member A, isoform CRA_a [Homo sapiens]
GI:332688256 RefSeq NP_056984.1 456 phospholipase A1 member A isoform 1 precursor [Homo sapiens]
GI:332688258 RefSeq NP_056984.1 456 phospholipase A1 member A isoform 1 precursor [Homo sapiens]
GI:646227269 RefSeq NP_056984.1 456 phospholipase A1 member A isoform 1 precursor [Homo sapiens]
GI:7706661 RefSeq XP_526277.2 456 PREDICTED: phospholipase A1 member A isoform X1 [Pan troglodytes]
GI:7706661 RefSeq XP_003825197.1 456 PREDICTED: phospholipase A1 member A isoform X1 [Pan paniscus]
GI:7706661 RefSeq XP_004036165.1 456 PREDICTED: phospholipase A1 member A isoform 1 [Gorilla gorilla gorilla]
GI:646227269 RefSeq XP_004036168.1 440 PREDICTED: phospholipase A1 member A isoform 4 [Gorilla gorilla gorilla]
GI:646227269 SwissProt Q53H76.2 456 RecName: Full=Phospholipase A1 member A; AltName: Full=Phosphatidylserine-specific phospholipase A1; Short=PS-PLA1; Flags: Precursor [Homo sapiens]
GI:332688258 SwissProt Q53H76.2 456 RecName: Full=Phospholipase A1 member A; AltName: Full=Phosphatidylserine-specific phospholipase A1; Short=PS-PLA1; Flags: Precursor [Homo sapiens]
GI:332688256 SwissProt Q53H76.2 456 RecName: Full=Phospholipase A1 member A; AltName: Full=Phosphatidylserine-specific phospholipase A1; Short=PS-PLA1; Flags: Precursor [Homo sapiens]
GI:7706661 SwissProt Q5RBQ5.2 456 RecName: Full=Phospholipase A1 member A; Flags: Precursor [Pongo abelii]