Gene/Proteome Database (LMPD)

LMPD ID
LMP006667
Gene ID
55862
Species
Homo sapiens (Human)
Gene Name
ethylmalonyl-CoA decarboxylase 1
Gene Symbol
ECHDC1
Synonyms
HEL-S-76; MMCD; dJ351K20.2
Alternate Names
ethylmalonyl-CoA decarboxylase; methylmalonyl-CoA decarboxylase; epididymis secretory protein Li 76; enoyl CoA hydratase domain containing 1; enoyl Coenzyme A hydratase domain containing 1; enoyl-CoA hydratase domain-containing protein 1
Chromosome
6
Map Location
6q22.33
EC Number
4.1.1.94

Proteins

ethylmalonyl-CoA decarboxylase isoform 1
Refseq ID NP_001002030
Protein GI 157694516
UniProt ID Q9NTX5
mRNA ID NM_001002030
Length 301
RefSeq Status VALIDATED
MAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFIQGPPEVIRALKKSVCSGRELYLEEALQNERDLLGTVWGGPANLEAIAKKGKFNK
ethylmalonyl-CoA decarboxylase isoform 2
Refseq ID NP_060949
Protein GI 50593027
UniProt ID Q9NTX5
mRNA ID NM_018479
Length 145
RefSeq Status VALIDATED
MAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPETSFNKCCAGSRLGIGWRSRIYYSM
ethylmalonyl-CoA decarboxylase isoform 3
Refseq ID NP_001099014
Protein GI 157694520
UniProt ID Q9NTX5
mRNA ID NM_001105544
Length 226
RefSeq Status VALIDATED
MMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFIQGPPEVIRALKKSVCSGRELYLEEALQNERDLLGTVWGGPANLEAIAKKGKFNK
ethylmalonyl-CoA decarboxylase isoform 4
Refseq ID NP_001099015
Protein GI 157694522
UniProt ID Q9NTX5
mRNA ID NM_001105545
Length 70
RefSeq Status VALIDATED
MMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPETSFNKCCAGSRLGIGWRSRIYYSM
ethylmalonyl-CoA decarboxylase isoform 5
Refseq ID NP_001132982
Protein GI 213417737
UniProt ID Q9NTX5
mRNA ID NM_001139510
Length 307
RefSeq Status VALIDATED
MALKQEMAKSLLKTASLSGRTKLLHQTGLSLYSTSHGFYEEEVKKTLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMFMQNTLTRFMRLPLISVALVQGWALGGGAEFTTACDFRLMTPESKIRFVHKEMGIIPSWGGTTRLVEIIGSRQALKVLSGALKLDSKNALNIGMVEEVLQSSDETKSLEEAQEWLKQFIQGPPEVIRALKKSVCSGRELYLEEALQNERDLLGTVWGGPANLEAIAKKGKFNK

Gene Information

Entrez Gene ID
55862
Gene Name
ethylmalonyl-CoA decarboxylase 1
Gene Symbol
ECHDC1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 ISS:UniProtKB C cytosol
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0016831 ISS:UniProtKB F carboxy-lyase activity
GO:0004492 IEA:UniProtKB-EC F methylmalonyl-CoA decarboxylase activity

KEGG Pathway Links

KEGG Pathway ID Description
hsa00640 Propanoate metabolism
ko00640 Propanoate metabolism

Domain Information

InterPro Annotations

Accession Description
IPR029045 ClpP/crotonase-like domain
IPR001753 Crotonase_core_superfam
IPR018376 Enoyl-CoA hydratase/isomerase, conserved site

UniProt Annotations

Entry Information

Gene Name
ethylmalonyl-CoA decarboxylase 1
Protein Entry
ECHD1_HUMAN
UniProt ID
Q9NTX5
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q9NTX5-1; Sequence=Displayed; Name=2; IsoId=Q9NTX5-2; Sequence=VSP_022498; Name=3; IsoId=Q9NTX5-3; Sequence=VSP_042581; Note=No experimental confirmation available.; Name=4; Synonyms=HEL-S-76; IsoId=Q9NTX5-4; Sequence=VSP_042581, VSP_042583; Name=5; IsoId=Q9NTX5-5; Sequence=VSP_022498, VSP_042583; Note=No experimental confirmation available.; Name=6; IsoId=Q9NTX5-6; Sequence=VSP_022498, VSP_042582; Note=No experimental confirmation available.;
Catalytic Activity (S)-ethylmalonyl-CoA = butanoyl-CoA + CO(2).
Catalytic Activity (S)-methylmalonyl-CoA = propanoyl-CoA + CO(2).
Function Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level.
Sequence Caution Sequence=AAF67657.1; Type=Frameshift; Positions=121, 123, 125; Evidence= ; Sequence=CAI20295.1; Type=Erroneous gene model prediction; Evidence= ; Sequence=CAI20297.1; Type=Erroneous gene model prediction; Evidence= ;
Similarity Belongs to the enoyl-CoA hydratase/isomerase family.
Subcellular Location Cytoplasm, cytosol .

Identical and Related Proteins

Unique RefSeq proteins for LMP006667 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
157694516 RefSeq NP_001002030 301 ethylmalonyl-CoA decarboxylase isoform 1
50593027 RefSeq NP_060949 145 ethylmalonyl-CoA decarboxylase isoform 2
157694520 RefSeq NP_001099014 226 ethylmalonyl-CoA decarboxylase isoform 3
157694522 RefSeq NP_001099015 70 ethylmalonyl-CoA decarboxylase isoform 4
213417737 RefSeq NP_001132982 307 ethylmalonyl-CoA decarboxylase isoform 5

Identical Sequences to LMP006667 proteins

Reference Database Accession Length Protein Name
GI:50593027 EMBL CAD35123.1 145 unnamed protein product [Homo sapiens]
GI:157694516 GenBank EAW48107.1 301 enoyl Coenzyme A hydratase domain containing 1, isoform CRA_g [Homo sapiens]
GI:213417737 GenBank EAW48108.1 307 enoyl Coenzyme A hydratase domain containing 1, isoform CRA_h [Homo sapiens]
GI:157694516 GenBank ACE86706.1 301 enoyl Coenzyme A hydratase domain containing 1 protein, partial [synthetic construct]
GI:157694516 GenBank ACE87391.1 301 enoyl Coenzyme A hydratase domain containing 1 protein [synthetic construct]
GI:157694522 GenBank ACF94508.1 70 epididymis secretory protein Li 76 [Homo sapiens]
GI:50593027 GenBank AHD71373.1 145 Sequence 6067 from patent US 8586006
GI:157694516 GenBank AIC51859.1 301 ECHDC1, partial [synthetic construct]
GI:157694520 RefSeq XP_004044706.1 226 PREDICTED: ethylmalonyl-CoA decarboxylase [Gorilla gorilla gorilla]
GI:157694522 RefSeq XP_004044708.1 70 PREDICTED: ethylmalonyl-CoA decarboxylase [Gorilla gorilla gorilla]
GI:157694520 RefSeq XP_004087693.1 226 PREDICTED: ethylmalonyl-CoA decarboxylase isoform 4 [Nomascus leucogenys]
GI:157694522 RefSeq XP_004087694.1 70 PREDICTED: ethylmalonyl-CoA decarboxylase isoform 5 [Nomascus leucogenys]
GI:157694516 RefSeq XP_005267104.1 301 PREDICTED: ethylmalonyl-CoA decarboxylase isoform X1 [Homo sapiens]
GI:157694516 RefSeq XP_005267105.1 301 PREDICTED: ethylmalonyl-CoA decarboxylase isoform X2 [Homo sapiens]
GI:50593027 RefSeq XP_005267107.1 145 PREDICTED: ethylmalonyl-CoA decarboxylase isoform X4 [Homo sapiens]
GI:157694520 RefSeq XP_009240497.1 226 PREDICTED: ethylmalonyl-CoA decarboxylase isoform X2 [Pongo abelii]
GI:157694520 RefSeq XP_009450030.1 226 PREDICTED: ethylmalonyl-CoA decarboxylase isoform X2 [Pan troglodytes]
GI:157694522 RefSeq XP_009450034.1 70 PREDICTED: ethylmalonyl-CoA decarboxylase isoform X5 [Pan troglodytes]
GI:213417737 SwissProt Q9NTX5.2 307 RecName: Full=Ethylmalonyl-CoA decarboxylase; AltName: Full=Enoyl-CoA hydratase domain-containing protein 1; AltName: Full=Methylmalonyl-CoA decarboxylase; Short=MMCD [Homo sapiens]

Related Sequences to LMP006667 proteins

Reference Database Accession Length Protein Name
GI:157694522 EMBL CAD35123.1 145 unnamed protein product [Homo sapiens]
GI:213417737 EMBL CAD39128.1 301 hypothetical protein [Homo sapiens]
GI:157694520 EMBL CAD39128.1 301 hypothetical protein [Homo sapiens]
GI:157694520 GenBank EAW48107.1 301 enoyl Coenzyme A hydratase domain containing 1, isoform CRA_g [Homo sapiens]
GI:157694516 GenBank EAW48108.1 307 enoyl Coenzyme A hydratase domain containing 1, isoform CRA_h [Homo sapiens]
GI:157694520 GenBank ACE86706.1 301 enoyl Coenzyme A hydratase domain containing 1 protein, partial [synthetic construct]
GI:157694520 GenBank ACE87391.1 301 enoyl Coenzyme A hydratase domain containing 1 protein [synthetic construct]
GI:157694522 GenBank AHD71373.1 145 Sequence 6067 from patent US 8586006
GI:213417737 GenBank AIC51859.1 301 ECHDC1, partial [synthetic construct]
GI:157694520 GenBank AIC51859.1 301 ECHDC1, partial [synthetic construct]
GI:157694522 RefSeq NP_060949.2 145 ethylmalonyl-CoA decarboxylase isoform 2 [Homo sapiens]
GI:213417737 RefSeq NP_001002030.1 301 ethylmalonyl-CoA decarboxylase isoform 1 [Homo sapiens]
GI:157694520 RefSeq NP_001002030.1 301 ethylmalonyl-CoA decarboxylase isoform 1 [Homo sapiens]
GI:157694516 RefSeq NP_001132982.1 307 ethylmalonyl-CoA decarboxylase isoform 5 [Homo sapiens]
GI:213417737 RefSeq XP_003255733.1 307 PREDICTED: ethylmalonyl-CoA decarboxylase isoform 2 [Nomascus leucogenys]
GI:213417737 RefSeq NP_001092043.2 307 ethylmalonyl-CoA decarboxylase [Pan troglodytes]
GI:213417737 RefSeq XP_003827679.1 307 PREDICTED: ethylmalonyl-CoA decarboxylase isoform X1 [Pan paniscus]
GI:157694522 RefSeq XP_004087692.1 145 PREDICTED: ethylmalonyl-CoA decarboxylase isoform 3 [Nomascus leucogenys]
GI:50593027 RefSeq XP_005267106.1 151 PREDICTED: ethylmalonyl-CoA decarboxylase isoform X3 [Homo sapiens]
GI:157694522 RefSeq XP_005267106.1 151 PREDICTED: ethylmalonyl-CoA decarboxylase isoform X3 [Homo sapiens]
GI:157694522 RefSeq XP_005267107.1 145 PREDICTED: ethylmalonyl-CoA decarboxylase isoform X4 [Homo sapiens]
GI:50593027 RefSeq XP_008951216.1 151 PREDICTED: ethylmalonyl-CoA decarboxylase isoform X3 [Pan paniscus]
GI:50593027 RefSeq XP_008951217.1 145 PREDICTED: ethylmalonyl-CoA decarboxylase isoform X4 [Pan paniscus]
GI:50593027 RefSeq XP_008951218.1 145 PREDICTED: ethylmalonyl-CoA decarboxylase isoform X4 [Pan paniscus]
GI:157694516 RefSeq XP_009450027.1 301 PREDICTED: ethylmalonyl-CoA decarboxylase isoform X1 [Pan troglodytes]
GI:157694516 RefSeq XP_009450028.1 301 PREDICTED: ethylmalonyl-CoA decarboxylase isoform X1 [Pan troglodytes]
GI:157694516 RefSeq XP_009450029.1 301 PREDICTED: ethylmalonyl-CoA decarboxylase isoform X1 [Pan troglodytes]
GI:50593027 RefSeq XP_009450031.1 151 PREDICTED: ethylmalonyl-CoA decarboxylase isoform X3 [Pan troglodytes]
GI:50593027 RefSeq XP_009450033.1 145 PREDICTED: ethylmalonyl-CoA decarboxylase isoform X4 [Pan troglodytes]
GI:157694516 SwissProt Q9NTX5.2 307 RecName: Full=Ethylmalonyl-CoA decarboxylase; AltName: Full=Enoyl-CoA hydratase domain-containing protein 1; AltName: Full=Methylmalonyl-CoA decarboxylase; Short=MMCD [Homo sapiens]