Gene/Proteome Database (LMPD)

LMPD ID
LMP006653
Gene ID
85413
Species
Homo sapiens (Human)
Gene Name
solute carrier family 22 (organic cation/carnitine transporter), member 16
Gene Symbol
SLC22A16
Synonyms
CT2; FLIPT2; OAT6; OCT6; OKB1; dJ261K5.1
Alternate Names
solute carrier family 22 member 16; flipt 2; WUGSC:RG331P03.1; carnitine transporter 2; organic cation transporter 6; fly-like putative transporter 2; organic cation transporter OKB1; organic cation/carnitine transporter 6; fly-like putative organic ion transporter 2; solute carrier family 22 (organic cation transporter), member 16
Chromosome
6
Map Location
6q22.1|6q21-q22.1
Summary
This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. [provided by RefSeq, Dec 2011]
Orthologs
View orthologs and multiple alignments for SLC22A16

Proteins

solute carrier family 22 member 16
Refseq ID NP_149116
Protein GI 31542327
UniProt ID Q86VW1
mRNA ID NM_033125
Length 577
RefSeq Status VALIDATED
MGSRHFEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKLESENESKSSKLLLTTNNSGLEKTEAITPRDSGLGE

Gene Information

Entrez Gene ID
85413
Gene Name
solute carrier family 22 (organic cation/carnitine transporter), member 16
Gene Symbol
SLC22A16
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IDA:UniProtKB C integral component of membrane
GO:0005886 TAS:Reactome C plasma membrane
GO:0005275 IDA:MGI F amine transmembrane transporter activity
GO:0015226 IDA:UniProtKB F carnitine transmembrane transporter activity
GO:0015101 IDA:MGI F organic cation transmembrane transporter activity
GO:0046717 IDA:UniProtKB P acid secretion
GO:0015837 IDA:GOC P amine transport
GO:1902603 IDA:GOC P carnitine transmembrane transport
GO:0015879 IDA:UniProtKB P carnitine transport
GO:0030154 IEA:UniProtKB-KW P cell differentiation
GO:0007275 IEA:UniProtKB-KW P multicellular organismal development
GO:0015695 IDA:UniProtKB P organic cation transport
GO:0007338 IMP:UniProtKB P single fertilization
GO:0030317 IMP:UniProtKB P sperm motility
GO:0007283 IEA:UniProtKB-KW P spermatogenesis
GO:0055085 TAS:Reactome P transmembrane transport

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_22357 Organic cation transport
REACT_22345 Organic cation/anion/zwitterion transport
REACT_19118 SLC-mediated transmembrane transport
REACT_19305 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds

Domain Information

InterPro Annotations

Accession Description
IPR005828 General substrate transporter
IPR020846 Major facilitator superfamily domain

UniProt Annotations

Entry Information

Gene Name
solute carrier family 22 (organic cation/carnitine transporter), member 16
Protein Entry
S22AG_HUMAN
UniProt ID
Q86VW1
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q86VW1-1; Sequence=Displayed; Name=2; IsoId=Q86VW1-2; Sequence=VSP_031336, VSP_031337; Name=3; IsoId=Q86VW1-3; Sequence=VSP_031338;
Function High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent.
Sequence Caution Sequence=BAB71419.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Subcellular Location Membrane ; Multi-pass membrane protein . Cell membrane . Note=Detected in the plasma membrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis.
Tissue Specificity Widely expressed at low levels in adult tissues and fetal brain, lung, liver and kidney. Expressed in testis and epididymis (at protein level). Expressed at lower levels in bone marrow and fetal liver. Expressed in hematopoietic cells, including CD34(+) leukocytes and leukemia cells. Abundantly expressed in ovarian cancer clear-cell adenocarcinoma. Expressed in endometrium (at protein level); highly expressed during the normal secretory phase, but expression is significantly reduced in the proliferative phase. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP006653 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31542327 RefSeq NP_149116 577 solute carrier family 22 member 16

Identical Sequences to LMP006653 proteins

Reference Database Accession Length Protein Name
GI:31542327 GenBank ADC20505.1 577 Sequence 989 from patent US 7638288
GI:31542327 GenBank ADZ15999.1 577 solute carrier family 22 (organic cation/carnitine transporter), member 16, partial [synthetic construct]
GI:31542327 GenBank AED17703.1 577 Sequence 14 from patent US 7879563
GI:31542327 GenBank AGD01466.1 577 Sequence 989 from patent US 8338124
GI:31542327 GenBank AHD79643.1 577 Sequence 29287 from patent US 8586006
GI:31542327 GenBank AIC52670.1 577 SLC22A16, partial [synthetic construct]

Related Sequences to LMP006653 proteins

Reference Database Accession Length Protein Name
GI:31542327 GenBank AAK58593.1 577 organic cation transporter OKB1 [Homo sapiens]
GI:31542327 GenBank AAN52928.1 577 putative transmembrane transporter FLIPT 2 [Homo sapiens]
GI:31542327 GenBank ABW60520.1 577 Sequence 163 from patent US 7276593
GI:31542327 GenBank ADL99192.1 578 Sequence 2 from patent US 7723019
GI:31542327 RefSeq XP_518688.2 577 PREDICTED: solute carrier family 22 member 16 isoform X1 [Pan troglodytes]
GI:31542327 RefSeq XP_003255612.1 577 PREDICTED: solute carrier family 22 member 16 [Nomascus leucogenys]