Gene/Proteome Database (LMPD)

LMPD ID
LMP006645
Gene ID
Species
Homo sapiens (Human)
Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
Gene Symbol
Synonyms
B3GN-T4; beta3Gn-T4
Alternate Names
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4; BGnT-4; beta-1,3-Gn-T4; beta-1,3-N-acetylglucosaminyltransferase 4; beta-1,3-N-acetylglucosaminyltransferase bGn-T4
Chromosome
12
Map Location
12q24
EC Number
2.4.1.-
Summary
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase protein family. The encoded enzyme is involved in the biosynthesis of poly-N-acetyllactosamine chains and prefers lacto-N-neotetraose as a substrate. It is a type II transmembrane protein. [provided by RefSeq, Jul 2008]
Orthologs

Proteins

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
Refseq ID NP_110392
Protein GI 13540527
UniProt ID Q9C0J1
mRNA ID NM_030765
Length 378
RefSeq Status REVIEWED
MLPPQPSAAHQGRGGRSGLLPKGPAMLCRLCWLVSYSLAVLLLGCLLFLRKAAKPAGDPTAHQPFWAPPTPRHSRCPPNHTVSSASLSLPSRHRLFLTYRHCRNFSILLEPSGCSKDTFLLLAIKSQPGHVERRAAIRSTWGRVGGWARGRQLKLVFLLGVAGSAPPAQLLAYESREFDDILQWDFTEDFFNLTLKELHLQRWVVAACPQAHFMLKGDDDVFVHVPNVLEFLDGWDPAQDLLVGDVIRQALPNRNTKVKYFIPPSMYRATHYPPYAGGGGYVMSRATVRRLQAIMEDAELFPIDDVFVGMCLRRLGLSPMHHAGFKTFGIRRPLDPLDPCLYRGLLLVHRLSPLEMWTMWALVTDEGLKCAAGPIPQR

Gene Information

Entrez Gene ID
Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
Gene Symbol
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000139 TAS:Reactome C Golgi membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0008378 IEA:InterPro F galactosyltransferase activity
GO:0016266 TAS:Reactome P O-glycan processing
GO:0005975 TAS:Reactome P carbohydrate metabolic process
GO:0044267 TAS:Reactome P cellular protein metabolic process
GO:0030203 TAS:Reactome P glycosaminoglycan metabolic process
GO:0018146 TAS:Reactome P keratan sulfate biosynthetic process
GO:0042339 TAS:Reactome P keratan sulfate metabolic process
GO:0043687 TAS:Reactome P post-translational protein modification
GO:0044281 TAS:Reactome P small molecule metabolic process

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_121315 Glycosaminoglycan metabolism
REACT_121120 Keratan sulfate biosynthesis
REACT_121288 Keratan sulfate/keratin metabolism
REACT_200727 O-linked glycosylation

Domain Information

InterPro Annotations

Accession Description
IPR002659 Glycosyl transferase, family 31

UniProt Annotations

Entry Information

Gene Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
Protein Entry
B3GN4_HUMAN
UniProt ID
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9C0J1-1; Sequence=Displayed; Name=2; IsoId=Q9C0J1-2; Sequence=VSP_025962;
Function Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides.
Pathway Protein modification; protein glycosylation.
Sequence Caution Sequence=AAL37219.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the glycosyltransferase 31 family.
Subcellular Location Golgi apparatus membrane ; Single-pass type II membrane protein .
Tissue Specificity Mainly expressed in brain tissues such as whole brain, hippocampus, amygdala, cerebellum and caudate nucleus. Also expressed in colon, esophagus and kidney.
Web Resource Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GNT4";

Identical and Related Proteins

Unique RefSeq proteins for LMP006645 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13540527 RefSeq NP_110392 378 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4

Identical Sequences to LMP006645 proteins

Reference Database Accession Length Protein Name
GI:13540527 GenBank ACP58704.1 378 Sequence 36 from patent US 7491797
GI:13540527 GenBank ACP88639.1 378 Sequence 36 from patent US 7504480
GI:13540527 GenBank ACW43159.1 378 Sequence 36 from patent US 7582293
GI:13540527 GenBank ACW64613.1 378 Sequence 36 from patent US 7589172
GI:13540527 GenBank ADS45528.1 378 Sequence 36 from patent US 7795412
GI:13540527 GenBank AEK14089.1 378 Sequence 4 from patent US 7972815

Related Sequences to LMP006645 proteins

Reference Database Accession Length Protein Name
GI:13540527 GenBank AAM17730.1 378 Sequence 2 from patent US 6361985
GI:13540527 GenBank AAH31399.1 378 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 [Homo sapiens]
GI:13540527 GenBank ABM82210.1 378 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 [synthetic construct]
GI:13540527 GenBank ABM85395.1 378 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4, partial [synthetic construct]
GI:13540527 RefSeq XP_001166798.1 378 PREDICTED: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 isoform X1 [Pan troglodytes]
GI:13540527 RefSeq XP_008955984.1 378 PREDICTED: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 [Pan paniscus]