Gene/Proteome Database (LMPD)
LMPD ID
LMP006645
Gene ID
Species
Homo sapiens (Human)
Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
Gene Symbol
Synonyms
B3GN-T4; beta3Gn-T4
Alternate Names
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4; BGnT-4; beta-1,3-Gn-T4; beta-1,3-N-acetylglucosaminyltransferase 4; beta-1,3-N-acetylglucosaminyltransferase bGn-T4
Chromosome
12
Map Location
12q24
EC Number
2.4.1.-
Summary
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase protein family. The encoded enzyme is involved in the biosynthesis of poly-N-acetyllactosamine chains and prefers lacto-N-neotetraose as a substrate. It is a type II transmembrane protein. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 | |
|---|---|
| Refseq ID | NP_110392 |
| Protein GI | 13540527 |
| UniProt ID | Q9C0J1 |
| mRNA ID | NM_030765 |
| Length | 378 |
| RefSeq Status | REVIEWED |
| MLPPQPSAAHQGRGGRSGLLPKGPAMLCRLCWLVSYSLAVLLLGCLLFLRKAAKPAGDPTAHQPFWAPPTPRHSRCPPNHTVSSASLSLPSRHRLFLTYRHCRNFSILLEPSGCSKDTFLLLAIKSQPGHVERRAAIRSTWGRVGGWARGRQLKLVFLLGVAGSAPPAQLLAYESREFDDILQWDFTEDFFNLTLKELHLQRWVVAACPQAHFMLKGDDDVFVHVPNVLEFLDGWDPAQDLLVGDVIRQALPNRNTKVKYFIPPSMYRATHYPPYAGGGGYVMSRATVRRLQAIMEDAELFPIDDVFVGMCLRRLGLSPMHHAGFKTFGIRRPLDPLDPCLYRGLLLVHRLSPLEMWTMWALVTDEGLKCAAGPIPQR | |
Gene Information
Entrez Gene ID
Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0000139 | TAS:Reactome | C | Golgi membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0008378 | IEA:InterPro | F | galactosyltransferase activity |
| GO:0005975 | TAS:Reactome | P | carbohydrate metabolic process |
| GO:0044267 | TAS:Reactome | P | cellular protein metabolic process |
| GO:0030203 | TAS:Reactome | P | glycosaminoglycan metabolic process |
| GO:0018146 | TAS:Reactome | P | keratan sulfate biosynthetic process |
| GO:0042339 | TAS:Reactome | P | keratan sulfate metabolic process |
| GO:0016266 | TAS:Reactome | P | O-glycan processing |
| GO:0043687 | TAS:Reactome | P | post-translational protein modification |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_121315 | Glycosaminoglycan metabolism |
| REACT_121120 | Keratan sulfate biosynthesis |
| REACT_121288 | Keratan sulfate/keratin metabolism |
| REACT_200727 | O-linked glycosylation |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR002659 | Glycosyl transferase, family 31 |
UniProt Annotations
Entry Information
Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
Protein Entry
B3GN4_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9C0J1-1; Sequence=Displayed; Name=2; IsoId=Q9C0J1-2; Sequence=VSP_025962; |
| Function | Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides. |
| Pathway | Protein modification; protein glycosylation. |
| Sequence Caution | Sequence=AAL37219.1; Type=Erroneous initiation; Evidence= ; |
| Similarity | Belongs to the glycosyltransferase 31 family. |
| Subcellular Location | Golgi apparatus membrane ; Single-pass type II membrane protein . |
| Tissue Specificity | Mainly expressed in brain tissues such as whole brain, hippocampus, amygdala, cerebellum and caudate nucleus. Also expressed in colon, esophagus and kidney. |
| Web Resource | Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GNT4"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP006645 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 13540527 | RefSeq | NP_110392 | 378 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 |
Identical Sequences to LMP006645 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:13540527 | GenBank | ACP58704.1 | 378 | Sequence 36 from patent US 7491797 |
| GI:13540527 | GenBank | ACP88639.1 | 378 | Sequence 36 from patent US 7504480 |
| GI:13540527 | GenBank | ACW43159.1 | 378 | Sequence 36 from patent US 7582293 |
| GI:13540527 | GenBank | ACW64613.1 | 378 | Sequence 36 from patent US 7589172 |
| GI:13540527 | GenBank | ADS45528.1 | 378 | Sequence 36 from patent US 7795412 |
| GI:13540527 | GenBank | AEK14089.1 | 378 | Sequence 4 from patent US 7972815 |
Related Sequences to LMP006645 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:13540527 | GenBank | AAM17730.1 | 378 | Sequence 2 from patent US 6361985 |
| GI:13540527 | GenBank | AAH31399.1 | 378 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 [Homo sapiens] |
| GI:13540527 | GenBank | ABM82210.1 | 378 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 [synthetic construct] |
| GI:13540527 | GenBank | ABM85395.1 | 378 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4, partial [synthetic construct] |
| GI:13540527 | RefSeq | XP_001166798.1 | 378 | PREDICTED: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 isoform X1 [Pan troglodytes] |
| GI:13540527 | RefSeq | XP_008955984.1 | 378 | PREDICTED: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 [Pan paniscus] |