Gene/Proteome Database (LMPD)

LMPD ID
LMP006632
Gene ID
23228
Species
Homo sapiens (Human)
Gene Name
phospholipase C-like 2
Gene Symbol
PLCL2
Synonyms
PLCE2
Alternate Names
inactive phospholipase C-like protein 2; PLC-L2; PLC-L(2); PLC-epsilon-2; phospholipase C-L2; phospholipase C-epsilon-2; phospholipase C, epsilon 2
Chromosome
3
Map Location
3p24.3

Proteins

inactive phospholipase C-like protein 2 isoform 1
Refseq ID NP_001137854
Protein GI 221219000
UniProt ID Q9UPR0
mRNA ID NM_001144382
Length 1127
RefSeq Status VALIDATED
MAECGRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCSLGVSGDEARASPTRGPRGVALAPTPSAVVCTLPRESKPGGLPRRSSIIKDGTKQKRERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE
inactive phospholipase C-like protein 2 isoform 2
Refseq ID NP_055999
Protein GI 163644311
UniProt ID Q9UPR0
mRNA ID NM_015184
Length 1001
RefSeq Status VALIDATED
MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE

Gene Information

Entrez Gene ID
23228
Gene Name
phospholipase C-like 2
Gene Symbol
PLCL2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0050811 IDA:MGI F GABA receptor binding
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004435 IEA:InterPro F phosphatidylinositol phospholipase C activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0002322 IEA:Ensembl P B cell proliferation involved in immune response
GO:0002337 IEA:Ensembl P B-1a B cell differentiation
GO:0007214 IEA:Ensembl P gamma-aminobutyric acid signaling pathway
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0006629 IEA:InterPro P lipid metabolic process
GO:0050859 IEA:Ensembl P negative regulation of B cell receptor signaling pathway
GO:1900122 IEA:Ensembl P positive regulation of receptor binding
GO:0033135 IEA:Ensembl P regulation of peptidyl-serine phosphorylation
GO:0032228 IEA:Ensembl P regulation of synaptic transmission, GABAergic

Domain Information

InterPro Annotations

Accession Description
IPR000008 C2 domain
IPR011992 EF-hand domain pair
IPR028383 Inactive phospholipase C-like protein 2
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
phospholipase C-like 2
Protein Entry
PLCL2_HUMAN
UniProt ID
Q9UPR0
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9UPR0-1; Sequence=Displayed; Name=2; IsoId=Q9UPR0-2; Sequence=VSP_025790, VSP_025791, VSP_025792; Note=No experimental confirmation available.; Name=3; IsoId=Q9UPR0-3; Sequence=VSP_025790;
Caution In the PI-PLC X-box Thr-486 is present instead of the conserved His which is one of the active site residues. It is therefore expected that this protein lacks catalytic activity.
Function May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.
Sequence Caution Sequence=BAA83044.1; Type=Erroneous initiation; Evidence= ; Sequence=BAB14606.1; Type=Erroneous initiation; Evidence= ;
Similarity Contains 1 C2 domain. {ECO
Similarity Contains 1 PH domain. {ECO
Similarity Contains 1 PI-PLC X-box domain. {ECO
Similarity Contains 1 PI-PLC Y-box domain. {ECO
Subcellular Location Cytoplasm. Note=Predominantly localized to perinuclear areas in both myoblast and myotube C2C12 cells.

Identical and Related Proteins

Unique RefSeq proteins for LMP006632 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
221219000 RefSeq NP_001137854 1127 inactive phospholipase C-like protein 2 isoform 1
163644311 RefSeq NP_055999 1001 inactive phospholipase C-like protein 2 isoform 2

Identical Sequences to LMP006632 proteins

Reference Database Accession Length Protein Name
GI:163644311 DBBJ BAF84108.1 1001 unnamed protein product [Homo sapiens]
GI:221219000 DBBJ BAG09965.1 1127 phospholipase C-like 2, partial [synthetic construct]
GI:221219000 EMBL CAF32891.1 1127 unnamed protein product [Homo sapiens]
GI:221219000 GenBank EAW64282.1 1127 phospholipase C-like 2, isoform CRA_a [Homo sapiens]
GI:221219000 RefSeq XP_526146.3 1127 PREDICTED: inactive phospholipase C-like protein 2 [Pan troglodytes]
GI:163644311 RefSeq XP_003826237.1 1001 PREDICTED: inactive phospholipase C-like protein 2 [Pan paniscus]
GI:163644311 RefSeq XP_008949906.1 1001 PREDICTED: inactive phospholipase C-like protein 2 [Pan paniscus]
GI:221219000 SwissProt Q9UPR0.2 1127 RecName: Full=Inactive phospholipase C-like protein 2; Short=PLC-L(2); Short=PLC-L2; Short=Phospholipase C-L2; AltName: Full=Phospholipase C-epsilon-2; Short=PLC-epsilon-2 [Homo sapiens]

Related Sequences to LMP006632 proteins

Reference Database Accession Length Protein Name
GI:163644311 DBBJ BAA83044.1 1154 KIAA1092 protein, partial [Homo sapiens]
GI:221219000 DBBJ BAA83044.1 1154 KIAA1092 protein, partial [Homo sapiens]
GI:163644311 DBBJ BAG09965.1 1127 phospholipase C-like 2, partial [synthetic construct]
GI:163644311 EMBL CAF32891.1 1127 unnamed protein product [Homo sapiens]
GI:221219000 GenBank AAR81312.1 1154 Sequence 7 from patent US 6660483
GI:163644311 GenBank AAR81312.1 1154 Sequence 7 from patent US 6660483
GI:163644311 GenBank EAW64282.1 1127 phospholipase C-like 2, isoform CRA_a [Homo sapiens]
GI:221219000 GenBank AFJ70932.1 1127 inactive phospholipase C-like protein 2 isoform 1 [Macaca mulatta]
GI:163644311 RefSeq XP_526146.3 1127 PREDICTED: inactive phospholipase C-like protein 2 [Pan troglodytes]
GI:221219000 RefSeq XP_002814070.2 1127 PREDICTED: inactive phospholipase C-like protein 2 [Pongo abelii]
GI:221219000 RefSeq XP_005545744.1 1127 PREDICTED: inactive phospholipase C-like protein 2 isoform X2 [Macaca fascicularis]
GI:221219000 RefSeq XP_008007426.1 1127 PREDICTED: inactive phospholipase C-like protein 2 isoform X1 [Chlorocebus sabaeus]