Gene/Proteome Database (LMPD)
LMPD ID
LMP006637
Gene ID
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol 4-kinase type 2 beta
Gene Symbol
Synonyms
PI4KIIB; PIK42B
Alternate Names
phosphatidylinositol 4-kinase type 2-beta; PI4KII-BETA; phosphatidylinositol 4-kinase type II-beta; phosphatidylinositol 4-kinase type-II beta
Chromosome
4
Map Location
4p15.2
EC Number
2.7.1.67
Summary
Phosphatidylinositol 4-kinases (PI4Ks) phosphorylate phosphatidylinositol to generate phosphatidylinositol 4-phosphate (PIP), an immediate precursor of several important signaling and scaffolding molecules. PIP itself may also have direct functional and structural roles. PI4K2B is a primarily cytosolic PI4K that is recruited to membranes, where it stimulates phosphatidylinositol 4,5-bisphosphate synthesis (Wei et al., 2002 [PubMed 12324459]).[supplied by OMIM, Jun 2008]
Orthologs
Proteins
| phosphatidylinositol 4-kinase type 2-beta | |
|---|---|
| Refseq ID | NP_060793 |
| Protein GI | 224591401 |
| UniProt ID | Q8TCG2 |
| mRNA ID | NM_018323 |
| Length | 481 |
| RefSeq Status | VALIDATED |
| MEDPSEPDRLASADGGSPEEEEDGEREPLLPRIAWAHPRRGAPGSAVRLLDAAGEEGEAGDEELPLPPGDVGVSRSSSAELDRSRPAVSVTIGTSEMNAFLDDPEFADIMLRAEQAIEVGIFPERISQGSSGSYFVKDPKRKIIGVFKPKSEEPYGQLNPKWTKYVHKVCCPCCFGRGCLIPNQGYLSEAGAYLVDNKLHLSIVPKTKVVWLVSETFNYNAIDRAKSRGKKYALEKVPKVGRKFHRIGLPPKIGSFQLFVEGYKEAEYWLRKFEADPLPENIRKQFQSQFERLVILDYIIRNTDRGNDNWLVRYEKQKCEKEIDHKESKWIDDEEFLIKIAAIDNGLAFPFKHPDEWRAYPFHWAWLPQAKVPFSEEIRNLILPYISDMNFVQDLCEDLYELFKTDKGFDKATFESQMSVMRGQILNLTQALRDGKSPFQLVQIPCVIVERSQGGSQGRIVHLSNSFTQTVNCRKPFFSSW | |
Gene Information
Entrez Gene ID
Gene Name
phosphatidylinositol 4-kinase type 2 beta
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IDA:HPA | C | cytoplasm |
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0016020 | IDA:UniProtKB | C | membrane |
| GO:0004430 | IEA:UniProtKB-EC | F | 1-phosphatidylinositol 4-kinase activity |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0006661 | TAS:Reactome | P | phosphatidylinositol biosynthetic process |
| GO:0006644 | TAS:Reactome | P | phospholipid metabolic process |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_121168 | Synthesis of PIPs at the ER membrane |
| REACT_120836 | Synthesis of PIPs at the Golgi membrane |
| REACT_120756 | Synthesis of PIPs at the early endosome membrane |
| REACT_121025 | Synthesis of PIPs at the plasma membrane |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
UniProt Annotations
Entry Information
Gene Name
phosphatidylinositol 4-kinase type 2 beta
Protein Entry
P4K2B_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate. |
| Enzyme Regulation | Recruited and activated by membrane association. Binding to the microsomal membrane has been shown to enhance its activity. |
| Function | Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. |
| Similarity | Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily. |
| Similarity | Contains 1 PI3K/PI4K domain. |
| Subcellular Location | Cytoplasm. Membrane. Note=Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes where it is recruited by PDGF stimulation by a Rac- GTP-dependent mechanism. |
| Tissue Specificity | Widely expressed. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006637 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 224591401 | RefSeq | NP_060793 | 481 | phosphatidylinositol 4-kinase type 2-beta |
Identical Sequences to LMP006637 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:224591401 | EMBL | CAZ64455.1 | 481 | unnamed protein product [Homo sapiens] |
| GI:224591401 | GenBank | AAM12049.1 | 481 | phosphatidylinositol 4-kinase type-II beta [Homo sapiens] |
| GI:224591401 | SwissProt | Q8TCG2.1 | 481 | RecName: Full=Phosphatidylinositol 4-kinase type 2-beta; AltName: Full=Phosphatidylinositol 4-kinase type II-beta; Short=PI4KII-BETA [Homo sapiens] |
Related Sequences to LMP006637 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:224591401 | DBBJ | BAA92006.1 | 481 | unnamed protein product [Homo sapiens] |
| GI:224591401 | EMBL | CAE89927.1 | 481 | unnamed protein product [Homo sapiens] |
| GI:224591401 | GenBank | AAL04154.1 | 481 | type II phosphatidylinositol 4-kinase beta isoform [Homo sapiens] |
| GI:224591401 | GenBank | AAL47580.1 | 481 | phosphatidylinositol 4-kinase type-II beta [Homo sapiens] |
| GI:224591401 | GenBank | AAH51749.1 | 481 | Phosphatidylinositol 4-kinase type 2 beta [Homo sapiens] |
| GI:224591401 | GenBank | AIC56664.1 | 481 | PI4K2B, partial [synthetic construct] |