Gene/Proteome Database (LMPD)

LMPD ID
LMP006669
Gene ID
23646
Species
Homo sapiens (Human)
Gene Name
phospholipase D family, member 3
Gene Symbol
PLD3
Synonyms
AD19; HU-K4; HUK4
Alternate Names
phospholipase D3; hindIII K4L homolog; choline phosphatase 3; phosphatidylcholine-hydrolyzing phospholipase D3
Chromosome
19
Map Location
19q13.2
EC Number
3.1.4.4
Summary
This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014]
Orthologs
View orthologs and multiple alignments for PLD3

Proteins

phospholipase D3
Refseq ID NP_036400
Protein GI 166197683
UniProt ID Q8IV08
mRNA ID NM_012268
Length 490
RefSeq Status REVIEWED
MKPKLMYQELKVPAEEPANELPMNEIEAWKAAEKKARWVLLVLILAVVGFGALMTQLFLWEYGDLHLFGPNQRPAPCYDPCEAVLVESIPEGLDFPNASTGNPSTSQAWLGLLAGAHSSLDIASFYWTLTNNDTHTQEPSAQQGEEVLRQLQTLAPKGVNVRIAVSKPSGPQPQADLQALLQSGAQVRMVDMQKLTHGVLHTKFWVVDQTHFYLGSANMDWRSLTQVKELGVVMYNCSCLARDLTKIFEAYWFLGQAGSSIPSTWPRFYDTRYNQETPMEICLNGTPALAYLASAPPPLCPSGRTPDLKALLNVVDNARSFIYVAVMNYLPTLEFSHPHRFWPAIDDGLRRATYERGVKVRLLISCWGHSEPSMRAFLLSLAALRDNHTHSDIQVKLFVVPADEAQARIPYARVNHNKYMVTERATYIGTSNWSGNYFTETAGTSLLVTQNGRGGLRSQLEAIFLRDWDSPYSHDLDTSADSVGNACRLL
phospholipase D3
Refseq ID NP_001278240
Protein GI 605052028
UniProt ID Q8IV08
mRNA ID NM_001291311
Length 490
RefSeq Status REVIEWED
Protein sequence is identical to GI:166197683 (mRNA isoform)
phospholipase D3
Refseq ID NP_001026866
Protein GI 72534684
UniProt ID Q8IV08
mRNA ID NM_001031696
Length 490
RefSeq Status REVIEWED
Protein sequence is identical to GI:166197683 (mRNA isoform)

Gene Information

Entrez Gene ID
23646
Gene Name
phospholipase D family, member 3
Gene Symbol
PLD3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0070290 IEA:UniProtKB-EC F N-acylphosphatidylethanolamine-specific phospholipase D activity
GO:0004630 TAS:ProtInc F phospholipase D activity
GO:0008219 IEA:UniProtKB-KW P cell death
GO:0046474 TAS:Reactome P glycerophospholipid biosynthetic process
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0006655 TAS:Reactome P phosphatidylglycerol biosynthetic process
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00565 Ether lipid metabolism
hsa00564 Glycerophospholipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_160158 Role of phospholipids in phagocytosis
REACT_121280 Synthesis of PG

Domain Information

InterPro Annotations

Accession Description
IPR001736 Phospholipase D/Transphosphatidylase

UniProt Annotations

Entry Information

Gene Name
phospholipase D family, member 3
Protein Entry
PLD3_HUMAN
UniProt ID
Q8IV08
Species
Human

Comments

Comment Type Description
Catalytic Activity A phosphatidylcholine + H(2)O = choline + a phosphatidate.
Disease Alzheimer disease 19 (AD19) [MIM
Function Probably involved in APP processing.
Interaction P19838:NFKB1; NbExp=2; IntAct=EBI-2689908, EBI-300010;
Ptm Glycosylated. {ECO
Sequence Caution Sequence=AAB16799.1; Type=Frameshift; Positions=52; Evidence= ;
Similarity Belongs to the phospholipase D family.
Similarity Contains 2 PLD phosphodiesterase domains.
Subcellular Location Endoplasmic reticulum membrane ; Single-pass type II membrane protein .
Subunit Interacts with APP.
Tissue Specificity Widely expressed. In the brain, high levels of expression are detected in the frontal, temporal and occipital cortices and hippocampus. Expressed at low level in corpus callosum. {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP006669 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
166197683 RefSeq NP_036400 490 phospholipase D3

Identical Sequences to LMP006669 proteins

Reference Database Accession Length Protein Name
GI:166197683 GenBank AIC51012.1 490 PLD3, partial [synthetic construct]
GI:166197683 RefSeq XP_006723184.1 490 PREDICTED: phospholipase D3 isoform X8 [Homo sapiens]
GI:166197683 RefSeq XP_006723185.1 490 PREDICTED: phospholipase D3 isoform X9 [Homo sapiens]
GI:166197683 RefSeq XP_006723186.1 490 PREDICTED: phospholipase D3 isoform X10 [Homo sapiens]
GI:166197683 RefSeq XP_006723187.1 490 PREDICTED: phospholipase D3 isoform X11 [Homo sapiens]
GI:166197683 RefSeq NP_001278240.1 490 phospholipase D3 [Homo sapiens]

Related Sequences to LMP006669 proteins

Reference Database Accession Length Protein Name
GI:166197683 RefSeq XP_009230868.1 490 PREDICTED: phospholipase D3 isoform X1 [Pongo abelii]
GI:166197683 RefSeq XP_009230869.1 490 PREDICTED: phospholipase D3 isoform X1 [Pongo abelii]
GI:166197683 RefSeq XP_009230870.1 490 PREDICTED: phospholipase D3 isoform X1 [Pongo abelii]
GI:166197683 RefSeq XP_009230872.1 490 PREDICTED: phospholipase D3 isoform X1 [Pongo abelii]
GI:166197683 RefSeq XP_009230873.1 490 PREDICTED: phospholipase D3 isoform X1 [Pongo abelii]
GI:166197683 RefSeq XP_009230874.1 490 PREDICTED: phospholipase D3 isoform X1 [Pongo abelii]