Gene/Proteome Database (LMPD)
LMPD ID
LMP006662
Gene ID
Species
Homo sapiens (Human)
Gene Name
phospholipase C, eta 1
Gene Symbol
Synonyms
PLCL3
Alternate Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1; PLC-L3; PLC eta 1; PLC-eta-1; phospholipase C-eta-1; phospholipase C-eta1a; phospholipase C-eta1b; phospholipase C-like 3; phospholipase C-like protein 3; phosphoinositide phospholipase C-eta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-1
Chromosome
3
Map Location
3q25.31
EC Number
3.1.4.11
Summary
PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 [PubMed 15702972]).[supplied by OMIM, Jun 2009]
Orthologs
Proteins
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform a | |
---|---|
Refseq ID | NP_001124432 |
Protein GI | 195972871 |
UniProt ID | Q4KWH8 |
mRNA ID | NM_001130960 |
Length | 1693 |
RefSeq Status | VALIDATED |
MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSSSENNSHYVRKRSIGDRILRRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRTTRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENSLAEDKDGRRKGKASIKDPHFLNFNKKLSSSSSALLHKDTSQGDTIVSTAHMSVTGEQLGMSSPRGGRTTSNATSNCQENPCPSKSLSPKQHLAPDPVVNPTQDLHGVKIKEKGNPEDFVEGKSILSGSVLSHSNLEIKNLEGNRGKGRAATSFSLSDVSMLCSDIPDLHSTAILQESVISHLIDNVTLTNENEPGSSISALIGQFDETNNQALTVVSHLHNTSVMSGHCPLPSLGLKMPIKHGFCKGKSKSSFLCSSPELIALSSSETTKHATNTVYETTCTPISKTKPDDDLSSKAKTAALESNLPGSPNTSRGWLPKSPTKGEDWETLKSCSPASSPDLTLEDVIADPTLCFNSGESSLVEIDGESENLSLTTCEYRREGTSQLASPLKLKYNQGVVEHFQRGLRNGYCKETLRPSVPEIFNNIQDVKTQSISYLAYQGAGFVHNHFSDSDAKMFQTCVPQQSSAQDMHVPVPKQLAHLPLPALKLPSPCKSKSLGDLTSEDIACNFESKYQCISKSFVTTGIRDKKGVTVKTKSLEPIDALTEQLRKLVSFDQEDNCQVLYSKQDANQLPRALVRKLSSRSQSRVRNIASRAKEKQEANKQKVPNPSNGAGVVLRNKPSAPTPAVNRHSTGSYIAGYLKNTKGGGLEGRGIPEGACTALHYGHVDQFCSDNSVLQTEPSSDDKPEIYFLLRL |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform b | |
---|---|
Refseq ID | NP_055811 |
Protein GI | 57863298 |
UniProt ID | Q4KWH8 |
mRNA ID | NM_014996 |
Length | 1655 |
RefSeq Status | VALIDATED |
MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEIYGKNRQLQGLKGLFNKNPRHSSSENNSHYVRKRSIGDRILRRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRTTRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENSLAEDKDGRRKGKASIKDPHFLNFNKKLSSSSSALLHKDTSQGDTIVSTAHMSVTGEQLGMSSPRGGRTTSNATSNCQENPCPSKSLSPKQHLAPDPVVNPTQDLHGVKIKEKGNPEDFVEGKSILSGSVLSHSNLEIKNLEGNRGKGRAATSFSLSDVSMLCSDIPDLHSTAILQESVISHLIDNVTLTNENEPGSSISALIGQFDETNNQALTVVSHLHNTSVMSGHCPLPSLGLKMPIKHGFCKGKSKSSFLCSSPELIALSSSETTKHATNTVYETTCTPISKTKPDDDLSSKAKTAALESNLPGSPNTSRGWLPKSPTKGEDWETLKSCSPASSPDLTLEDVIADPTLCFNSGESSLVEIDGESENLSLTTCEYRREGTSQLASPLKLKYNQGVVEHFQRGLRNGYCKETLRPSVPEIFNNIQDVKTQSISYLAYQGAGFVHNHFSDSDAKMFQTCVPQQSSAQDMHVPVPKQLAHLPLPALKLPSPCKSKSLGDLTSEDIACNFESKYQCISKSFVTTGIRDKKGVTVKTKSLEPIDALTEQLRKLVSFDQEDNCQVLYSKQDANQLPRALVRKLSSRSQSRVRNIASRAKEKQEANKQKVPNPSNGAGVVLRNKPSAPTPAVNRHSTGSYIAGYLKNTKGGGLEGRGIPEGACTALHYGHVDQFCSDNSVLQTEPSSDDKPEIYFLLRL |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform c | |
---|---|
Refseq ID | NP_001124433 |
Protein GI | 195972873 |
UniProt ID | Q4KWH8 |
mRNA ID | NM_001130961 |
Length | 1002 |
RefSeq Status | VALIDATED |
MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSSSENNSHYVRKRSIGDRILRRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRTTRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENSLVQI |
Gene Information
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0005737 | IDA:MGI | C | cytoplasm |
GO:0005829 | IEA:Ensembl | C | cytosol |
GO:0005886 | TAS:Reactome | C | plasma membrane |
GO:0005509 | IEA:InterPro | F | calcium ion binding |
GO:0050429 | IDA:MGI | F | calcium-dependent phospholipase C activity |
GO:0004435 | IEA:UniProtKB-EC | F | phosphatidylinositol phospholipase C activity |
GO:0004871 | IEA:UniProtKB-KW | F | signal transducer activity |
GO:0043647 | TAS:Reactome | P | inositol phosphate metabolic process |
GO:0016042 | IEA:UniProtKB-KW | P | lipid catabolic process |
GO:0048015 | IDA:MGI | P | phosphatidylinositol-mediated signaling |
GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
BIOCYC Pathway Links
BIOCYC Pathway ID | Description |
---|---|
PWY-6351 | D-myo-inositol (1,4,5)-trisphosphate biosynthesis |
PWY-6367 | D-myo-inositol-5-phosphate metabolism |
REACTOME Pathway Links
REACTOME Pathway ID | Description |
---|---|
REACT_150154 | Inositol phosphate metabolism |
REACT_150312 | Synthesis of IP3 and IP4 in the cytosol |
Domain Information
InterPro Annotations
Accession | Description |
---|---|
IPR028392 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 |
IPR000008 | C2 domain |
IPR018247 | EF-Hand 1, calcium-binding site |
IPR002048 | EF-hand domain |
IPR011992 | EF-hand domain pair |
IPR017946 | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain |
IPR001192 | Phosphoinositide phospholipase C family |
IPR000909 | Phospholipase C, phosphatidylinositol-specific , X domain |
IPR001711 | Phospholipase C, phosphatidylinositol-specific, Y domain |
IPR015359 | Phospholipase C, phosphoinositol-specific, EF-hand-like |
IPR001849 | Pleckstrin homology domain |
IPR011993 | Pleckstrin homology-like domain |
UniProt Annotations
Entry Information
Comments
Comment Type | Description |
---|---|
Alternative Products | Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=PLC-eta-1; IsoId=Q4KWH8-1; Sequence=Displayed; Name=2; IsoId=Q4KWH8-2; Sequence=VSP_032901, VSP_032902; Note=No experimental confirmation available.; Name=3; Synonyms=PLC-eta-1a; IsoId=Q4KWH8-3; Sequence=VSP_032904, VSP_032905; Name=4; IsoId=Q4KWH8-4; Sequence=VSP_032902, VSP_032903, VSP_032906; Note=No experimental confirmation available.; |
Catalytic Activity | 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. |
Cofactor | Name=Ca(2+); Xref=ChEBI |
Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. |
Sequence Caution | Sequence=BAB14129.1; Type=Erroneous initiation; Evidence= ; |
Similarity | Contains 1 C2 domain. {ECO |
Similarity | Contains 1 PH domain. {ECO |
Similarity | Contains 1 PI-PLC X-box domain. {ECO |
Similarity | Contains 1 PI-PLC Y-box domain. {ECO |
Similarity | Contains 2 EF-hand domains. {ECO |
Subcellular Location | Cytoplasm . Membrane . |
Tissue Specificity | Expressed in brain and to a lower extent in lung. In brain, it is found in cerebrum, cerebellum and spinal cord. |
Identical and Related Proteins
Unique RefSeq proteins for LMP006662 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
195972871 | RefSeq | NP_001124432 | 1693 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform a |
57863298 | RefSeq | NP_055811 | 1655 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform b |
195972873 | RefSeq | NP_001124433 | 1002 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform c |
Identical Sequences to LMP006662 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:195972873 | GenBank | AAW22607.1 | 1002 | phospholipase C-eta1a [Homo sapiens] |
GI:195972871 | GenBank | AAW22608.1 | 1693 | phospholipase C-eta1b [Homo sapiens] |
GI:57863298 | GenBank | AAI13951.1 | 1655 | Phospholipase C, eta 1 [Homo sapiens] |
GI:195972873 | GenBank | AED62140.1 | 1002 | Sequence 22 from patent US 7902154 |
GI:195972871 | GenBank | AED62141.1 | 1693 | Sequence 23 from patent US 7902154 |
GI:57863298 | GenBank | AHE03263.1 | 1655 | Sequence 63351 from patent US 8586006 |
GI:195972871 | SwissProt | Q4KWH8.1 | 1693 | RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1; AltName: Full=Phosphoinositide phospholipase C-eta-1; AltName: Full=Phospholipase C-eta-1; Short=PLC-eta-1; AltName: Full=Phospholipase C-like protein 3; Short=PLC-L3 [Homo sapiens] |
Related Sequences to LMP006662 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:195972873 | GenBank | AAW22608.1 | 1693 | phospholipase C-eta1b [Homo sapiens] |
GI:57863298 | GenBank | AAW22608.1 | 1693 | phospholipase C-eta1b [Homo sapiens] |
GI:57863298 | GenBank | AED62141.1 | 1693 | Sequence 23 from patent US 7902154 |
GI:195972873 | GenBank | AED62141.1 | 1693 | Sequence 23 from patent US 7902154 |
GI:195972871 | RefSeq | XP_001149022.1 | 1693 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5 [Pan troglodytes] |
GI:195972873 | RefSeq | NP_001124432.1 | 1693 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform a [Homo sapiens] |
GI:57863298 | RefSeq | NP_001124432.1 | 1693 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform a [Homo sapiens] |
GI:195972873 | RefSeq | XP_003310105.1 | 1002 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X8 [Pan troglodytes] |
GI:195972871 | RefSeq | XP_003806142.1 | 1693 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X2 [Pan paniscus] |
GI:195972873 | RefSeq | XP_003806143.1 | 1002 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X6 [Pan paniscus] |
GI:195972871 | RefSeq | XP_005247295.1 | 1705 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1 [Homo sapiens] |
GI:195972871 | RefSeq | XP_005247296.1 | 1673 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X2 [Homo sapiens] |
GI:57863298 | RefSeq | XP_005247296.1 | 1673 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X2 [Homo sapiens] |
GI:57863298 | RefSeq | XP_006713604.1 | 1685 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X3 [Homo sapiens] |
GI:195972871 | RefSeq | XP_008976691.1 | 1683 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X4 [Pan paniscus] |
GI:195972871 | RefSeq | XP_009444989.1 | 1683 | PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1 [Pan troglodytes] |
GI:57863298 | SwissProt | Q4KWH8.1 | 1693 | RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1; AltName: Full=Phosphoinositide phospholipase C-eta-1; AltName: Full=Phospholipase C-eta-1; Short=PLC-eta-1; AltName: Full=Phospholipase C-like protein 3; Short=PLC-L3 [Homo sapiens] |
GI:195972873 | SwissProt | Q4KWH8.1 | 1693 | RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1; AltName: Full=Phosphoinositide phospholipase C-eta-1; AltName: Full=Phospholipase C-eta-1; Short=PLC-eta-1; AltName: Full=Phospholipase C-like protein 3; Short=PLC-L3 [Homo sapiens] |