Gene/Proteome Database (LMPD)
LMPD ID
LMP006632
Gene ID
Species
Homo sapiens (Human)
Gene Name
phospholipase C-like 2
Gene Symbol
Synonyms
PLCE2
Alternate Names
inactive phospholipase C-like protein 2; PLC-L2; PLC-L(2); PLC-epsilon-2; phospholipase C-L2; phospholipase C-epsilon-2; phospholipase C, epsilon 2
Chromosome
3
Map Location
3p24.3
Proteins
| inactive phospholipase C-like protein 2 isoform 1 | |
|---|---|
| Refseq ID | NP_001137854 |
| Protein GI | 221219000 |
| UniProt ID | Q9UPR0 |
| mRNA ID | NM_001144382 |
| Length | 1127 |
| RefSeq Status | VALIDATED |
| MAECGRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCSLGVSGDEARASPTRGPRGVALAPTPSAVVCTLPRESKPGGLPRRSSIIKDGTKQKRERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE | |
| inactive phospholipase C-like protein 2 isoform 2 | |
|---|---|
| Refseq ID | NP_055999 |
| Protein GI | 163644311 |
| UniProt ID | Q9UPR0 |
| mRNA ID | NM_015184 |
| Length | 1001 |
| RefSeq Status | VALIDATED |
| MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IEA:UniProtKB-KW | C | cytoplasm |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0050811 | IDA:MGI | F | GABA receptor binding |
| GO:0004435 | IEA:InterPro | F | phosphatidylinositol phospholipase C activity |
| GO:0004871 | IEA:UniProtKB-KW | F | signal transducer activity |
| GO:0002337 | IEA:Ensembl | P | B-1a B cell differentiation |
| GO:0002322 | IEA:Ensembl | P | B cell proliferation involved in immune response |
| GO:0007214 | IEA:Ensembl | P | gamma-aminobutyric acid signaling pathway |
| GO:0035556 | IEA:InterPro | P | intracellular signal transduction |
| GO:0006629 | IEA:InterPro | P | lipid metabolic process |
| GO:0050859 | IEA:Ensembl | P | negative regulation of B cell receptor signaling pathway |
| GO:1900122 | IEA:Ensembl | P | positive regulation of receptor binding |
| GO:0033135 | IEA:Ensembl | P | regulation of peptidyl-serine phosphorylation |
| GO:0032228 | IEA:Ensembl | P | regulation of synaptic transmission, GABAergic |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR000008 | C2 domain |
| IPR011992 | EF-hand domain pair |
| IPR028383 | Inactive phospholipase C-like protein 2 |
| IPR001192 | Phosphoinositide phospholipase C family |
| IPR000909 | Phospholipase C, phosphatidylinositol-specific , X domain |
| IPR001711 | Phospholipase C, phosphatidylinositol-specific, Y domain |
| IPR015359 | Phospholipase C, phosphoinositol-specific, EF-hand-like |
| IPR017946 | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain |
| IPR001849 | Pleckstrin homology domain |
| IPR011993 | Pleckstrin homology-like domain |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9UPR0-1; Sequence=Displayed; Name=2; IsoId=Q9UPR0-2; Sequence=VSP_025790, VSP_025791, VSP_025792; Note=No experimental confirmation available.; Name=3; IsoId=Q9UPR0-3; Sequence=VSP_025790; |
| Caution | In the PI-PLC X-box Thr-486 is present instead of the conserved His which is one of the active site residues. It is therefore expected that this protein lacks catalytic activity. |
| Function | May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum. |
| Sequence Caution | Sequence=BAA83044.1; Type=Erroneous initiation; Evidence= ; Sequence=BAB14606.1; Type=Erroneous initiation; Evidence= ; |
| Similarity | Contains 1 C2 domain. {ECO |
| Similarity | Contains 1 PH domain. {ECO |
| Similarity | Contains 1 PI-PLC X-box domain. {ECO |
| Similarity | Contains 1 PI-PLC Y-box domain. {ECO |
| Subcellular Location | Cytoplasm. Note=Predominantly localized to perinuclear areas in both myoblast and myotube C2C12 cells. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006632 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 221219000 | RefSeq | NP_001137854 | 1127 | inactive phospholipase C-like protein 2 isoform 1 |
| 163644311 | RefSeq | NP_055999 | 1001 | inactive phospholipase C-like protein 2 isoform 2 |
Identical Sequences to LMP006632 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:163644311 | DBBJ | BAF84108.1 | 1001 | unnamed protein product [Homo sapiens] |
| GI:221219000 | DBBJ | BAG09965.1 | 1127 | phospholipase C-like 2, partial [synthetic construct] |
| GI:221219000 | EMBL | CAF32891.1 | 1127 | unnamed protein product [Homo sapiens] |
| GI:221219000 | GenBank | EAW64282.1 | 1127 | phospholipase C-like 2, isoform CRA_a [Homo sapiens] |
| GI:221219000 | RefSeq | XP_526146.3 | 1127 | PREDICTED: inactive phospholipase C-like protein 2 [Pan troglodytes] |
| GI:163644311 | RefSeq | XP_003826237.1 | 1001 | PREDICTED: inactive phospholipase C-like protein 2 [Pan paniscus] |
| GI:163644311 | RefSeq | XP_008949906.1 | 1001 | PREDICTED: inactive phospholipase C-like protein 2 [Pan paniscus] |
| GI:221219000 | SwissProt | Q9UPR0.2 | 1127 | RecName: Full=Inactive phospholipase C-like protein 2; Short=PLC-L(2); Short=PLC-L2; Short=Phospholipase C-L2; AltName: Full=Phospholipase C-epsilon-2; Short=PLC-epsilon-2 [Homo sapiens] |
Related Sequences to LMP006632 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:163644311 | DBBJ | BAA83044.1 | 1154 | KIAA1092 protein, partial [Homo sapiens] |
| GI:221219000 | DBBJ | BAA83044.1 | 1154 | KIAA1092 protein, partial [Homo sapiens] |
| GI:163644311 | DBBJ | BAG09965.1 | 1127 | phospholipase C-like 2, partial [synthetic construct] |
| GI:163644311 | EMBL | CAF32891.1 | 1127 | unnamed protein product [Homo sapiens] |
| GI:221219000 | GenBank | AAR81312.1 | 1154 | Sequence 7 from patent US 6660483 |
| GI:163644311 | GenBank | AAR81312.1 | 1154 | Sequence 7 from patent US 6660483 |
| GI:163644311 | GenBank | EAW64282.1 | 1127 | phospholipase C-like 2, isoform CRA_a [Homo sapiens] |
| GI:221219000 | GenBank | AFJ70932.1 | 1127 | inactive phospholipase C-like protein 2 isoform 1 [Macaca mulatta] |
| GI:163644311 | RefSeq | XP_526146.3 | 1127 | PREDICTED: inactive phospholipase C-like protein 2 [Pan troglodytes] |
| GI:221219000 | RefSeq | XP_002814070.2 | 1127 | PREDICTED: inactive phospholipase C-like protein 2 [Pongo abelii] |
| GI:221219000 | RefSeq | XP_005545744.1 | 1127 | PREDICTED: inactive phospholipase C-like protein 2 isoform X2 [Macaca fascicularis] |
| GI:221219000 | RefSeq | XP_008007426.1 | 1127 | PREDICTED: inactive phospholipase C-like protein 2 isoform X1 [Chlorocebus sabaeus] |