Gene/Proteome Database (LMPD)
LMPD ID
LMP006640
Gene ID
Species
Homo sapiens (Human)
Gene Name
phospholipase C, delta 4
Gene Symbol
Synonyms
-
Alternate Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; PLC delta4; phosphoinositide phospholipase C-delta-4; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4
Chromosome
2
Map Location
2q35
EC Number
3.1.4.11
Summary
This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011]
Orthologs
Proteins
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 | |
|---|---|
| Refseq ID | NP_116115 |
| Protein GI | 14249340 |
| UniProt ID | Q9BRC7 |
| mRNA ID | NM_032726 |
| Length | 762 |
| RefSeq Status | REVIEWED |
| MASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSELLRSLAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVATVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEELRRKILVKGKKLTLEEDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQNKDKKKKSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHPEKPISPFKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYWGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKDGISLRPASIFVYICIQEGLEGDES | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0016020 | IEA:UniProtKB-KW | C | membrane |
| GO:0005634 | IEA:UniProtKB-KW | C | nucleus |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0004435 | IEA:UniProtKB-EC | F | phosphatidylinositol phospholipase C activity |
| GO:0004871 | IEA:UniProtKB-KW | F | signal transducer activity |
| GO:0007340 | IEA:Ensembl | P | acrosome reaction |
| GO:0035556 | IEA:InterPro | P | intracellular signal transduction |
| GO:0016042 | IEA:UniProtKB-KW | P | lipid catabolic process |
| GO:0046488 | IEA:InterPro | P | phosphatidylinositol metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa04020 | Calcium signaling pathway |
| hsa04919 | Thyroid hormone signaling pathway |
BIOCYC Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR028387 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 |
| IPR000008 | C2 domain |
| IPR018247 | EF-Hand 1, calcium-binding site |
| IPR002048 | EF-hand domain |
| IPR011992 | EF-hand domain pair |
| IPR017946 | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain |
| IPR001192 | Phosphoinositide phospholipase C family |
| IPR000909 | Phospholipase C, phosphatidylinositol-specific , X domain |
| IPR001711 | Phospholipase C, phosphatidylinositol-specific, Y domain |
| IPR015359 | Phospholipase C, phosphoinositol-specific, EF-hand-like |
| IPR001849 | Pleckstrin homology domain |
| IPR011993 | Pleckstrin homology-like domain |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BRC7-1; Sequence=Displayed; Note=Acceptor splice site between exons 4 and 5 is non-canonical but conserved through species for that particular gene.; Name=2; Synonyms=PLCD4b; IsoId=Q9BRC7-2; Sequence=VSP_028501, VSP_028502; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; |
| Catalytic Activity | 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. |
| Cofactor | Name=Ca(2+); Xref=ChEBI |
| Domain | The C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective Ca(2+)-mediated targeting to various cellular membranes. |
| Domain | The PDZ-binding motif mediates the interaction with GRIP1. |
| Domain | The PH domain is not a critical determinant of the membrane localization. |
| Function | Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. |
| Similarity | Contains 1 C2 domain. {ECO |
| Similarity | Contains 1 PH domain. {ECO |
| Similarity | Contains 1 PI-PLC X-box domain. {ECO |
| Similarity | Contains 1 PI-PLC Y-box domain. {ECO |
| Similarity | Contains 3 EF-hand domains. {ECO |
| Subcellular Location | Membrane ; Peripheral membrane protein {ECO |
| Subunit | Interacts with GRIP1. |
| Tissue Specificity | Highly expressed in skeletal muscle and kidney tissues, and at moderate level in intestinal tissue. Expressed in corneal epithelial cells. {ECO |
Identical and Related Proteins
Unique RefSeq proteins for LMP006640 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 14249340 | RefSeq | NP_116115 | 762 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 |
Identical Sequences to LMP006640 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:14249340 | EMBL | CBU96775.1 | 762 | unnamed protein product [Homo sapiens] |
| GI:14249340 | GenBank | ADM05351.1 | 762 | Sequence 40 from patent US 7732182 |
| GI:14249340 | GenBank | AED62133.1 | 762 | Sequence 15 from patent US 7902154 |
| GI:14249340 | GenBank | AGX54763.1 | 762 | Sequence 9882 from patent US 8541208 |
| GI:14249340 | GenBank | AGX64203.1 | 762 | Sequence 28516 from patent US 8541208 |
| GI:14249340 | GenBank | AIC52613.1 | 762 | PLCD4, partial [synthetic construct] |
Related Sequences to LMP006640 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:14249340 | DBBJ | BAD96923.1 | 762 | phospholipase C, delta 4 variant, partial [Homo sapiens] |
| GI:14249340 | RefSeq | XP_005246970.1 | 788 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [Homo sapiens] |
| GI:14249340 | RefSeq | XP_006712866.1 | 788 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X5 [Homo sapiens] |
| GI:14249340 | RefSeq | XP_008970209.1 | 762 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X5 [Pan paniscus] |
| GI:14249340 | RefSeq | XP_009442581.1 | 762 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X2 [Pan troglodytes] |
| GI:14249340 | RefSeq | XP_009442582.1 | 762 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X2 [Pan troglodytes] |