Gene/Proteome Database (LMPD)

LMPD ID
LMP006657
Gene ID
Species
Homo sapiens (Human)
Gene Name
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
Gene Symbol
Synonyms
NET13; NSMASE-3; NSMASE3
Chromosome
2
Map Location
2q21.1
EC Number
3.1.4.12
Summary
Sphingomyelinases (EC 3.1.4.12), such as SMPD4, catalyze the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (Krut et al., 2006 [PubMed 16517606]).[supplied by OMIM, Mar 2008]
Orthologs

Proteins

sphingomyelin phosphodiesterase 4 isoform 1
Refseq ID NP_060221
Protein GI 102467484
UniProt ID Q9NXE4
mRNA ID NM_017751
Length 837
RefSeq Status VALIDATED
MTTFGAVAEWRLPSLRRATLWIPQWFAKKAIFNSPLEAAMAFPHLQQPSFLLASLKADSINKPFAQQCQDLVKVIEDFPAKELHTIFPWLVESIFGSLDGVLVGWNLRCLQGRVNPVEYSIVMEFLDPGGPMMKLVYKLQAEDYKFDFPVSYLPGPVKASIQECILPDSPLYHNKVQFTPTGGLGLNLALNPFEYYIFFFALSLITQKPLPVSLHVRTSDCAYFILVDRYLSWFLPTEGSVPPPLSSSPGGTSPSPPPRTPAIPFASYGLHHTSLLKRHISHQTSVNADPASHEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPHAKESFTPTEEHVLVVRLLLKHLHAFANSLKPEQASPSAHSHATSPLEEFKRAAVPRFVQQKLYLFLQHCFGHWPLDASFRAVLEMWLSYLQPWRYAPDKQAPGSDSQPRCVSEKWAPFVQENLLMYTKLFVGFLNRALRTDLVSPKHALMVFRVAKVFAQPNLAEMIQKGEQLFLEPELVIPHRQHRLFTAPTFTGSFLSPWPPAVTDASFKVKSHVYSLEGQDCKYTPMFGPEARTLVLRLAQLITQAKHTAKSISDQCAESPAGHSFLSWLGFSSMDTNGSYTANDLDEMGQDSVRKTDEYLEKALEYLRQIFRLSEAQLRQFTLALGTTQDENGKKQLPDCIVGEDGLILTPLGRYQIINGLRRFEIEYQGDPELQPIRSYEIASLVRTLFRLSSAINHRFAGQMAALCSRDDFLGSFCRYHLTEPGLASRHLLSPVGRRQVAGHTRGPRLSLRFLGSYRTLVSLLLAFFVASLFCVGPLPCTLLLTLGYVLYASAMTLLTERGKLHQP
sphingomyelin phosphodiesterase 4 isoform 2
Refseq ID NP_060421
Protein GI 102467481
UniProt ID B1PBA3
mRNA ID NM_017951
Length 866
RefSeq Status VALIDATED
MTTFGAVAEWRLPSLRRATLWIPQWFAKKAIFNSPLEAAMAFPHLQQPSFLLASLKADSINKPFAQQCQDLVKVIEDFPAKELHTIFPWLVESIFGSLDGVLVGWNLRCLQGRVNPVEYSIVMEFLDPGGPMMKLVYKLQAEDYKFDFPVSYLPGPVKASIQECILPDSPLYHNKVQFTPTGGLGLNLALNPFEYYIFFFALSLITQKPLPVSLHVRTSDCAYFILVDRYLSWFLPTEGSVPPPLSSSPGGTSPSPPPRTPAIPFASYGLHHTSLLKRHISHQTSVNADPASHEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPHAKLEVLHYRLSVSSALYSPAQPSLQALHAYQESFTPTEEHVLVVRLLLKHLHAFANSLKPEQASPSAHSHATSPLEEFKRAAVPRFVQQKLYLFLQHCFGHWPLDASFRAVLEMWLSYLQPWRYAPDKQAPGSDSQPRCVSEKWAPFVQENLLMYTKLFVGFLNRALRTDLVSPKHALMVFRVAKVFAQPNLAEMIQKGEQLFLEPELVIPHRQHRLFTAPTFTGSFLSPWPPAVTDASFKVKSHVYSLEGQDCKYTPMFGPEARTLVLRLAQLITQAKHTAKSISDQCAESPAGHSFLSWLGFSSMDTNGSYTANDLDEMGQDSVRKTDEYLEKALEYLRQIFRLSEAQLRQFTLALGTTQDENGKKQLPDCIVGEDGLILTPLGRYQIINGLRRFEIEYQGDPELQPIRSYEIASLVRTLFRLSSAINHRFAGQMAALCSRDDFLGSFCRYHLTEPGLASRHLLSPVGRRQVAGHTRGPRLSLRFLGSYRTLVSLLLAFFVASLFCVGPLPCTLLLTLGYVLYASAMTLLTERGKLHQP
sphingomyelin phosphodiesterase 4 isoform 3
Refseq ID NP_001164554
Protein GI 283806604
UniProt ID Q9NXE4
mRNA ID NM_001171083
Length 764
RefSeq Status VALIDATED
MTTFGAVAEWRLPSLRRATLWIPQWFAKKAIFNSPLEAAMAFPHLQQPSFLLASLKADSINKPFAQQCQDLVKVIEDFPAKGPVKASIQECILPDSPLYHNKVQFTPTGGLGLNLALNPFEYYIFFFALSLITQKPLPVSLHVRTSDCAYFILVDRYLSWFLPTEGSVPPPLSSSPGGTSPSPPPRTPAIPFASYGLHHTSLLKRHISHQTSVNADPASHEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPHAKESFTPTEEHVLVVRLLLKHLHAFANSLKPEQASPSAHSHATSPLEEFKRAAVPRFVQQKLYLFLQHCFGHWPLDASFRAVLEMWLSYLQPWRYAPDKQAPGSDSQPRCVSEKWAPFVQENLLMYTKLFVGFLNRALRTDLVSPKHALMVFRVAKVFAQPNLAEMIQKGEQLFLEPELVIPHRQHRLFTAPTFTGSFLSPWPPAVTDASFKVKSHVYSLEGQDCKYTPMFGPEARTLVLRLAQLITQAKHTAKSISDQCAESPAGHSFLSWLGFSSMDTNGSYTANDLDEMGQDSVRKTDEYLEKALEYLRQIFRLSEAQLRQFTLALGTTQDENGKKQLPDCIVGEDGLILTPLGRYQIINGLRRFEIEYQGDPELQPIRSYEIASLVRTLFRLSSAINHRFAGQMAALCSRDDFLGSFCRYHLTEPGLASRHLLSPVGRRQVAGHTRGPRLSLRFLGSYRTLVSLLLAFFVASLFCVGPLPCTLLLTLGYVLYASAMTLLTERGKLHQP

Gene Information

Entrez Gene ID
Gene Name
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
Gene Symbol
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IDA:HGNC C Golgi apparatus
GO:0005783 IDA:BHF-UCL C endoplasmic reticulum
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005802 IDA:HGNC C trans-Golgi network
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0050290 IDA:HGNC F sphingomyelin phosphodiesterase D activity
GO:0004767 TAS:Reactome F sphingomyelin phosphodiesterase activity
GO:0071356 IDA:BHF-UCL P cellular response to tumor necrosis factor
GO:0046513 IDA:BHF-UCL P ceramide biosynthetic process
GO:0046475 IDA:BHF-UCL P glycerophospholipid catabolic process
GO:0006687 TAS:Reactome P glycosphingolipid metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006665 TAS:Reactome P sphingolipid metabolic process
GO:0006685 IDA:HGNC P sphingomyelin catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa01100 Metabolic pathways
hsa00600 Sphingolipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3DJ-11281 sphingomyelin metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_116105 Glycosphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR024129 Sphingomyelin phosphodiesterase 4

UniProt Annotations

Entry Information

Gene Name
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
Protein Entry
NSMA3_HUMAN
UniProt ID
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=10; Name=1; IsoId=Q9NXE4-1; Sequence=Displayed; Name=2; IsoId=Q9NXE4-2; Sequence=VSP_022481; Name=3; IsoId=Q9NXE4-3; Sequence=VSP_022480; Note=No experimental confirmation available.; Name=4; IsoId=Q9NXE4-4; Sequence=VSP_022482; Note=No experimental confirmation available.; Name=5; IsoId=Q9NXE4-5; Sequence=VSP_022479, VSP_022483; Note=No experimental confirmation available.; Name=6; IsoId=Q9NXE4-6; Sequence=VSP_044494, VSP_044495, VSP_022481; Name=7; IsoId=Q9NXE4-7; Sequence=VSP_054382, VSP_054385; Note=No experimental confirmation available.; Name=8; IsoId=Q9NXE4-8; Sequence=VSP_044494, VSP_044495, VSP_054386, VSP_022481; Note=No experimental confirmation available.; Name=9; IsoId=Q9NXE4-9; Sequence=VSP_054383, VSP_054384; Note=No experimental confirmation available.; Name=10; IsoId=Q9NXE4-10; Sequence=VSP_055343, VSP_022481; Note=No experimental confirmation available.;
Biophysicochemical Properties pH dependence: Optimum pH is 7.0. ;
Catalytic Activity Sphingomyelin + H(2)O = N-acylsphingosine + phosphocholine.
Cofactor Name=Mg(2+); Xref=ChEBI
Enzyme Regulation Activated by phosphatidylserine and tumor necrosis factor (TNF). Inhibited by scyphostatin.
Function Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide.
Sequence Caution Sequence=BAA91368.1; Type=Erroneous initiation; Evidence= ; Sequence=BAA91567.1; Type=Erroneous initiation; Evidence= ; Sequence=BAA92656.1; Type=Erroneous initiation; Evidence= ;
Subcellular Location Endoplasmic reticulum membrane ; Single-pass membrane protein . Golgi apparatus membrane ; Single-pass membrane protein .
Tissue Specificity Widely expressed, with highest levels in heart and skeletal muscle.

Identical and Related Proteins

Unique RefSeq proteins for LMP006657 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
102467484 RefSeq NP_060221 837 sphingomyelin phosphodiesterase 4 isoform 1
102467481 RefSeq NP_060421 866 sphingomyelin phosphodiesterase 4 isoform 2
283806604 RefSeq NP_001164554 764 sphingomyelin phosphodiesterase 4 isoform 3

Identical Sequences to LMP006657 proteins

Reference Database Accession Length Protein Name
GI:102467481 GenBank ACA48221.1 866 SKNY protein [Homo sapiens]

Related Sequences to LMP006657 proteins

Reference Database Accession Length Protein Name
GI:102467481 DBBJ BAA92656.1 889 KIAA1418 protein, partial [Homo sapiens]
GI:283806604 DBBJ BAG61230.1 764 unnamed protein product [Homo sapiens]
GI:283806604 GenBank AAY14883.1 798 unknown [Homo sapiens]
GI:102467481 GenBank EAW55597.1 866 hypothetical protein FLJ20297, isoform CRA_a [Homo sapiens]
GI:102467484 GenBank EAW55601.1 837 hypothetical protein FLJ20297, isoform CRA_e [Homo sapiens]
GI:102467484 GenBank JAA07592.1 837 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) [Pan troglodytes]
GI:102467484 GenBank JAA19427.1 837 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) [Pan troglodytes]
GI:102467481 GenBank JAA32075.1 866 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) [Pan troglodytes]
GI:102467484 GenBank JAA32076.1 837 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) [Pan troglodytes]
GI:102467481 GenBank JAA32077.1 866 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) [Pan troglodytes]
GI:102467481 GenBank JAA42552.1 866 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) [Pan troglodytes]
GI:102467481 GenBank JAA42553.1 866 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) [Pan troglodytes]
GI:102467484 GenBank JAA42554.1 837 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) [Pan troglodytes]
GI:102467484 RefSeq NP_060421.2 866 sphingomyelin phosphodiesterase 4 isoform 2 [Homo sapiens]
GI:283806604 RefSeq XP_005334563.1 765 PREDICTED: sphingomyelin phosphodiesterase 4 isoform X3 [Ictidomys tridecemlineatus]
GI:283806604 RefSeq XP_005636668.1 765 PREDICTED: sphingomyelin phosphodiesterase 4 isoform X5 [Canis lupus familiaris]
GI:283806604 RefSeq XP_008067016.1 765 PREDICTED: sphingomyelin phosphodiesterase 4 isoform X3 [Tarsius syrichta]
GI:283806604 RefSeq XP_008997625.1 778 PREDICTED: sphingomyelin phosphodiesterase 4 [Callithrix jacchus]