Gene/Proteome Database (LMPD)

LMPD ID
LMP006660
Gene ID
81616
Species
Homo sapiens (Human)
Gene Name
acyl-CoA synthetase bubblegum family member 2
Gene Symbol
ACSBG2
Synonyms
BGR; BRGL; PRTD-NY3; PRTDNY3
Chromosome
19
Map Location
19p13.3
EC Number
6.2.1.3

Proteins

long-chain-fatty-acid--CoA ligase ACSBG2 isoform a
Refseq ID NP_001276107
Protein GI 574584557
UniProt ID Q5FVE4
mRNA ID NM_001289178
Length 666
RefSeq Status VALIDATED
MTGTPKTQEGAKDLEVDMNKTEVTPRLWTTCRDGEVLLRLSKHGPGHETPMTIPEFFRESVNRFGTYPALASKNGKKWEILNFNQYYEACRKAAKSLIKLGLERFHGVGILGFNSAEWFITAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKAIIQYRLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGVMLSHDNITWIAGAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGALTYFAQADALKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKKMLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAEFFLSLDIPIGELYGLSESSGPHTISNQNNYRLLSCGKILTGCKNMLFQQNKDGIGEICLWGRHIFMGYLESETETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIPVETLVKKKIPIISNAMLVGDKLKFLSMLLTLKCEMNQMSGEPLDKLNFEAINFCRGLGSQASTVTEIVKQQDPLVYKAIQQGINAVNQEAMNNAQRIEKWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQIDHMYH
long-chain-fatty-acid--CoA ligase ACSBG2 isoform a
Refseq ID NP_112186
Protein GI 83745141
UniProt ID Q5FVE4
mRNA ID NM_030924
Length 666
RefSeq Status VALIDATED
Protein sequence is identical to GI:574584557 (mRNA isoform)
long-chain-fatty-acid--CoA ligase ACSBG2 isoform a
Refseq ID NP_001276106
Protein GI 574584718
UniProt ID Q5FVE4
mRNA ID NM_001289177
Length 666
RefSeq Status VALIDATED
Protein sequence is identical to GI:574584557 (mRNA isoform)
long-chain-fatty-acid--CoA ligase ACSBG2 isoform b
Refseq ID NP_001276108
Protein GI 574584557
UniProt ID Q5FVE4
mRNA ID NM_001289179
Length 666
RefSeq Status VALIDATED
MTGTPKTQEGAKDLEVDMNKTEVTPRLWTTCRDGEVLLRLSKHGPGHETPMTIPEFFRESVNRFGTYPALASKNGKKWEILNFNQYYEACRKAAKSLIKLGLERFHGVGILGFNSAEWFITAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKAIIQYRLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGVMLSHDNITWIAGAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGALTYFAQADALKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKKMLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAEFFLSLDIPIGELYGLSESSGPHTISNQNNYRLLSCGKILTGCKNMLFQQNKDGIGEICLWGRHIFMGYLESETETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIPVETLVKKKIPIISNAMLVGDKLKFLSMLLTLKCEMNQMSGEPLDKLNFEAINFCRGLGSQASTVTEIVKQQDPLVYKAIQQGINAVNQEAMNNAQRIEKWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQIDHMYH
long-chain-fatty-acid--CoA ligase ACSBG2 isoform c
Refseq ID NP_001276109
Protein GI 574584557
UniProt ID Q5FVE4
mRNA ID NM_001289180
Length 666
RefSeq Status VALIDATED
MTGTPKTQEGAKDLEVDMNKTEVTPRLWTTCRDGEVLLRLSKHGPGHETPMTIPEFFRESVNRFGTYPALASKNGKKWEILNFNQYYEACRKAAKSLIKLGLERFHGVGILGFNSAEWFITAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKAIIQYRLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGVMLSHDNITWIAGAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGALTYFAQADALKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKKMLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAEFFLSLDIPIGELYGLSESSGPHTISNQNNYRLLSCGKILTGCKNMLFQQNKDGIGEICLWGRHIFMGYLESETETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIPVETLVKKKIPIISNAMLVGDKLKFLSMLLTLKCEMNQMSGEPLDKLNFEAINFCRGLGSQASTVTEIVKQQDPLVYKAIQQGINAVNQEAMNNAQRIEKWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQIDHMYH

Gene Information

Entrez Gene ID
81616
Gene Name
acyl-CoA synthetase bubblegum family member 2
Gene Symbol
ACSBG2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:HPA C cytoplasm
GO:0005829 IEA:Ensembl C cytosol
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0005739 IDA:MGI C mitochondrion
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0047617 IDA:MGI F acyl-CoA hydrolase activity
GO:0004467 IDA:MGI F long-chain fatty acid-CoA ligase activity
GO:0030154 IEA:UniProtKB-KW P cell differentiation
GO:0006631 IDA:MGI P fatty acid metabolic process
GO:0001676 IDA:GOC P long-chain fatty acid metabolic process
GO:0007275 IEA:UniProtKB-KW P multicellular organismal development
GO:0007283 IEA:UniProtKB-KW P spermatogenesis

KEGG Pathway Links

KEGG Pathway ID Description
hsa04920 Adipocytokine signaling pathway
hsa03320 PPAR signaling pathway

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY66-387 fatty acid alpha-oxidation II
PWY-5972 stearate biosynthesis I (animals)

Domain Information

InterPro Annotations

Accession Description
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
acyl-CoA synthetase bubblegum family member 2
Protein Entry
ACBG2_HUMAN
UniProt ID
Q5FVE4
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5FVE4-1; Sequence=Displayed; Name=2; IsoId=Q5FVE4-2; Sequence=VSP_030719; Note=No experimental confirmation available.; Name=3; IsoId=Q5FVE4-3; Sequence=VSP_030718; Note=No experimental confirmation available.; Name=4; IsoId=Q5FVE4-4; Sequence=VSP_030717; Note=No experimental confirmation available.;
Catalytic Activity ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. {ECO
Developmental Stage Weakly or not expressed in fetal testis. Highly expressed in adult testis and moderately in elderly testis.
Function Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis.
Sequence Caution Sequence=CAE12157.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
Similarity Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.
Subcellular Location Cytoplasm. Membrane; Peripheral membrane protein.
Tissue Specificity Testis-specific. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP006660 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
574584557 RefSeq NP_001276107 666 long-chain-fatty-acid--CoA ligase ACSBG2 isoform a
574584557 RefSeq NP_001276108 666 long-chain-fatty-acid--CoA ligase ACSBG2 isoform b
574584557 RefSeq NP_001276109 666 long-chain-fatty-acid--CoA ligase ACSBG2 isoform c

Identical Sequences to LMP006660 proteins

Reference Database Accession Length Protein Name
GI:574584557 DBBJ BAG52714.1 666 unnamed protein product [Homo sapiens]
GI:574584557 DBBJ BAG52714.1 666 unnamed protein product [Homo sapiens]
GI:574584557 DBBJ BAG52714.1 666 unnamed protein product [Homo sapiens]
GI:574584557 EMBL CBH19185.1 666 unnamed protein product [Homo sapiens]
GI:574584557 EMBL CBH19185.1 666 unnamed protein product [Homo sapiens]
GI:574584557 EMBL CBH19185.1 666 unnamed protein product [Homo sapiens]
GI:574584557 GenBank EAW69111.1 666 acyl-CoA synthetase bubblegum family member 2 [Homo sapiens]
GI:574584557 GenBank EAW69111.1 666 acyl-CoA synthetase bubblegum family member 2 [Homo sapiens]
GI:574584557 GenBank EAW69111.1 666 acyl-CoA synthetase bubblegum family member 2 [Homo sapiens]
GI:574584557 GenBank AHD78784.1 666 Sequence 28428 from patent US 8586006
GI:574584557 GenBank AHD78784.1 666 Sequence 28428 from patent US 8586006
GI:574584557 GenBank AHD78784.1 666 Sequence 28428 from patent US 8586006
GI:574584557 RefSeq NP_001276106.1 666 long-chain-fatty-acid--CoA ligase ACSBG2 isoform a [Homo sapiens]
GI:574584557 RefSeq NP_001276106.1 666 long-chain-fatty-acid--CoA ligase ACSBG2 isoform a [Homo sapiens]
GI:574584557 RefSeq NP_001276106.1 666 long-chain-fatty-acid--CoA ligase ACSBG2 isoform a [Homo sapiens]
GI:574584557 SwissProt Q5FVE4.2 666 RecName: Full=Long-chain-fatty-acid--CoA ligase ACSBG2; AltName: Full=Acyl-CoA synthetase bubblegum family member 2; AltName: Full=Bubblegum-related protein; AltName: Full=PRTD-NY3 [Homo sapiens]
GI:574584557 SwissProt Q5FVE4.2 666 RecName: Full=Long-chain-fatty-acid--CoA ligase ACSBG2; AltName: Full=Acyl-CoA synthetase bubblegum family member 2; AltName: Full=Bubblegum-related protein; AltName: Full=PRTD-NY3 [Homo sapiens]
GI:574584557 SwissProt Q5FVE4.2 666 RecName: Full=Long-chain-fatty-acid--CoA ligase ACSBG2; AltName: Full=Acyl-CoA synthetase bubblegum family member 2; AltName: Full=Bubblegum-related protein; AltName: Full=PRTD-NY3 [Homo sapiens]

Related Sequences to LMP006660 proteins

Reference Database Accession Length Protein Name
GI:574584557 EMBL CAB66788.1 666 hypothetical protein [Homo sapiens]
GI:574584557 EMBL CAB66788.1 666 hypothetical protein [Homo sapiens]
GI:574584557 EMBL CAB66788.1 666 hypothetical protein [Homo sapiens]
GI:574584557 EMBL CAE12156.1 666 bubblegum related protein [Homo sapiens]
GI:574584557 EMBL CAE12156.1 666 bubblegum related protein [Homo sapiens]
GI:574584557 EMBL CAE12156.1 666 bubblegum related protein [Homo sapiens]
GI:574584557 GenBank AAH90046.1 666 Acyl-CoA synthetase bubblegum family member 2 [Homo sapiens]
GI:574584557 GenBank AAH90046.1 666 Acyl-CoA synthetase bubblegum family member 2 [Homo sapiens]
GI:574584557 GenBank AAH90046.1 666 Acyl-CoA synthetase bubblegum family member 2 [Homo sapiens]
GI:574584557 GenBank ABM84914.1 666 acyl-CoA synthetase bubblegum family member 2, partial [synthetic construct]
GI:574584557 GenBank ABM84914.1 666 acyl-CoA synthetase bubblegum family member 2, partial [synthetic construct]
GI:574584557 GenBank ABM84914.1 666 acyl-CoA synthetase bubblegum family member 2, partial [synthetic construct]
GI:574584557 GenBank ACE86522.1 666 acyl-CoA synthetase bubblegum family member 2 protein, partial [synthetic construct]
GI:574584557 GenBank ACE86522.1 666 acyl-CoA synthetase bubblegum family member 2 protein, partial [synthetic construct]
GI:574584557 GenBank ACE86522.1 666 acyl-CoA synthetase bubblegum family member 2 protein, partial [synthetic construct]
GI:574584557 GenBank ACE87201.1 666 acyl-CoA synthetase bubblegum family member 2 protein [synthetic construct]
GI:574584557 GenBank ACE87201.1 666 acyl-CoA synthetase bubblegum family member 2 protein [synthetic construct]
GI:574584557 GenBank ACE87201.1 666 acyl-CoA synthetase bubblegum family member 2 protein [synthetic construct]