Gene/Proteome Database (LMPD)

LMPD ID
LMP006656
Gene ID
375775
Species
Homo sapiens (Human)
Gene Name
patatin-like phospholipase domain containing 7
Gene Symbol
PNPLA7
Synonyms
C9orf111; NTE-R1; NTEL1
Alternate Names
patatin-like phospholipase domain-containing protein 7
Chromosome
9
Map Location
9q34.3
EC Number
3.1.1.-
Summary
Human patatin-like phospholipases, such as PNPLA7, have been implicated in regulation of adipocyte differentiation and have been induced by metabolic stimuli (Wilson et al., 2006 [PubMed 16799181]).[supplied by OMIM, Jun 2008]
Orthologs
View orthologs and multiple alignments for PNPLA7

Proteins

patatin-like phospholipase domain-containing protein 7 isoform a
Refseq ID NP_001092007
Protein GI 614458181
UniProt ID Q6ZV29
mRNA ID NM_001098537
Length 1342
RefSeq Status VALIDATED
MEEEKDDSPQADFCLGTALHSWGLWFTEEGSPSTMLTGIAVGALLALALVGVLILFMFRRLRQFRQAQPTPQYRFRKRDKVMFYGRKIMRKVTTLPNTLVENTALPRQRARKRTKVLSLAKRILRFKKEYPALQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHIVFVQLQEGEHVFQPREPDPSICVVQDGRLEVCIQDTDGTEVVVKEVLAGDSVHSLLSILDIITGHAAPYKTVSVRAAIPSTILRLPAAAFHGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNAESQAIPLVSVASVAAGKAKKQVFYGEEERLKKPPRLQESCDSDHGGGRPAAAGPLLKRSHSVPAPSIRKQILEELEKPGAGDPDPSAPQGGPGSATSDLGMACDRARVFLHSDEHPGSSVASKSRKSVMVAEIPSTVSQHSESHTDETLASRKSDAIFRAAKKDLLTLMKLEDSSLLDGRVALLHVPAGTVVSRQGDQDASILFVVSGLLHVYQRKIGSQEDTCLFLTRPGEMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYEIMRKQPTVVLGVAHTVVKRMSSFVRQIDFALDWVEVEAGRAIYRQGDKSDCTYIMLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVETLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGPVTGHQLGLPTEGSKWDLGNPAVNLSTVAVMPVSEEVPLTAFALELEHALSAIGPTLLLTSDNIKRRLGSAALDSVHEYRLSSWLGQQEDTHRIVLYQADGTLTPWTQRCVRQADCILIVGLGDQEPTVGELERMLESTAVRAQKQLILLHREEGPAPARTVEWLNMRSWCSGHLHLCCPRRVFSRRSLPKLVEMYKHVFQRPPDRHSDFSRLARVLTGNAIALVLGGGGARGCAQVGVLKALAECGIPVDMVGGTSIGAFVGALYSEERNYSQMRIRAKQWAEGMTSLMKAALDLTYPITSMFSGAGFNSSIFSVFKDQQIEDLWIPYFAITTDITASAMRVHTDGSLWWYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEVVKSSDYCEYLRPPIDSYSTLDFGKFNEICEVGYQHGRTVFDIWGRSGVLEKMLRDQQGPSKKPASAVLTCPNASFTDLAEIVSRIEPAKPAMVDDESDYQTEYEEELLDVPRDAYADFQSTSAQQGSDLEDESSLRHRHPSLAFPKLSEGSSDQDG
patatin-like phospholipase domain-containing protein 7 isoform b
Refseq ID NP_689499
Protein GI 614458145
UniProt ID Q6ZV29
mRNA ID NM_152286
Length 1317
RefSeq Status VALIDATED
MEEEKDDSPQLTGIAVGALLALALVGVLILFMFRRLRQFRQAQPTPQYRFRKRDKVMFYGRKIMRKVTTLPNTLVENTALPRQRARKRTKVLSLAKRILRFKKEYPALQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHIVFVQLQEGEHVFQPREPDPSICVVQDGRLEVCIQDTDGTEVVVKEVLAGDSVHSLLSILDIITGHAAPYKTVSVRAAIPSTILRLPAAAFHGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNAESQAIPLVSVASVAAGKAKKQVFYGEEERLKKPPRLQESCDSDHGGGRPAAAGPLLKRSHSVPAPSIRKQILEELEKPGAGDPDPSAPQGGPGSATSDLGMACDRARVFLHSDEHPGSSVASKSRKSVMVAEIPSTVSQHSESHTDETLASRKSDAIFRAAKKDLLTLMKLEDSSLLDGRVALLHVPAGTVVSRQGDQDASILFVVSGLLHVYQRKIGSQEDTCLFLTRPGEMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYEIMRKQPTVVLGVAHTVVKRMSSFVRQIDFALDWVEVEAGRAIYRQGDKSDCTYIMLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVETLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGPVTGHQLGLPTEGSKWDLGNPAVNLSTVAVMPVSEEVPLTAFALELEHALSAIGPTLLLTSDNIKRRLGSAALDSVHEYRLSSWLGQQEDTHRIVLYQADGTLTPWTQRCVRQADCILIVGLGDQEPTVGELERMLESTAVRAQKQLILLHREEGPAPARTVEWLNMRSWCSGHLHLCCPRRVFSRRSLPKLVEMYKHVFQRPPDRHSDFSRLARVLTGNAIALVLGGGGARGCAQVGVLKALAECGIPVDMVGGTSIGAFVGALYSEERNYSQMRIRAKQWAEGMTSLMKAALDLTYPITSMFSGAGFNSSIFSVFKDQQIEDLWIPYFAITTDITASAMRVHTDGSLWWYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEVVKSSDYCEYLRPPIDSYSTLDFGKFNEICEVGYQHGRTVFDIWGRSGVLEKMLRDQQGPSKKPASAVLTCPNASFTDLAEIVSRIEPAKPAMVDDESDYQTEYEEELLDVPRDAYADFQSTSAQQGSDLEDESSLRHRHPSLAFPKLSEGSSDQDG

Gene Information

Entrez Gene ID
375775
Gene Name
patatin-like phospholipase domain containing 7
Gene Symbol
PNPLA7
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005764 IEA:UniProtKB-KW C lysosome
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0004622 IEA:Ensembl F lysophospholipase activity
GO:0006629 IEA:InterPro P lipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00564 Glycerophospholipid metabolism
ko00564 Glycerophospholipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR000595 Cyclic nucleotide-binding domain
IPR018490 Cyclic nucleotide-binding-like
IPR002641 Patatin/Phospholipase A2-related
IPR014710 RmlC-like jelly roll fold

UniProt Annotations

Entry Information

Gene Name
patatin-like phospholipase domain containing 7
Protein Entry
PLPL7_HUMAN
UniProt ID
Q6ZV29
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q6ZV29-1; Sequence=Displayed; Name=2; IsoId=Q6ZV29-2; Sequence=VSP_026500, VSP_026501, VSP_026502; Note=No experimental confirmation available.; Name=3; IsoId=Q6ZV29-3; Sequence=VSP_026503; Note=No experimental confirmation available.; Name=4; IsoId=Q6ZV29-4; Sequence=VSP_026504, VSP_026505; Note=No experimental confirmation available.; Name=5; IsoId=Q6ZV29-5; Sequence=VSP_026500; Note=No experimental confirmation available.;
Function Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.
Sequence Caution Sequence=BAB71033.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=CAI14579.1; Type=Erroneous gene model prediction; Evidence= ;
Similarity Belongs to the NTE family.
Similarity Contains 1 patatin domain.
Similarity Contains 3 cyclic nucleotide-binding domains.
Subcellular Location Membrane ; Single-pass membrane protein {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP006656 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
614458181 RefSeq NP_001092007 1342 patatin-like phospholipase domain-containing protein 7 isoform a
614458145 RefSeq NP_689499 1317 patatin-like phospholipase domain-containing protein 7 isoform b

Identical Sequences to LMP006656 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP006656 proteins

Reference Database Accession Length Protein Name
GI:614458145 DBBJ BAC86036.1 1317 unnamed protein product [Homo sapiens]
GI:614458145 GenBank AAI67848.1 1342 Patatin-like phospholipase domain containing 7 [synthetic construct]
GI:614458181 GenBank AAI67848.1 1342 Patatin-like phospholipase domain containing 7 [synthetic construct]
GI:614458181 RefSeq XP_003817059.1 1342 PREDICTED: patatin-like phospholipase domain-containing protein 7 isoform X2 [Pan paniscus]
GI:614458145 RefSeq XP_006717165.1 1343 PREDICTED: patatin-like phospholipase domain-containing protein 7 isoform X8 [Homo sapiens]
GI:614458181 RefSeq XP_006717165.1 1343 PREDICTED: patatin-like phospholipase domain-containing protein 7 isoform X8 [Homo sapiens]
GI:614458181 RefSeq XP_006717166.1 1316 PREDICTED: patatin-like phospholipase domain-containing protein 7 isoform X9 [Homo sapiens]
GI:614458145 RefSeq XP_006717167.1 1309 PREDICTED: patatin-like phospholipase domain-containing protein 7 isoform X10 [Homo sapiens]
GI:614458145 RefSeq NP_001092007.2 1342 patatin-like phospholipase domain-containing protein 7 isoform a [Homo sapiens]
GI:614458181 RefSeq XP_008968394.1 1343 PREDICTED: patatin-like phospholipase domain-containing protein 7 isoform X1 [Pan paniscus]
GI:614458181 RefSeq XP_008968395.1 1343 PREDICTED: patatin-like phospholipase domain-containing protein 7 isoform X1 [Pan paniscus]
GI:614458145 SwissProt Q6ZV29.3 1317 RecName: Full=Patatin-like phospholipase domain-containing protein 7 [Homo sapiens]