Gene/Proteome Database (LMPD)
LMPD ID
LMP006636
Gene ID
Species
Homo sapiens (Human)
Gene Name
lipase, endothelial
Gene Symbol
Synonyms
EDL; EL; PRO719
Alternate Names
endothelial lipase; lipoprotein lipase H; endothelial cell-derived lipase
Chromosome
18
Map Location
18q21.1
EC Number
3.1.1.3
Summary
The protein encoded by this gene has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. This protein is designated a member of the TG lipase family by its sequence and characteristic lid region which provides substrate specificity for enzymes of the TG lipase family. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| endothelial lipase precursor | |
|---|---|
| Refseq ID | NP_006024 |
| Protein GI | 5174497 |
| UniProt ID | Q9Y5X9 |
| mRNA ID | NM_006033 |
| Length | 500 |
| RefSeq Status | REVIEWED |
| MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWFRKCRDGWRMKNETSPTVELP | |
| sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2213 peptide sequence: MSNSVPLLCFWSLCYCFAAG mat_peptide: 21..500 product: endothelial lipase calculated_mol_wt: 54600 peptide sequence: SPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWFRKCRDGWRMKNETSPTVELP | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005615 | IDA:BHF-UCL | C | extracellular space |
| GO:0008201 | IEA:UniProtKB-KW | F | heparin binding |
| GO:0004465 | IEA:InterPro | F | lipoprotein lipase activity |
| GO:0008970 | IDA:MGI | F | phosphatidylcholine 1-acylhydrolase activity |
| GO:0004620 | IDA:BHF-UCL | F | phospholipase activity |
| GO:0008283 | IEA:Ensembl | P | cell proliferation |
| GO:0042632 | IMP:BHF-UCL | P | cholesterol homeostasis |
| GO:0034375 | IMP:BHF-UCL | P | high-density lipoprotein particle remodeling |
| GO:0006629 | TAS:ProtInc | P | lipid metabolic process |
| GO:0009395 | NAS:BHF-UCL | P | phospholipid catabolic process |
| GO:0055091 | IMP:BHF-UCL | P | phospholipid homeostasis |
| GO:0032376 | IDA:BHF-UCL | P | positive regulation of cholesterol transport |
| GO:0010983 | IMP:BHF-UCL | P | positive regulation of high-density lipoprotein particle clearance |
| GO:0050746 | IEA:Ensembl | P | regulation of lipoprotein metabolic process |
| GO:0007584 | IEA:Ensembl | P | response to nutrient |
| GO:0043691 | IMP:BHF-UCL | P | reverse cholesterol transport |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y5X9-1; Sequence=Displayed; Name=2; IsoId=Q9Y5X9-2; Sequence=VSP_013302, VSP_013303; Note=No experimental confirmation available.; |
| Catalytic Activity | Triacylglycerol + H(2)O = diacylglycerol + a carboxylate. |
| Enzyme Regulation | Inhibited by serum. |
| Function | Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin. |
| Miscellaneous | It is termed endothelial lipase due to the fact that it is synthesized in endothelial cells, a characteristic that distinguishes it from other members of the family. However, this protein is also expressed in other cell types. |
| Similarity | Belongs to the AB hydrolase superfamily. Lipase family. |
| Similarity | Contains 1 PLAT domain. {ECO |
| Subcellular Location | Secreted. |
| Subunit | Head to tail homodimer. |
| Tissue Specificity | High level of expression in the liver, placenta, lung, thyroid, kidney, testis and in the corpus luteum of the ovary. Expressed also in coronary artery endothelial cells, umbilical vein endothelial cells and in hepatocytes and osteosarcoma cell lines. Not detected in heart, brain and muscle. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006636 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 5174497 | RefSeq | NP_006024 | 500 | endothelial lipase precursor |
Identical Sequences to LMP006636 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:5174497 | GenBank | AFL26278.1 | 500 | Sequence 627 from patent US 8168586 |
| GI:5174497 | GenBank | AGN45439.1 | 500 | Sequence 8 from patent US 8343494 |
| GI:5174497 | GenBank | AGV82303.1 | 500 | Sequence 625 from patent US 8524238 |
| GI:5174497 | GenBank | AGV82304.1 | 500 | Sequence 626 from patent US 8524238 |
| GI:5174497 | GenBank | AGV82305.1 | 500 | Sequence 627 from patent US 8524238 |
| GI:5174497 | GenBank | AHD76749.1 | 500 | Sequence 20969 from patent US 8586006 |
Related Sequences to LMP006636 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:5174497 | DBBJ | BAF84488.1 | 500 | unnamed protein product [Homo sapiens] |
| GI:5174497 | GenBank | AAH60825.1 | 500 | Lipase, endothelial [Homo sapiens] |
| GI:5174497 | GenBank | JAA02858.1 | 500 | lipase, endothelial [Pan troglodytes] |
| GI:5174497 | GenBank | JAA11725.1 | 500 | lipase, endothelial [Pan troglodytes] |
| GI:5174497 | GenBank | AIC55575.1 | 500 | LIPG, partial [synthetic construct] |
| GI:5174497 | RefSeq | XP_003827256.1 | 500 | PREDICTED: endothelial lipase isoform X1 [Pan paniscus] |